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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2004 | Review Article

Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features

Authors: Sarah E. Coupland, Heinrich Heimann, Nikolaos E. Bechrakis

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2004

Abstract

Introduction

Primary intraocular lymphoma (PIOL) is a rare non-Hodgkin lymphoma which arises in the retina or the vitreous. It can occur either together with or independently of primary cerebral nervous system lymphoma (PCNSL); the incidence of the latter has significantly increased over the past three decades. PIOL remains one of the most difficult diagnoses to establish, particularly due to its ability to mimic other diseases in the eye and to the limited material which is often available for examination.

Methods

The article reviews the clinical, histopathological, molecular biological and biochemical approaches to the diagnosis of PIOL. The differential diagnoses, including other lymphomatous manifestations in the eye, e.g. primary uveal lymphoma, as well as non-neoplastic uveal diseases are addressed. Furthermore, the treatment strategies for PIOL are summarised.

Results

Diagnostic progress has been made in various fields, including flow cytometry and immunocytology, cytokine analysis, and as well as molecular biological analysis of the immunoglobulin heavy and light chains using polymerase chain reaction on both fixed and non-fixed material. The optimal therapy of PIOL remains to be determined: the current trends suggest that combined radiotherapy and chemotherapy, as well as intravitreal chemotherapy, are of value. Novel therapies which may have a role in the future include oral trofosfamide.

Conclusion

Our understanding of the pathogenesis of PIOL/PCNSL remains far from complete. Intensified efforts must be made to determine the cell of origin of PIOL, as well as to establish “molecular signatures”, which could be used to decrease diagnostic delay. Further studies, possibly prospective ones, are required to establish the optimal therapy for initial and recurrent disease.

Abrey LE, DeAngelis LM, Yahalom J (1998) Long-term survival in primary CNS lymphoma. J Clin Oncol 16:859–863PubMed

Akpek EK, Ahmed I, Hochberg FH et al (1999) Intraocular-central nervous system lymphoma: clinical features, diagnosis, and outcomes. Ophthalmology 106:1805–1810CrossRefPubMed

Anagnostopoulos I, Stein H (2000) Large B-cell lymphomas: variants and entities. Pathologe 21:178–189CrossRefPubMed

Appen RE (1975) Posterior uveitis and primary cerebral reticulum cell sarcoma. Arch Ophthalmol 93:123–124PubMed

Barr CC, Green WR, Payne JW et al (1975) Intraocular reticulum-cell sarcoma: clinico-pathologic study of four cases and review of the literature. Surv Ophthalmol 19:224–239PubMed

Basso U, Brandes AA (2002) Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma. Eur J Cancer 38:1298–1312CrossRefPubMed

Batchelor TT, Kolak G, Ciordia R et al (2003) High-dose methotrexate for intraocular lymphoma. Clin Cancer Res 9:711–715PubMed

Baumann MA, Ritch PS, Hande KR et al (1986) Treatment of intraocular lymphoma with high-dose Ara-C. Cancer 57:1273–1275PubMed

Beasley H (1961) Lymphosarcoma of the choroid. Am J Ophthalmol 51:1294–1296PubMed

10.

Bechrakis NE, Foerster MH, Bornfeld N (2002) Biopsy in indeterminate intraocular tumors. Ophthalmology 109:235–242CrossRefPubMed

11.

Ben-Ezra D, Sahel JA, Harris NL et al (1989) Uveal lymphoid infiltrates: immunohistochemical evidence for a lymphoid neoplasia. Br J Ophthalmol 73:846–851PubMed

12.

Brown SM, Jampol LM, Cantrill HL (1994) Intraocular lymphoma presenting as retinal vasculitis. Surv Ophthalmol 39:133–140CrossRefPubMed

13.

Buggage RR, Chan CC, Nussenblatt RB (2001) Ocular manifestations of central nervous system lymphoma. Curr Opin Oncol 13:137–142CrossRefPubMed

14.

Cassoux N, Merle-Beral H, Leblond V et al (2000) Ocular and central nervous system lymphoma: clinical features and diagnosis. Ocul Immunol Inflamm 8:243–250CrossRefPubMed

15.

Chan CC, Buggage RR, Nussenblatt RB (2002) Intraocular lymphoma. Curr Opin Ophthalmol 13:411–418CrossRefPubMed

16.

Chan CC, Whitcup SM, Solomon D, Nussenblatt RB (1995) Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. Am J Ophthalmol 120:671–673PubMed

17.

Chang TS, Byrne SF, Gass JD et al (1996) Echographic findings in benign reactive lymphoid hyperplasia of the choroid. Arch Ophthalmol 114:669–675PubMed

18.

Char DH, Ljung BM, Deschenes J, Miller TR (1988) Intraocular lymphoma: immunological and cytological analysis. Br J Ophthalmol 72:905–911PubMed

19.

Char DH, Ljung BM, Miller T, Phillips T (1988) Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. Ophthalmology 95:625–630PubMed

20.

Char DH, Margolis L, Newman AB (1981) Ocular reticulum cell sarcoma. Am J Ophthalmol 91:480–483PubMed

21.

Cheung MK, Martin DF, Chan CC et al (1994) Diagnosis of reactive lymphoid hyperplasia by chorioretinal biopsy. Am J Ophthalmol 118:457–462PubMed

22.

Ciricillo SF, Rosenblum ML (1990) Use of CT and MR imaging to distinguish intracranial lesions and to define the need for biopsy in AIDS patients. J Neurosurg 73:720–724

23.

Ciulla TA, Bains RA, Jakobiec FA et al (1997) Uveal lymphoid neoplasia: a clinical-pathologic correlation and review of the early form. Surv Ophthalmol 41:467–476CrossRefPubMed

24.

Ciulla TA, Pesavento RD, Yoo S (1997) Subretinal aspiration biopsy of ocular lymphoma. Am J Ophthalmol 123:420–422PubMed

25.

Cochereau I, Hannouche D, Geoffray C et al (1996) Ocular involvement in Epstein–Barr virus-associated T-cell lymphoma. Am J Ophthalmol 121:322–324PubMed

26.

Cockerham GC, Hidayat AA, Bijwaard KE, Sheng ZM (2000) Re-evaluation of “reactive lymphoid hyperplasia of the uvea”: an immunohistochemical and molecular analysis of 10 cases. Ophthalmology 107:151–158CrossRefPubMed

27.

Cook C (1954) Uveal lymphosarcoma. Br J Ophthalmol 38:182–185PubMed

28.

Cooper EL, Riker JL (1951) Malignant lymphoma of the uveal tract. Am J Ophthalmol 34:1153–1158PubMed

29.

Corn BW, Donahue BR, Rosenstock JG et al (1997) Performance status and age as independent predictors of survival among AIDS patients with primary CNS lymphoma: a multivariate analysis of a multi-institutional experience. Cancer J Sci Am 3:52–56PubMed

30.

Corriveau C, Easterbrook M, Payne D (1986) Lymphoma simulating uveitis (masquerade syndrome). Can J Ophthalmol 21:144–149PubMed

31.

Coupland SE, Anastassiou G, Hummel M, Stein H Primary intraocular lymphoma of T-cell type: report of a case and review of the literature. Graefe’s Arch Clin Exp Ophthalm DOI 10.1007/s00417-004-0890-2 (in press)

32.

Coupland SE, Bechrakis NE, Anastassiou G et al (2003) Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. Graefes Arch Clin Exp Ophthalmol 10:860–870CrossRef

33.

Coupland SE, Foss HD, Assaf C et al (1999) T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases. Ophthalmology 106:2109–2120CrossRefPubMed

34.

Coupland SE, Foss HD, Bechrakis NE et al (2001) Secondary ocular involvement in systemic “memory” B-cell lymphocytic leukemia. Ophthalmology 108:1289–1295CrossRefPubMed

35.

Coupland SE, Foss HD, Hidayat AA et al (2002) Extranodal marginal zone B cell lymphomas of the uvea: an analysis of 13 cases. J Pathol 197:333–340CrossRefPubMed

36.

Coupland SE, Willerding G, Jahnke K, Stoltenburg-Didinger G, Hummel M, Stein H (2004) Demonstration of identical clonal derivation in a case of “oculocerebral” lymphoma. Br J Ophthamol (in press)

37.

Crookes GP, Mullaney J (1967) Lymphoid hyperplasia of the uveal tract simulating malignant lymphoma. Am J Ophthalmol 63:962–967PubMed

38.

Davis JL, Solomon D, Nussenblatt RB et al (1992) Immunocytochemical staining of vitreous cells. Indications, techniques, and results. Ophthalmology 99:250–256PubMed

39.

Davis JL, Viciana AL, Ruiz P (1997) Diagnosis of intraocular lymphoma by flow cytometry. Am J Ophthalmol 124:362–372PubMed

40.

Dean JM, Novak MA, Chan CC, Green WR (1996) Tumor detachments of the retinal pigment epithelium in ocular/ central nervous system lymphoma. Retina 16:47–56PubMed

41.

DeAngelis LM (1994) Primary central nervous system lymphoma. Recent Results Cancer Res 135:155–169PubMed

42.

DeAngelis LM (1999) Primary central nervous system lymphoma. Curr Opin Neurol 12:687–691CrossRefPubMed

43.

DeAngelis LM (2001) Primary central nervous system lymphomas. Curr Treat Options Oncol 2:309–318PubMed

44.

DeAngelis LM, Seiferheld W, Schold SC et al (2002) Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol 20:4643–4648CrossRefPubMed

45.

DeAngelis LM, Yahalom J, Thaler HT, Kher U (1992) Combined modality therapy for primary CNS lymphoma. J Clin Oncol 10:635–643PubMed

46.

Desroches G, Abrams GW, Gass JD (1983) Reactive lymphoid hyperplasia of the uvea. A case with ultrasonographic and computed tomographic studies. Arch Ophthalmol 101:725–728PubMed

47.

van Dongen JJ, Langerak AW, Bruggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257–2317CrossRefPubMed

48.

Duker JS, Shields JA, Eagle RC, Jr (1989) Ocular lymphoid hyperplasia. Arch Ophthalmol 107:446–447PubMed

49.

Duker JS, Shields JA, Ross M (1987) Intraocular large cell lymphoma presenting as massive thickening of the uveal tract. Retina 7:41–455PubMed

50.

Eby NL, Grufferman S, Flannelly CM et al (1988) Increasing incidence of primary brain lymphoma in the US. Cancer 62:2461–2465PubMed

51.

Engel HM, Green WR, Michels RG et al (1981) Diagnostic vitrectomy. Retina 1:121–149PubMed

52.

Erny BC, Egbert PR, Peat IM et al (1991) Intraocular involvement with subretinal pigment epithelium infiltrates by mycosis fungoides. Br J Ophthalmol 75:698–701 (Erratum 76(2):128)PubMed

53.

Escoffery RF, Bobrow JC, Smith ME (1985) Exudative retinal detachment secondary to orbital and intraocular benign lymphoid hyperplasia. Retina 5:91–93PubMed

54.

Falini B, Fizzotti M, Pucciarini A et al (2000) A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95:2084–2092PubMed

55.

Faulborn J, Daicker B, Bowald S (1983) Clinical signs and histopathology of so-called reticulum cell sarcoma of the eye. Klin Monatsbl Augenheilkd 183:120–121PubMed

56.

Feiden W, Milutinovic S (2002) Primary CNS lymphomas morphology and diagnosis. Pathologe 23:284–291CrossRefPubMed

57.

Ferreri AJ, Blay JY, Reni M (2002) Relevance of intraocular involvement in the management of primary central nervous system lymphomas. Ann Oncol 13:531–538CrossRefPubMed

58.

Feugier P, Virion JM, Tilly H et al (2004) Incidence and risk factors for central nervous system occurrence in elderly patients with diffuse large-B-cell lymphoma: influence of rituximab. Ann Oncol 15:129–133CrossRefPubMed

59.

Fine HA, Mayer RJ (1993) Primary central nervous system lymphoma. Ann Intern Med 119:1093–1104PubMed

60.

Fishburne BC, Wilson DJ, Rosenbaum JT, Neuwelt EA (1997) Intravitreal methotrexate as an adjunctive treatment of intraocular lymphoma. Arch Ophthalmol 115:1152–1156PubMed

61.

Foerster H (1960) Mycosis fungoides with intraocular involvement. Trans Am Acad Ophthalmol Otolaryngol 64:308–314PubMed

62.

Fredrick DR, Char DH, Ljung BM, Brinton DA (1989) Solitary intraocular lymphoma as an initial presentation of widespread disease. Arch Ophthalmol 107:395–397PubMed

63.

Freeman LN, Schachat AP, Knox DL et al (1987) Clinical features, laboratory investigations, and survival in ocular reticulum cell sarcoma. Ophthalmology 94:1631–1639PubMed

64.

Freilich RJ, DeAngelis LM (1995) Primary central nervous system lymphoma. Neurol Clin 13:901–914PubMed

65.

Freilich RJ, Delattre JY, Monjour A, DeAngelis LM (1996) Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients. Neurology 46:435–439PubMed

66.

Gärtner J (1989) Mycosis fungoides mit Beteiligung der Aderhaut. Klin Monatsbl Augenheilkd 131:61–69

67.

Gass JD (1967) Retinal detachment and narrow-angle glaucoma secondary to inflammatory pseudotumor of the uveal tract. Am J Ophthalmol 64(Suppl):612–621PubMed

68.

Gass JD, Sever RJ, Grizzard WS et al (1984) Multifocal pigment epithelial detachments by reticulum cell sarcoma. A characteristic funduscopic picture. Retina 4:135–143PubMed

69.

Gass JD, Trattler HL (1991) Retinal artery obstruction and atheromas associated with non-Hodgkin’s large cell lymphoma (reticulum cell sarcoma). Arch Ophthalmol 109:1134–1139PubMed

70.

Gill MK, Jampol LM (2001) Variations in the presentation of primary intraocular lymphoma: case reports and a review. Surv Ophthalmol 45:463–471CrossRefPubMed

71.

Goeminne JC, Brouillard A, Jaumain P et al (1999) Bilateral granulomatous panuveitis as initial presentation of diffuse systemic T cell lymphoma. Ophthalmologica 213:323–326CrossRefPubMed

72.

Goldey SH, Stern GA, Oblon DJ et al (1989) Immunophenotypic characterization of an unusual T-cell lymphoma presenting as anterior uveitis. A clinicopathologic case report. Arch Ophthalmol 107:1349–1353PubMed

73.

Gorochov G, Parizot C, Bodaghi B et al (2003) Characterization of vitreous B-cell infiltrates in patients with primary ocular lymphoma, using CDR3 size polymorphism analysis of antibody transcripts. Invest Ophthalmol Vis Sci 44:5235–5241CrossRefPubMed

74.

Grossniklaus HE, Martin DF, Avery R et al (1998) Uveal lymphoid infiltration. Report of four cases and clinicopathologic review. Ophthalmology 105:1265–1273CrossRefPubMed

75.

Helbig H, Cerny T, De Smet MD (2003) Intravitreal chemotherapy for intraocular lymphoma. Ophthalmologe 100:145–149CrossRefPubMed

76.

Henry JM, Heffner RR Jr, Dillard SH et al (1974) Primary malignant lymphomas of the central nervous system. Cancer 34:1293–1302PubMed

77.

Herrlinger U, Schabet M, Bitzer M et al (1999) Primary central nervous system lymphoma: from clinical presentation to diagnosis. J Neurooncol 43:219–226

78.

Hochberg FH, Miller DC (1988) Primary central nervous system lymphoma. J Neurosurg 68:835–853

79.

Hoffman PM, McKelvie P, Hall AJ et al (2003) Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes. Eye 17:513–521CrossRefPubMed

80.

Holz FG, Boehmer HV, Mechtersheimer G et al (1999) Uveal non-Hodgkin’s lymphoma with epibulbar extension simulating choroidal effusion syndrome. Retina 19:343–346PubMed

81.

Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World Health Organization classification of tumours. Tumours of haematopoietic and lymphoid tissues. Pathology and genetics. IARC, Lyon

82.

Jahnke K, Bechrakis NE, Coupland SE, et al (2004) Trofosfamide for relapsed intraocular lymphoma: case report and review of the literature. Graefes Arch Clin Exp Ophthalmol 242:771–776CrossRef

83.

Jakobiec FA, Sacks E, Kronish JW et al (1987) Multifocal static creamy choroidal infiltrates. An early sign of lymphoid neoplasia. Ophthalmology 94:397–406PubMed

84.

Jensen OA, Johansen S, Kiss K (1994) Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of the literature. Graefes Arch Clin Exp Ophthalmol 232:148–152CrossRefPubMed

85.

Kaplan HJ, Meredith TA, Aaberg TM, Keller RH (1980) Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma). Immunologic characterization of vitreous cells. Arch Ophthalmol 98:707–710PubMed

86.

Katai N, Kuroiwa S, Fujimori K, Yoshimura N (1997) Diagnosis of intraocular lymphoma by polymerase chain reaction. Graefes Arch Clin Exp Ophthalmol 235:431–436PubMed

87.

Kawai Y, Kawai R, Nakayama T et al (1999) Successful treatment of cytomegalovirus retinitis in a patient with malignant lymphoma: a case report and review of the literature. Int J Hematol 69:256–259PubMed

88.

Keltner JL, Fritsch E, Cykiert RC, Albert DM (1977) Mycosis fungoides. Intraocular and central nervous system involvement. Arch Ophthalmol 95:645–650PubMed

89.

Kincaid ME, Green WR (1983) Ocular and orbital involvement in leukemia. Surv Ophthalmol 27:211–232CrossRefPubMed

90.

Kirmani MH, Thomas EL, Rao NA, Laborde RP (1987) Intraocular reticulum cell sarcoma: diagnosis by choroidal biopsy. Br J Ophthalmol 71:748–752PubMed

91.

Klingele TG, Hogan MJ (1975) Ocular reticulum cell sarcoma. Am J Ophthalmol 79:39–47PubMed

92.

Kohno T, Uchida H, Inomata H et al (1993) Ocular manifestations of adult T-cell leukemia/lymphoma. A clinicopathologic study. Ophthalmology 100:1794–1799PubMed

93.

Kuker W, Herrlinger U, Gronewaller E et al (2002) Ocular manifestation of primary nervous system lymphoma: what can be expected from imaging? J Neurol 249:1713–1716

94.

Kumar SR, Gill PS, Wagner DG et al (1994) Human T-cell lymphotropic virus type I-associated retinal lymphoma. A clinicopathologic report. Arch Ophthalmol 112:954–959PubMed

95.

Lafaut BA, Hanssens M, Verbraeken H, De Laey JJ (1994) Chorioretinal biopsy in the diagnosis of intraocular lymphoma: a case report. Bull Soc Belge Ophtalmol 252:67–73PubMed

96.

Leitch RJ, Rennie IG, Parsons MA (1993) Ocular involvement in mycosis fungoides. Br J Ophthalmol 77:126–127PubMed

97.

Levy-Clarke GA, Byrnes GA, Buggage RR et al (2001) Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion. Retina 21:281–284CrossRefPubMed

98.

Ljung BM, Char D, Miller TR, Deschenes J (1988) Intraocular lymphoma. Cytologic diagnosis and the role of immunologic markers. Acta Cytol 32:840–847PubMed

99.

Lobo A, Larkin G, Clark BJ et al (2003) Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. Clin Exp Ophthalmol 31:155–158CrossRef

100.

