Published in:
01-07-2011 | Case Report
Use of intravitreal triamcinolone and bevacizumab in Coats' disease with central macular edema
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2011
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Background
Intravitreal application of triamcinolone and bevacizumab in Coats' disease with macular edema to improve visual outcome.
Methods
Testing of best-corrected visual acuity (BCVA), ophthalmoscopy, optical coherence tomography, fluorescein angiography, 30° perimetry, and full-field electroretinography were performed at initial and follow-up visits. Medical treatment consisted of intravitreal injection of 1.25 mg bevazicumab and 1.25 mg triamcinolone, followed by intravitreal injections of 1.25 mg bevazicumab at weeks 4 and 10. Follow-up was 87 weeks.
Results
Perimetric results, including a temporal absolute scotoma and reduced electroretinographic amplitudes (photopic and scotopic conditions), did not significantly change during the follow-up, but foveal retinal thickness decreased from 505 μm to 212 μm, and BCVA increased from 0.3 at baseline to 1.25 and remained stable during subsequent follow-up.
Conclusions
Combined intravitreal treatment with bevacizumab and triamcinolone resulted in significant decrease of central retinal thickness and improved visual acuity in this case report. Severe local or systemic side-effects were not observed.