Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-05-2013 | Retinal Disorders

Retinal thickness in eyes with idiopathic macular hole after vitrectomy with internal limiting membrane peeling

Authors: Kouichi Ohta, Atsuko Sato, Emi Fukui

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2013

Abstract

Purpose

To compare the thickness of each retinal layer in the parafoveal and perifoveal regions of eyes after successful closure of a macular hole (MH) by pars plana vitrectomy with internal limiting membrane (ILM) peeling to the corresponding areas of the normal fellow eyes.

Methods

Twenty-two eyes of 22 patients with an idiopathic MH who underwent PPV with ILM peeling at the Matsumoto Dental University Hospital were studied. The retinal thickness was measured manually with the volume scan mode of the Spectralis HRA + OCT (Heidelberg Engineering, Germany).

Results

The average postoperative parafoveal thickness of the temporal sector was 314.8 μm, and that of the corresponding area of the fellow eyes was 325.0 μm (P = 0.01). The parafoveal thickness of the nasal sector was 360.7 μm, and that of the fellow eyes was 339.6 μm (P < 0.0001). Changes in the inner retinal layer thicknesses contributed to the decreased temporal and increased nasal sectors. The perifoveal retinal thickness was significantly increased in all sectors after PPV, probably due to an increase in the outer nuclear layer thickness.

Conclusions

PPV with ILM peeling for MHs can cause microstructural changes in wide areas of the macula region, suggesting a loss of longitudinal support of the Müller cells.

Kelly NE, Wendel RT (1991) Vitreous surgery for idiopathic macular holes: results of a pilot study. Arch Ophthalmol 109(5):654–659PubMedCrossRef

Wendel RT, Patel AC, Kelly NE, Salzano TC, Wells JW, Novack GD (1993) Vitreous surgery for macular holes. Ophthalmology 100(11):1671–1676PubMed

Olsen TW, Sternberg P Jr, Capone A Jr, Martin DF, Lim JI, Grossniklaus HE, Aaberg TM Sr (1998) Macular hole surgery using thorombin-activated fibrinogen and selective removal of the internal limiting memebrane. Retina 18(4):322–329PubMedCrossRef

Park DW, Sipperley JO, Sneed SR, Dugel PU, Jacobsen J (1999) Macular hole surgery with internal-limiting membrane peeling and intravitreous air. Ophthalmology 106(7):1392–1397PubMedCrossRef

Mester V, Kuhn F (2000) Internal limiting membrane removal in the management of full-thickness macular holes. Am J Ophthalmol 129(6):769–777PubMedCrossRef

Brooks HL Jr (2000) Macular hole surgery with and without internal limiting membrane peeling. Ophthalmology 107(10):1939–1948PubMedCrossRef

Tadayoni R, Paques M, Massin P, Mouki-Benani S, Mikol J, Gaudric A (2001) Dissociated optic nerve fiber layer appearance of the fundus after idiopathic epiretinal membrane removal. Ophthalmology 108(12):2279–2283PubMedCrossRef

Ito Y, Terasaki H, Takahashi A, Yamakoshi T, Kondo M, Nakamura M (2005) Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular holes. Ophthalmology 112(8):1415–1420PubMedCrossRef

Mitamura Y, Ohtsuka K (2005) Relationship of dissociated optic nerve fiber layer appearance to internal limiting membrane peeling. Ophthalmology 112(10):1766–1770PubMedCrossRef

10.

Ohta K, Sato A, Fukui E (2010) Asymmetrical thickness of parafoveal retina around surgically closed macular hole. Br J Ophthalmol 94(11):1545–1546PubMedCrossRef

11.

Sakamoto T, Miyazaki M, Hisatomi T, Nakamura T, Ueno A, Itaya K, Ishibashi T (2002) Triamcinolone-assisted pars plana vitrectomy improves the surgical procedures and decreases the post operative blood–ocular barrier breakdown. Graefes Arch Clin Exp Ophthalmol 240(6):423–429PubMedCrossRef

12.

Early Treatment Diabetic Retinopathy Study Research Group (1985) Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report No.1. Arch Ophthalmol 103(12):1796–1806CrossRef

13.

Grover S, Murthy RK, Brar VS, Chalam KV (2009) Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (Spectralis). Am J Ophthalmol 148(2):266–271PubMedCrossRef

14.

Ohta K, Sato A, Fukui E (2012) Comparison of parafoveal retinal thickness in eyes with idiopathic macular hole to that with rhegmatogenous retinal detachment after vitrectomy. J Clinic Experiment Ophthalmol 3:1. doi:10.4172/2155-9570.1000209

15.

Gass JDM (1999) Müller cell cone, an overlooked part of the anatomy of the fovea centralis. Arch Ophthalmol 117(6):821–823PubMedCrossRef

16.

Yamada E (1969) Some structural features of the fovea centralis in the human retina. Arch Ophthalmol 82(2):151–159PubMedCrossRef

17.

Wolf S, Schnurbusch U, Wiedemann P, Grosche J, Reichenbach A, Wolburg H (2004) Peeling of the basal membrane in the human retina. Ophthalmology 111:238–242PubMedCrossRef

18.

Inoue M, Arakawa A, Yamane S, Watanabe Y, Kadonosono K (2012) Long-term outcome of macular structure assessed by optical coherence tomography in eyes with spontaneous resolution of macular hole. Am J Ophthalmol 153(4):687–691PubMedCrossRef

19.

Matsumoto C, ArimuraE OS, Takada S, Hashimoto S, Shimomura Y (2003) Quantification of metamorphopsia in patients with epiretinal membranes. Invest Ophthalmol Vis Sci 44(9):4012–4016PubMedCrossRef

20.

Kinoshita T, Imaizumi H, Okushiba U, Miyamoto H, Ogino T, Mitamura Y (2012) Time course of changes in metamorphopsia, visual acuity, and OCT parameters after successful epiretinal membrane surgery. Invest Ophthalmol Vis Sci 53(7):3592–3597PubMedCrossRef

21.

Kuroyanagi K, Gunji H, Kato H, Gekka T, Arai K, Ito Y, Anzai K, Nishimoto F, Tsuneoka H (2010) Use of M-charts® in the evaluation of metamorphopsia after surgical removal of epiretinal membrane [in Japanese]. Jpn J Clin Ophthalmol 64(9):1551–1554

22.

Menke MN, Dabov S, Knecht P, Sturm V (2009) Reproducibility of retinal thickness measurements in healthy subjects using Spectralis optical coherence tomography. Am J Ophthalmol 147(3):467–472PubMedCrossRef

23.

Kumagai K, Hangai M, Larson E, Ogino N (2011) Vitreoretinal interface and foveal deformation in asymptomatic fellow eyes of patients with unilateral macular holes. Ophthalmology 118(8):1638–1644PubMedCrossRef

Title: Retinal thickness in eyes with idiopathic macular hole after vitrectomy with internal limiting membrane peeling
Authors: Kouichi Ohta
Atsuko Sato
Emi Fukui
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-012-2173-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Retinal thickness in eyes with idiopathic macular hole after vitrectomy with internal limiting membrane peeling

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 5/2013

Longitudinal change of refraction over at least 5 years in 15,000 patients

Influence of sutureless 23-gauge sclerotomy architecture on postoperative intraocular pressure decrease: results of a multivariate analysis

Gas tamponade for myopic foveoschisis with foveal detachment

Intraocular collision tumour: case report and literature review

Refractive lenticule extraction (ReLEx flex) and wavefront-optimized Femto-LASIK: comparison of contrast sensitivity and high-order aberrations at 1 year

Autoimmune retinopathy associated with colonic adenoma