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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-01-2008 | Clinical Investigation

Characteristics of dynamic processing in the visual field of patients with age-related maculopathy

Authors: Werner Eisenbarth, Manfred MacKeben, Dorothe A. Poggel, Hans Strasburger

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2008

Abstract

Purpose

To investigate the characteristics of dynamic processing in the visual field of patients with age-related maculopathy (ARM) by measuring motion sensitivity, double-pulse resolution (DPR), and critical flicker fusion.

Methods

Fourteen subjects with ARM (18 eyes), 14 age-matched controls (19 eyes), and 7 young controls (8 eyes) served as subjects. Motion contrast thresholds were determined by a four-alternative forced-choice (4 afc) staircase procedure with a modification by Kernbach for presenting a plaid (size = 3.8°) moving within a stationary spatial and temporal Gaussian envelope in one of four directions. Measurements were performed on the horizontal meridian at 10°, 20°, 30°, 40°, and 60° eccentricity. DPR was defined as the minimal temporal gap detectable by the subject using a 9-fold interleaved adaptive procedure, with stimuli positioned on concentric rings at 5°, 10°, and 20° eccentricity on the principal and oblique meridians. Critical flicker fusion thresholds (CFF) and the Lanthony D-15 color vision test were applied foveally, and the subjects were free to use their fovea or whatever retinal area they needed to use instead, due to their retinal lesions caused by ARM. All measurements were performed under photopic conditions.

Results

Motion contrast sensitivity in subjects with ARM was pronouncedly reduced (0.23–0.66 log units, p < 0.01), not only in the macula but in a region up to 20° eccentricity. In the two control groups, motion contrast sensitivity systematically declined with retinal eccentricity (0.009–0.032 log units/degree) and with age (0.01 log units/year). Double-pulse thresholds in healthy subjects were approximately constant in the central visual field and increased outside a radius of 10° (1.73 ms/degree). DPR thresholds were elevated in subjects with ARM (by 23–32 ms, p < 0.01) up to 20° eccentricity, and their foveal CFFs were increased by 5.5 Hz or 14% (p < 0.01) as compared with age-matched controls.

Conclusions

Dynamic processing properties in subjects with ARM are severely impaired in the central visual field up to 20° eccentricity, which is clearly beyond the borders of the macula.

Adams AJ, Haegerstrom-Portnoy G (1987) Color deficiency. In: Amos JF (ed) Diagnosis and management in vision care. Butterworths, Stoneham

Alm A, Ehinger BEJ (2003) Retina. In: Kaufman PL, Alm A (eds) Adler’s physiology of the eye. Mosby, St. Louis, p 319–422

Altpeter E, MacKeben M, Trauzettel-Klosinski S (2000) The importance of sustained attention for patients with maculopathies. Vis Res 40:1539–1547PubMedCrossRef

Bach M, Meigen T, Strasburger H (1997) Raster-scan cathode-ray tubes for vision research—limits of resolution in space, time and intensity, and some solutions. Spat Vis 10:403–414PubMed

Bartlett H, Eperjesi F (2003) A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology. Nutr J 2:12

Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, de Jong PT, Klaver CC, Klein BE, Klein R (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol 39:367–374PubMedCrossRef

Bressler S, Bressler N, Gragoudas E (1994) Age-related macular degeneration: choroidal neovascularization. In: Albert DM, Jakobiec FA (eds) Principles and practice of ophthalmology. WB Saunders Company, Philadelphia

Bressler SB, Bressler NM, Gragoudas ES (1994) Age-related macular degeneration: Drusen and geographic atrophy. In: Albert DM, Jakobiec FA (eds) Principles and practice of ophthalmology. WB Saunders Company, Philadelphia, p 826–852

Brown B, Adams AJ, Coletta NJ, Haegerstrom-Portnoy G (1986) Dark adaptation in age-related maculopathy. Ophthalmic Physiol Opt 6:81–84

10.

Brown B, Brabyn L, Welch L, Haegerstrom-Portnoy G, Colenbrander A (1986) Contribution of vision variables to mobility in age-related maculopathy. Am J Optom Physiol Opt 63:733–739PubMed

11.

Brown B, Lovie-Kitchin JE (1987) Temporal function in age-related maculopathy. Clin Exp Optom 70:112–116CrossRef

12.

Curcio C, Medeiros NE, Millican CL (1996) Photoreceptor loss in age-related macular degeneration. Investig Ophthalmol Vis Sci 37:1236–1249

13.

Falsini B, Fadda A, Iarossi G, Piccardi M, Canu D, Minnella A, Serrao S, Scullica L (2000) Retinal sensitivity to flicker modulation: reduced by early age-related maculopathy. Invest Ophthalmol Vis Sci 41:498–506

14.

Frennesson C, Nilsson UL, Nilsson SE (1995) Colour contrast sensitivity in patients with soft drusen, an early stage of ARM. Doc Ophthalmol 90:377–386PubMedCrossRef

15.

Gabor D (1946) Theory of communication. J Inst Electr Eng 93(III):429–457

16.

Gofen A, MacKeben M (1997) An introduction to accurate display timing for PCs under ‘Windows’. Spat Vis 10:361–368PubMed

17.

Goldberg J, Flowerdew G, Smith E, Brody JA, Tso MO (1988) Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey. Am J Epidemiol 128:700–710PubMed

18.

Haegerstrom-Portnoy G, Schneck ME, Brabyn JA (1999) Seeing into old age: vision function beyond acuity. Optom Vis Sci 76:141–158PubMedCrossRef

19.

Hammond BJ, Wooten B (2005) CFF thresholds: relation to macular pigment optical density. Ophthalmic Physiol Opt 25(4):315–319PubMedCrossRef

20.

Harvey LO Jr (1986) Efficient estimation of sensory thresholds. Behav Res Meth Instr Comp 18:623–632

21.

Hassan SE, Lovie-Kitchin JE, Woods RL (2002) Vision and mobility performance of subjects with age-related macular degeneration. Optom Vis Sci 79:697–707PubMedCrossRef

22.

Hogan MJ, Alvarado JA, Weddell JE (1971) Histology of the human eye. W. B. Saunders, Philadelphia

23.

Holopigian K, Seiple W, Greenstein V, Kim D, Carr RE (1997) Relative effects of aging and age-related macular degeneration on peripheral visual functions. Optom Vis Sci 74:152–159PubMedCrossRef

24.

Hyvärinen L (1999) Visual perception in "low vision". Perception 28:1533–1537PubMedCrossRef

25.

Irtel H (1997) PXL: a library for psychological experiments on IBM PC type computers. Spat Vis 10:467–469PubMed

26.

Jonasson F, Thordarson K (1987) Prevalence of ocular disease and blindness in a rural area in the eastern region of Iceland during 1980 through 1984. Acta Ophthalmol Scand 182(suppl):40–43

27.

Jonides J, Yantis S (1988) Uniqueness of abrupt visual onset in capturing attention. Percept Psychophys 43:346–354PubMed

28.

Kaernbach C (2001) Adaptive threshold estimation with unforced-choice tasks. Percept Psychophys 63:1377–1388PubMed

29.

Kaernbach C (1991) Simple adaptive testing with the weighted up-down method. Percept Psychophys 49:227–229PubMed

30.

Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, Dawber TR (1977) The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study. Am J Epidemiol 106:33–41PubMed

31.

Kaplan E, Lee BB, Shapley RM (1990) New views of primate retinal function. In: Osborne N, Chader J (eds) Progress in retinal research. Pergamon Press, Oxford, p 273–336

32.

Kesten H (1958) Accelerated stochastic approximation. Ann Math Stat 29:41–59

33.

Klein R, Klein BE, Linton KL (1992) Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 99:933–943PubMed

34.

Klein R, Peto T, Bird A, Vannewkirk M (2004) The epidemiology of age-related macular degeneration. Am J Ophthalmol 137:486–495PubMedCrossRef

35.

Kuyk T, Elliott JL (1999) Visual factors and mobility in persons with age-related macular degeneration. J Rehabil Res Dev 36:303–312PubMed

36.

Lappin JS, Craft WD (2000) Foundations of spatial vision: from retinal images to perceived shapes. Psychol Rev 107:6–38PubMedCrossRef

37.

Lappin JS, Tadin D, Whittier EJ (2002) Visual coherence of moving and stationary image changes. Vis Res 42:523–534

38.

MacKeben M, Nakayama K (1993) Express attentional shifts. Vis Res 33:85–90PubMedCrossRef

39.

Marron JA, Bailey IL (1982) Visual factors and orientation-mobility performance. Am J Optom Physiol Opt 59:413–426PubMed

40.

Mayer MJ, Spiegler SJ, Ward B, Glucs A, Kim CB (1992) Mid-frequency loss of foveal flicker sensitivity in early stages of age-related maculopathy. Investig Ophthalmol Vis Sci 33:3136–3142

41.

