Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 5/2006

01-05-2006 | Clinical Investigation

No changes in anatomical and functional glaucoma evaluation after trabeculectomy

Authors: Ivan Maynart Tavares, Luiz Alberto S. Melo Jr, João A. Prata Jr, Roberta Galhardo, Augusto Paranhos Jr, Paulo Augusto A. Mello

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2006

Login to get access

Abstract

Purpose

To assess the influence of glaucoma filtration surgery on anatomical and functional tests for glaucoma evaluation.

Methods

Twenty-five eyes (25 patients) with primary open-angle glaucoma were evaluated, prospectively. Data were collected on vision acuity, intraocular pressure, standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry (GDx) and confocal scanning laser ophthalmoscopy (HRT II) before and 3–6 months after surgery.

Results

Mean (±SD) pre- and postoperative visual acuities (logMAR) were 0.28 (±0.18) and 0.30 (±0.17), respectively (P=0.346). In a mean time of 4.5 (±1.1) months after surgery, the mean preoperative intraocular pressure of 20.7 (±5.4) mmHg decreased to 11.04 (±2.52) mmHg (P<0.001). The results of the standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry and confocal scanning laser ophthalmoscopy diagnostic methods revealed no significant difference (P>0.162) between pre and postoperative values and no significant correlation (P>0.296) between intraocular pressure reduction and value changes.

Conclusion

No significant change on any test variable was detected after glaucoma filtration surgery. Trabeculectomy does not appear to influence standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry and confocal scanning laser ophthalmoscopy (HRT II) results after a 4.5-month period of surgery in early to moderate glaucoma.
Literature
1.
Aydin A, Wollstein G, Price LL, Fujimoto JG, Schuman JS (2003) Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery. Ophthalmology 110:1506–1511CrossRefPubMed
2.
Burgoyne CF, Quigley HA, Thompson HW, Vitale S, Varma R (1995) Early changes in optic disc compliance and surface position in experimental glaucoma. Ophthalmology 102:1800–1809PubMed
3.
Coleman AL, Quigley HA, Vitale S, Dunkelberger G (1991) Displacement of the optic nerve head by acute changes in intraocular pressure in monkey eyes. Ophthalmology 98:35–40PubMed
4.
Costa VP, Smith M, Spaeth GL, Gandham S, Markovitz B (1993) Loss of visual acuity after trabeculectomy. Ophthalmology 100:599–612PubMed
5.
Gandolfi SA (1995) Improvement of visual field indices after surgical reduction of intraocular pressure. Ophthalmic Surg 26:121–126PubMed
6.
Greenfield DS, Knighton RW (2001) Stability of corneal polarization axis measurements for scanning laser polarimetry. Ophthalmology 108:1065–1069CrossRefPubMed
7.
Irak I (2000) Longitudinal changes in optic disc topography of adult patients after trabeculectomy. Ophthalmology 107:407CrossRefPubMed
8.
Irak I, Zangwill L, Garden V, Shakiba S, Weinreb RN (1996) Change in optic disk topography after trabeculectomy. Am J Ophthalmol 122:690–695PubMed
9.
Lesk MR, Spaeth GL, Azuara-Blanco A, Araujo SV, Katz LJ, Terebuh AK, Wilson RP, Moster MR, Schmidt CM (1999) Reversal of optic disc cupping after glaucoma surgery analyzed with a scanning laser tomograph. Ophthalmology 106:1013–1018CrossRefPubMed
10.
Medeiros FA, Borges AS, Susanna Jr R (2001) Alterações longitudinais na espessura da camada de fibras nervosas da retina após trabeculectomia. Rev Bras Oftalmol 60:619–627
11.
Minckler DS, Bunt AH (1977) Axoplasmic transport in ocular hypotony and papilledema in the monkey. Arch Ophthalmol 95:1430–1436PubMed
12.
Paranhos Jr A, Lima M, Salim S, Osorio P, Caprioli J, Shields MB (2005) Quantitaive analysis of disc measures by Heidelberg Retina Tomograph before and after trabeculectomy. Braz J Med Biol Res (in press)
13.
Quigley H, Anderson DR (1976) The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. Invest Ophthalmol 15:606–616PubMed
14.
Quigley HA (1982) Childhood glaucoma: results with trabeculotomy and study of reversible cupping. Ophthalmology 89:219–226PubMed
15.
Salim S, Paranhos A, Lima M, Shields MB (2001) Influence of surgical reduction of intraocular pressure on regions of the visual field with different levels of sensitivity. Am J Ophthalmol 132:496–500CrossRefPubMed
16.
Sogano S, Tomita G, Kitazawa Y (1993) Changes in retinal nerve fiber layer thickness after reduction of intraocular pressure in chronic open-angle glaucoma. Ophthalmology 100:1253–1258PubMed
17.
The Advanced Glaucoma Intervention Study (AGIS): 12 (2002) Baseline risk factors for sustained loss of visual field and visual acuity in patients with advanced glaucoma. Am J Ophthalmol 134:499–512CrossRef
18.
Topouzis F, Peng F, Kotas-Neumann R, Garcia R, Sanguinet J, Yu F, Coleman AL (1999) Longitudinal changes in optic disc topography of adult patients after trabeculectomy. Ophthalmology 106:1147–1151CrossRefPubMed
19.
Trible JR, Schultz RO, Robinson JC, Rothe TL (2000) Accuracy of glaucoma detection with frequency-doubling perimetry. Am J Ophthalmol 129:740–745CrossRefPubMed
20.
Tsai CS, Shin DH, Wan JY, Zeiter JH (1991) Visual field global indices in patients with reversal of glaucomatous cupping after intraocular pressure reduction. Ophthalmology 98:1412–1419PubMed
21.
Yamada N, Tomita G, Yamamoto T, Kitazawa Y (2000) Changes in the nerve fiber layer thickness following a reduction of intraocular pressure after trabeculectomy. J Glaucoma 9:371–375PubMed
22.
Zangwill L, Irak I, Berry CC, Garden V, de Souza Lima M, Weinreb RN (1997) Effect of cataract and pupil size on image quality with confocal scanning laser ophthalmoscopy. Arch Ophthalmol 115:983–990PubMed
Metadata
Title
No changes in anatomical and functional glaucoma evaluation after trabeculectomy
Authors
Ivan Maynart Tavares
Luiz Alberto S. Melo Jr
João A. Prata Jr
Roberta Galhardo
Augusto Paranhos Jr
Paulo Augusto A. Mello
Publication date
01-05-2006
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2006
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-005-0104-6

Other articles of this Issue 5/2006

Graefe's Archive for Clinical and Experimental Ophthalmology 5/2006 Go to the issue

Book Review

Frank G. Holz, Richard F. Spaide (Eds) Medical Retina (Essentials in Ophthalmology series)

Clinical Investigation

Short-wavelength automated perimetry in patients with migraine

Clinical Investigation

Changes in the lens epithelium with respect to cataractogenesis—light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics

Clinical Investigation

First experiences with high-density silicone oil (Densiron) as an intraocular tamponade in complex retinal detachment

Announcements

Announcements

Clinical Investigation

Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial