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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2009 | Retinal Disorders

Evolution of lamellar macular hole studied by optical coherence tomography

Authors: P. G. Theodossiadis, V. G. Grigoropoulos, I. Emfietzoglou, P. Nikolaidis, I. Vergados, M. Apostolopoulos, G. P. Theodossiadis

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2009

Abstract

Purpose

To study the natural course of lamellar macular hole (LMH) as examined by optical coherence tomography (OCT) in a noncomparative observational case series.

Methods

Forty-one eyes of 41 patients with LMH were included in this analysis. Baseline and final OCT findings related to LMH diameter, foveal thickness and visual acuity (VA) were collected and compared. Mean follow-up was 37.1 months. Main outcome measures were best-corrected visual acuity (BCVA), diameter of the LMH opening, foveal thickness, epiretinal membrane (ERM), posterior vitreous detachment (PVD) and vitreoretinal traction.

Results

The diameter of the LMH increased by an average of 13.7%. A statistically significant association was found between the LMH diameter increase and the presence of ERM. The mean foveal thickness depicted a statistically significant decrease between the initial and the final examination. The decrease of the foveal thickness showed to correlate with visual acuity deterioration. BCVA was stable in 30 (78%) and deteriorated in 11 (22%) cases. In eight of the 11 cases, the visual acuity deterioration ranged from 2 to 15 letters.

Conclusion

We identified an increase of LMH diameter related to the presence of ERM and a decrease of the foveal thickness within a period of observation which ranged from 24 to 54 months (mean 37.1 months).

Gaudric A, Haouchine B, Massin P, Paques M, Blain P, Erginay A (1999) Macular hole formation: new data provided by optical coherence tomography. Arch Ophthalmol 117:744–751PubMed

Takahashi H, Kishi S (2000) Tomographic features of a lamellar macular hole formation and a lamellar hole that progressed to a full-thickness macular hole. Am J Ophthalmol 130:677–679, doi:10.1016/S0002-9394(00)00626-7 PubMedCrossRef

Haouchine B, Massin P, Gaudric A (2001) Foveal pseudocyst as the first step in macular hole formation: a prospective study by optical coherence tomography. Ophthalmology 108:15–22, doi:10.1016/S0161-6420(00)00519-4 PubMedCrossRef

Gass JD (1976) Lamellar macular hole: a complication of cystoid macular edema after cataract extraction. Arch Ophthalmol 94:793–800PubMed

Tanner V, Chauhan DS, Jackson TL, Williamson TH (2001) Optical coherence tomography of the vitreoretinal interface in macular hole formation. Br J Ophthalmol 85:1092–1097, doi:10.1136/bjo.85.9.1092 PubMedCrossRef

Uchino E, Uemura A, Ohba N (2001) Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol 119:1475–1479PubMed

Haouchine B, Massin P, Tadayoni R, Erginay A, Gaudric A (2004) Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography. Am J Ophthalmol 138:732–739, doi:10.1016/j.ajo.2004.06.088 PubMedCrossRef

Ko TH, Fujimoto JG, Duker JS, Paunescu LA, Drexler W, Baumal CR et al (2004) Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. Ophthalmology 111:2033–2043, doi:10.1016/j.ophtha.2004.05.021 PubMedCrossRef

Witkin AJ, Ko TH, Fujimoto JG, Schuman JS, Baumal CR, Rogers AH et al (2006) Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study. Ophthalmology 113:388–397, doi:10.1016/j.ophtha.2005.10.047 PubMedCrossRef

10.

Garretson BR, Pollack JS, Ruby AJ, Drenser KA, Williams GA, Sarrafizadeh R (2008) Vitrectomy for a symptomatic lamellar macular hole. Ophthalmology 115:884–886 [Epub 11 Dec 2007]PubMedCrossRef

11.

Wilkins JR, Puliafito CA, Hee MR, Duker JS, Reichel E, Coker JG et al (1996) Characterization of epiretinal membranes using optical coherence tomography. Ophthalmology 103:2142–2151PubMed

12.

Allen AW Jr, Gass JD (1976) Contraction of a perifoveal epiretinal membrane simulating a macular hole. Am J Ophthalmol 82:684–691PubMed

13.

Massin P, Vicaut E, Haouchine B et al (2001) Reproducibility of retinal mapping using optical coherence tomography. Arch Ophthalmol 119:1135–1142PubMed

14.

Polito A, Del Borrello M, Isola M et al (2005) Repeatability and reproducibility of fast macular thickness mapping with stratus optical coherence tomography. Arch Ophthalmol 123:1330–1337, doi:10.1001/archopht.123.10.1330 PubMedCrossRef

15.

Margherio RR, Margherio AR, Williams GA, Chow DR, Banach MJ (2000) Effect of perifoveal tissue dissection in the management of acute idiopathic full-thickness macular holes. Arch Ophthalmol 118:495–498PubMed

16.

Yooh HS, Brooks HL Jr, Capone A Jr, L’Hernault NL, Grossniklaus HE (1996) Ultrastructural features of tissue removed during idiopathic macular hole surgery. Am J Ophthalmol 122:67–75PubMed

17.

Mester V, Kuhn F (2000) Internal limiting membrane removal in the management of full-thickness macular holes. Am J Ophthalmol 129:769–777, doi:10.1016/S0002-9394(00)00358-5 PubMedCrossRef

18.

Blain P, Paques M, Massin P, Erginay A, Spielmann AC, Santiago PY et al (1998) Epiretinal membranes surrounding idiopathic macular holes. Retina 18:316–321PubMed

19.

Hikichi T, Akiba J, Trempe CL (1993) Effect of the vitreous on the prognosis of full-thickness idiopathic macular hole. Am J Ophthalmol 116:273–278PubMed

20.

Ullrich S, Haritoglou C, Gass C, Schaumberger M, Ulbig MW, Kampik A (2002) Macular hole size as a prognostic factor in macular hole surgery. Br J Ophthalmol 86:390–393, doi:10.1136/bjo.86.4.390 PubMedCrossRef

21.

Hirakawa M, Uemura A, Nakano T, Sakamoto T (2005) Pars plana vitrectomy with gas tamponade for lamellar macular holes. Am J Ophthalmol 140:1154–1155, doi:10.1016/j.ajo.2005.07.022 PubMedCrossRef

22.

Kokame GT, Tokuhara KG (2007) Surgical management of inner lamellar macular hole. Ophthalmic Surg Lasers Imaging 38:61–63PubMed

Title: Evolution of lamellar macular hole studied by optical coherence tomography
Authors: P. G. Theodossiadis
V. G. Grigoropoulos
I. Emfietzoglou
P. Nikolaidis
I. Vergados
M. Apostolopoulos
G. P. Theodossiadis
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2009
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0927-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Evolution of lamellar macular hole studied by optical coherence tomography

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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