Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-04-2008 | Cornea

Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study

Authors: Haitao Zhang, Liang Xu, Changxi Chen, Jost B. Jonas

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2008

Abstract

Background

To evaluate the distribution of central corneal thickness and its associations in the adult Chinese population.

Methods

The Beijing Eye Study 2006 is a population-based study including 3,251 (73.3%) subjects (aged 45+ years) out of 4,439 subjects who participated in the survey in 2001 and who returned for re-examination. Central corneal thickness (CCT) measurements were performed by slit lamp-based optical coherence tomography.

Results

Central corneal thickness measurement data were available for 3,100 (95.4%) subjects. Mean CCT was 556.2±33.1 μm (median: 553 μm; range: 429–688 μm). In multiple regression analysis, CCT was significantly associated with optic disc area (P = 0.043), urban region (P < 0.001; odds ratio (OR): 4.77; 95% confidence interval (CI): 2.37, 7.17), male gender (P < 0.001; OR: 5.64; 95%CI: 2.57, 8.71), and intraocular pressure measurements (P < 0.001). It was not significantly associated with body weight (P = 0.54) and body height (P = 0.66), age (P = 0.17), and refractive error (P = 0.43). Intraocular pressure (measured by pneumotonometry) increased for each μm central corneal thickness increase by 0.03 mmHg.

Conclusions

In the adult Chinese population, CCT was significantly associated optic disc area, urban region, and male gender. Intraocular pneumotonometric pressure measurements increased for each μm increase in central corneal thickness by 0.03 mmHg. CCT was not associated with age and refractive error.

Goldmann H, Schmidt T (1957) Über Applanationstonometrie. Ophthalmologica 134:221–242PubMedCrossRef

Ehlers N, Bramsen T, Sperling S (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol 53:34–43

Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parish RK 2nd, Wilson MR, Kass MA (2002) The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120:714–720PubMed

Herndon LW, Weizer JS, Stinnett SS (2004) Central corneal thickness as a risk factor for advanced glaucoma damage. Arch Ophthalmol 122:17–21PubMedCrossRef

Copt RP, Thomas R, Mermoud A (1999) Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma. Arch Ophthalmol 117:14–16PubMed

Xu L, Li J, Cui T, Hu A, Fan G, Zhang R, Yang H, Sun B, Jonas JB (2005) Refractive error in urban and rural adult Chinese in Beijing. Ophthalmology 112:1676–1683PubMedCrossRef

Wang Y, Xu L, Jonas JB (2006) Prevalence and causes of visual field loss as determined by frequency doubling perimetry in urban and rural adult Chinese. Am J Ophthalmol 141:1078–1086PubMedCrossRef

Wang Y, Xu L, Zhang L, Yang H, Ma Y, Jonas JB (2006) Optic disc size in a population-based study in Northern China. The Beijing Eye Study. Br J Ophthalmol 90:353–356PubMedCrossRef

Xu L, Wang Y, Wang S, Wang Y, Jonas JB (2007) High myopia and glaucoma susceptibility. The Beijing Eye Study. Ophthalmology 114:216–220PubMedCrossRef

10.

Littmann H (1982) Zur Bestimmung der wahren Größe eines Objektes auf dem Hintergrund des lebenden Auges. Klin Monatsbl Augenheilkd 180:286–289PubMed

11.

Wang Y, Xu L, Zhang L, Yang H, Ma Y, Jonas JB (2006) Optic disc size in a population-based study in Northern China. The Beijing Eye Study. Br J Ophthalmol 90:353–356PubMedCrossRef

12.

Cheung SW, Cho P, Douthwaite W (2000) Corneal shape of Hong Kong-Chinese. Ophthalmic Physiol Opt 20:119–125PubMedCrossRef

13.

Wolfs RC, Klaver CC, Vingerling JR, Grobbee DE, Hofman A, de Jong PT (1997) Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study. Am J Ophthalmol 123:767–772PubMed

14.

Su DH, Wong TY, Wong WL, Saw SM, Tan DT, Shen SY, Loon SC, Foster PJ, Aung T (2007) Singapore Malay Eye Study Group. Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology 2007 (in press) Corrected Proof, Available online 26 October 2007

15.

Tomidokoro A, Araie M, Iwase A (2007) Tajimi Study Group. Corneal thickness and relating factors in a population-based study in Japan: the Tajimi study. Am J Ophthalmol 144:152–154PubMedCrossRef

16.

Eysteinsson T, Jonasson F, Sasaki H, Arnarsson A, Sverrisson T, Sasaki K, Stefánsson E (2002) Reykjavik Eye Study Group. Central corneal thickness, radius of the corneal curvature and intraocular pressure in normal subjects using non-contact techniques: Reykjavik Eye Study. Acts Ophthalmol 80:11–15CrossRef

17.

Fam HB, How AC, Baskaran M, Lim KL, Chan YH, Aung T (2006) Central corneal thickness and its relationship to myopia in Chinese adults. Br J Ophthalmol 90:1451–1453PubMedCrossRef

18.

Hansen FK, Ehlers N (1971) Elevated tonometer readings caused by a thick cornea. Acta Ophthalmol 49:775–778CrossRef

19.

Ehlers N, Hansen FK (1974) Central corneal thickness in low-tension glaucoma. Acta Ophthalmol (Copenh) 52:740–746CrossRef

20.

Argus WA (1995) Ocular hypertension and central corneal thickness. Ophthalmology 102:1810–1812PubMed

21.

Herndon LW, Choudhri SA, Cox T, Damji KE, Shields MB, Alingham RR (1997) Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes. Arch Ophthalmol 115:1137–1141PubMed

22.

Stodtmeister R (1998) Applanation tonometry and correction according to corneal thickness. Acta Ophthalmol Scand 76:319–324PubMedCrossRef

23.

Shah S, Chatterjee A, Mathai M, Kelly SP, Kwartz J, Henson D, McLeod D (1999) Relationship between corneal thickness and measured intraocular pressure in a general ophthalmology clinic. Ophthalmology 106:2154–2160PubMedCrossRef

24.

Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44:367–408PubMedCrossRef

25.

Velten IM, Bergua A, Horn FK, Junemann A, Korth M (2000) Zentrale Hornhautdicke bei Normalen, Patienten mit okularer Hypertension, Normaldruck- und Offenwinkelglaukomen-eine klinische Studie. [Central corneal thickness in normal eyes, patients with ocular hypertension, normal-tension and open-angle glaucomas-a clinical study]. Klin Monatsbl Augenheilkd 217:219–224PubMedCrossRef

26.

Jonas JB, Königsreuther KA (1994) Macrodiscs in eyes with flat and large corneas. Ger J Ophthalmol 3:179–181PubMed

27.

Jonas JB, Kling F, Gründler AE (1997) Optic disc shape, corneal astigmatism and amblyopia. Ophthalmology 104:1934–1937PubMed

28.

Pakravan M, Parsa A, Sanagou M, Parsa CF (2007) Central corneal thickness and correlation to disc size: a potential link for susceptibility to glaucoma. Br J Ophthalmol 91:26–28PubMedCrossRef

29.

Medeiros FA, Sample PA, Weinreb RN (2003) Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes. Ophthalmology 110:1903–1908PubMedCrossRef

30.

Henderson PA, Medeiros FA, Zangwill LM, Weinreb RN (2005) Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients. Ophthalmology 112:251–256PubMedCrossRef

31.

Kim JW, Chen PP (2004) Central corneal pachymetry and visual field progression in patients with open-angle glaucoma. Ophthalmology 111:2126–2132PubMedCrossRef

32.

Brandt JD, Beiser JA, Kass MA, Gordon MO (2001) Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 108:1779–1788PubMedCrossRef

33.

Foster P, Baasanhu J, Alsbirk PH, Munkhbayar D, Uranchimeg D, Johnson GJ (1998) Central corneal thickness and intraocular pressure in a Mongolian population. Ophthalmology 105:969–973PubMedCrossRef

34.

Leung DY, Lam DK, Yeung BY, Lam DS (2006) Comparison between central corneal thickness measurements by ultrasound pachymetry and optical coherence tomography. Clin Experiment Ophthalmol 34:751–754PubMedCrossRef

Title: Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study
Authors: Haitao Zhang
Liang Xu
Changxi Chen
Jost B. Jonas
Publication date: 01-04-2008
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-007-0760-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2008

Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration

Cataract and mortality. The Beijing eye study

Intravitreal bevacizumab with or without triamcinolone for refractory diabetic macular edema; a placebo-controlled, randomized clinical trial

Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs

Brown cornea

The effect of single and repeated UVB radiation on rabbit lens