Mayer MJ, Ward B, Klein R, Talcott JB, Dougherty RF, Glucs A (1994) Flicker sensitivity and fundus appearance in pre-exudative age-related maculopathy. Investig Ophthalmol Vis Sci 35:1138–1149

42.

Midena E, Degli Angeli C, Blarzino MC, Valenti M, Segato T (1997) Macular function impairment in eyes with early age-related macular degeneration. Investig Ophthalmol Vis Sci 38:469–477

43.

Nakayama K, Loomis JM (1974) Optical velocity patterns, velocity-sensitive neurons, and space perception: a hypothesis. Perception 3:63–80PubMedCrossRef

44.

Nakayama K, MacKeben M (1989) Sustained and transient components of focal visual attention. Vis Res 29:1631–1647PubMedCrossRef

45.

Owsley C, Sekuler R, Siemsen D (1983) Contrast sensitivity throughout adulthood. Vis Res 23:689–699PubMedCrossRef

46.

Poggel DA, Strasburger H (2004) Visual perception in time and space—mapping the visual field of temporal resolution. Acta Neurobiol Exp 64:427–437

47.

Poggel DA, Strasburger H, MacKeben M (2007) Cueing attention by relative motion in the periphery of the visual field. Perception 36(7):955–970

48.

Poggel DA, Treutwein B, Calmanti C, Strasburger H (2005) The Toelz temporal topography study: mapping the visual field across the life span. J Vision 4(11):76

49.

Sachs H (1995) Die Erkennbarkeit zeitlicher Doppelpulse im zentralen Gesichtsfeld: Grundlagen und klinische Anwendung. Akademischer Verlag, München

50.

Stelmach LB, Drance SM, Di Lollo V (1986) Two-pulse temporal resolution in patients with glaucoma, suspected glaucoma, and in normal observers. Am J Ophthalmol 102:617–620PubMed

51.

Strasburger H (ed) (1997) Use of computers and cathode-ray-tube displays in visual psychophysics. Part I. VSP, AH Zeist, The Netherlands

52.

Strasburger H (ed) (1997) Use of computers and cathode-ray-tube displays in visual psychophysics. Part II. VSP, AH Zeist, The Netherlands

53.

Strasburger H, Grundler W, Burgard E (2006) Kognitive Tests aussagekräftiger. Studien zur Validierung von Instrumenten der Seh- und Eignungsdiagnostik. (Cognitive tests are more predictive: Validation of instruments for assessing driving fitness.) Ophthalmologische Nachrichten 09/2006, Kongressausgabe 2:30

54.

Strasburger H, Wüstenberg T, Jäncke L (2002) Calibrated LCD/TFT stimulus presentation for visual psychophysics in fMRI. J Neurosci Methods 121:103–110PubMedCrossRef

55.

Sunness JS, Massof RW, Johnson MA, Finkelstein D, Fine SL (1985) Peripheral retinal function in age-related macular degeneration. Arch Ophthalmol 103:811–816PubMed

56.

Thorn F, Thorn S (1989) Speechreading with reduced vision: a problem of aging. J Opt Soc Am A 6(4):491–499PubMed

57.

Tikellis G, Robman LD, Harper A, McNeil JJ, Taylor HR, McCarty CA (2000) Methods for detecting age-related maculopathy: a comparison between photographic and clinical assessment. Clin Experiment Ophthalmol 28:367–372PubMedCrossRef

58.

Treutwein B (1995) Adaptive psychophysical procedures. Vis Res 35:2503–2522PubMed

59.

Treutwein B (1997) YAAP: yet another adaptive procedure. Spat Vis 11:129–134PubMed

60.

Treutwein B, Rentschler I (1992) Double-pulse resolution in the visual field: The influence of temporal stimulus characteristics. Clin Vis Sci 7:421–434

61.

Tyler CW (1989) Two processes control variations in flicker sensitivity over the live span. J Opt Soc Am A 6:481–490PubMed

62.

Vingerling JR, Dielemans I, Hofman A, Grobbee DE, Hijmering M, Kramer CF, de Jong PT (1995) The prevalence of age-related maculopathy in the Rotterdam study. Ophthalmology 102:205–210PubMed

63.

Watson AB (1980) Summation and discrimination of gratings moving in opposite directions. Vis Res 20:341–347PubMedCrossRef

Title: Characteristics of dynamic processing in the visual field of patients with age-related maculopathy
Authors: Werner Eisenbarth
Manfred MacKeben
Dorothe A. Poggel
Hans Strasburger
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-007-0641-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Characteristics of dynamic processing in the visual field of patients with age-related maculopathy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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