Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-06-2009 | Oculoplastics and Orbit

Botulinum toxin A injection for primary and recurrent chalazia

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2009

Abstract

Background

To study the efficacy and safety of subcutaneous botulinum toxin A injections in the treatment of primary and recurrent chalazia.

Methods

Prospective, placebo-controlled consecutive case-series trial. Sixty three patients were divided into two groups: group 1 consisting of 32 patients previously diagnosed with and treated for primary or recurrent chalazia with 2–5 international units (IU) in 0.2–0.5 ml of preserved saline solution of botulinum toxin injection, and group 2 consisting of 31 patients receiving placebo. The main outcome measures were localization and duration of the disease, size of chalazion before and after treatment, clinical resolution of chalazion, time to resolution, and complications of treatment.

Results

There was a clinically and statistically significant between-group difference in the rate of therapeutic success and post-therapeutic chalazion regression, but not in the rate of complications.

Conclusions

Botulinum toxin A injection is effective and safe treatment for primary and recurrent chalazia. Lesion regression that did not respond to the average of two injections would benefit more from surgical excision or systemic antibiotic therapy.

Dhaliwal U, Arora VK, Singh N, Bhatia A (2004) Cytopathology of chalazia. Diagn Cytopathol 31(2):118–122. doi:10.1002/dc.20092 PubMedCrossRef

Lempert SL, Jenkins MS, Brown SI (1979) Chalazia and rosacea. Arch Ophthalmol 97(9):1652–1653 SepPubMed

Dua HS, Nilawar DV (1982) Nonsurgical therapy of chalazion. Am J Ophthalmol 94:424–425PubMed

Perry HD, Serniuk RA (1980) Conservative treatment of chalazia. Ophthalmology 87:18–21

Pizzarello LD, Jakobiec FA, Hofeldt AJ et al (1978) Intralesional corticosteroid therapy of chalazia. Am J Ophthalmol 85:818PubMed

Watson AP, Austin DJ (1984) Treatment of chalazion with injection of a steroid suspension. Br J Ophthalmol 68:833. doi:10.1136/bjo.68.11.833 PubMedCrossRef

Ben Simon GJ, Huang L, Nakra T et al (2005) Intralesional triamcinolone acetonide injection for primary and recurrent chalazia: is it really effective? Ophthalmology 112:913–917. doi:10.1016/j.ophtha.2004.11.037 PubMedCrossRef

Epstein GA, Putterman AM (1988) Combined excision and drainage with intralesional corticosteroid injection in the treatment of chronic chalazia. Arch Ophthalmol 106:514–516PubMed

Chung CF, Lai JS, Li PS et al (2006) Subcutaneous extralesional triamcinolone acetonide injection versus conservative management in the treatment of chalazion. Hong Kong Med J 12(4):278–281PubMed

10.

Dutton JJ, Fowler AM (2007) Botulinum toxin in ophthalmology. Surv Ophthalmol 52(1):13–31. doi:10.1016/j.survophthal.2006.10.003 PubMedCrossRef

11.

Turton K, Chaddock JA, Acharya KR et al (2002) Botulinum and tetanus neurotoxin structure, function and therapeutic utility. Trends Biochem Sci 27:552–558. doi:10.1016/S0968–0004(02)02177–1 PubMedCrossRef

12.

Glogau RG (2002) Review of botulinum toxin for hyperhidrosis and cosmetic purposes. Clin J Pain 18:191–197. doi:10.1097/00002508–200211001–00012 CrossRef

13.

Kinkelin I, Hind M, Naumann M et al (2000) Effective treatment of frontal hyperhidrosis with botulinum toxin A. Br J Dermatol 143:824–827. doi:10.1046/j.1365–2133.2000.03839.x PubMedCrossRef

14.

Perra MT, Serra A, Sirigu P, Turno F (1996) Histochemical demonstration of acetyl cholinesterase activity in human meibomian gland. Eur J Histochem 40(19):39–44PubMed

15.

Aisa J, Lahoz M, Serrano P, Pérez-Castejón MC, Junquera C, Martinez-Ciriano MC, Pes N, Vera-Gil A (2001) Acetylcholinesterase-positive and paraformaldehyde-induced-fluorescence-positive innervation in the upper eyelid of the sheep (Ovis aries). Histol Histopathol 16(2):487–496PubMed

16.

Chung CW, Tigges M, Stone RA (1996) Peptidergic innervation of the primate meibomian gland. Invest Ophthalmol Vis Sci 37(1):238–245PubMed

17.

Prasad S, Gupta AK (1992) Subconjunctival total excision in the treatment of the chronic chalazia. Indian J Ophthalmol 40:103–106PubMed

18.

Thomas EL, Laborde RP (1986) Retinal and choroidal vascular occlusion following intralesional corticosteroid injection of chalazion. Ophthalmology 93:405–407PubMed

19.

Procope JA, Kidwell ED Jr (1996) Delayed postoperative hemorrhage complicating chalazion surgery. J Natl Med Assoc 86:865–866

Title: Botulinum toxin A injection for primary and recurrent chalazia
Publication date: 01-06-2009
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2009
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0992-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Botulinum toxin A injection for primary and recurrent chalazia

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 6/2009

Lack of association of VEGF (−2578 C → A) and ANG 2 (−35 G → C) gene polymorphisms with the progression of retinopathy of prematurity

Distance doubling visual acuity test: A reliable test for nonorganic visual loss

Human normal tear proteome

G.O.H Naumann, LM Holbach, F.E. Kruse: Applied Pathology for Ophthalmic Microsurgeons

Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation

Polylactide-glycoli acid and rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes