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Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 12/2008

01-12-2008 | Case Report

Rapid regression of retinal hemorrhage and neovascularization in a case of familial exudative vitreoretinopathy treated with intravitreal bevacizumab

Authors: Mizuki Tagami, Sentaro Kusuhara, Shigeru Honda, Yasutomo Tsukahara, Akira Negi

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2008

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Abstract

Purpose

To report a case of familial exudative vitreoretinopathy (FEVR) rapidly resolved by intravitreal injection of bevacizumab.

Methods

A 36-year-old woman complained about floaters and visual field defect. Funduscopic examinations revealed retinal vessel anastomosis located between the equator and ora serrata in both eyes. The right eye was accompanied with slight vitreous hemorrhage. Since the patient declined retinal cryopexy for cosmetic reasons, intravitreal bevacizumab injections (1.25 mg/0.05 ml) were performed in both eyes.

Results

Treatment resulted in the rapid regression and the accelerated fibrosis of neovascular tissues. At 4-month follow-up in the right eye and 1-month follow-up in the left, no signs of systemic or ocular complications were detected.

Conclusions

Intravitreal injection of bevacizumab may be considered as an alternative method in treating FEVR.
Literature
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go back to reference Criswick VG, Schepens CL (1969) Familial exudative vitreoretinopathy. Am J Ophthalmol 68:578–594PubMed Criswick VG, Schepens CL (1969) Familial exudative vitreoretinopathy. Am J Ophthalmol 68:578–594PubMed
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go back to reference van Nouhuys CE (1989) Juvenile retinal detachment as a complicaton of familial exudative vitreoretinopathy. Fortschr Ophthalmol 86:221–223PubMed van Nouhuys CE (1989) Juvenile retinal detachment as a complicaton of familial exudative vitreoretinopathy. Fortschr Ophthalmol 86:221–223PubMed
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7.
go back to reference Honda S, Hirabayashi H, Tsukahara Y et al (2008) Acute contraction of the proliferative membrane after an intravitreal injection of bevacizumab for advanced retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 246(7):1061–1063, doi:10.1007/s00417-008-0786-7 PubMedCrossRef Honda S, Hirabayashi H, Tsukahara Y et al (2008) Acute contraction of the proliferative membrane after an intravitreal injection of bevacizumab for advanced retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 246(7):1061–1063, doi:10.​1007/​s00417-008-0786-7 PubMedCrossRef
Metadata
Title
Rapid regression of retinal hemorrhage and neovascularization in a case of familial exudative vitreoretinopathy treated with intravitreal bevacizumab
Authors
Mizuki Tagami
Sentaro Kusuhara
Shigeru Honda
Yasutomo Tsukahara
Akira Negi
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-008-0949-6

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