Lobo A, Lightman S (2003) Vitreous aspiration needle tap in the diagnosis of intraocular inflammation. Ophthalmology 110:595–599CrossRefPubMed

101.

Lois N, Hiscott PS, Nash J, Wong D (2000) Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion. Arch Ophthalmol 118:1692–1694PubMed

102.

Margolis L, Fraser R, Lichter A, Char DH (1980) The role of radiation therapy in the management of ocular reticulum cell sarcoma. Cancer 45:688–692PubMed

103.

Martin DF, Chan CC, de Smet MD et al (1993) The role of chorioretinal biopsy in the management of posterior uveitis. Ophthalmology 100:705–714PubMed

104.

Mason JO, Fischer DH (2003) Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma. Ophthalmology 110:1241–1244CrossRefPubMed

105.

McGavic JS (1943) Lymphomatoid diseases involving the eye and its adnexa. Arch Ophthalmol 30:179–193

106.

Merchant A, Foster CS (1997) Primary intraocular lymphoma. Int Ophthalmol Clin 37:101–115PubMed

107.

Merle-Beral H, Davi F, Cassoux N et al (2004) Biological diagnosis of primary intraocular lymphoma. Br J Haematol 124:469–473PubMed

108.

Michels RG, Knox DL, Erozan YS, Green WR (1975) Intraocular reticulum cell sarcoma. Diagnosis by pars plana vitrectomy. Arch Ophthalmol 93:1331–1335PubMed

109.

Nathwani BN, Kim H, Rappaport H et al (1978) Non-Hodgkin’s lymphomas: a clinicopathologic study comparing two classifications. Cancer 41:303–325PubMed

110.

Nelson DF, Martz KL, Bonner H et al (1992) Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 23:9–17PubMed

111.

Palexas GN, Green WR, Goldberg MF, Ding Y (1995) Diagnostic pars plana vitrectomy report of a 21-year retrospective study. Trans Am Ophthalmol Soc 93:281–308 (Discussion 308–314)PubMed

112.

Parver LM, Font RL (1979) Malignant lymphoma of the retina and brain. Initial diagnosis by cytologic examination of vitreous aspirate. Arch Ophthalmol 97:1505–1507

113.

Pavan PR, Oteiza EE, Margo CE (1995) Ocular lymphoma diagnosed by internal subretinal pigment epithelium biopsy. Arch Ophthalmol 113:1233–1234PubMed

114.

Pels H, Schmidt-Wolf IG, Glasmacher A et al (2003) Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol 21:4489–4495 (e-pub 3 Nov 2003)CrossRefPubMed

115.

Peterson K, Gordon KB, Heinemann MH, DeAngelis LM (1993) The clinical spectrum of ocular lymphoma. Cancer 72:843–849PubMed

116.

Plowman PN, Montefiore DS, Lightman S (1993) Multiagent chemotherapy in the salvage cure of ocular lymphoma relapsing after radiotherapy. Clin Oncol R Coll Radiol 5:315–316PubMed

117.

Qualman SJ, Mendelsohn G, Mann RB, Green WR (1983) Intraocular lymphomas. Natural history based on a clinicopathologic study of eight cases and review of the literature. Cancer 52:878–886PubMed

118.

Read RW, Zamir E, Rao NA (2002) Neoplastic masquerade syndromes. Surv Ophthalmol 47:81–124CrossRefPubMed

119.

Reim H, Dieler R, Wessing A (1990) Non-Hodgkin’s lymphoma simulating chorioretinitis. Fortschr Ophthalmol 87:557–559PubMed

120.

Ridley ME, McDonald HR, Sternberg P Jr et al (1992) Retinal manifestations of ocular lymphoma (reticulum cell sarcoma). Ophthalmology 99:1153–1160 (Discussion 1160–1161)PubMed

121.

Rosenthal AR (1983) Ocular manifestations of leukemia. Ophthalmology 90:899–905PubMed

122.

Rothova A, Ooijman F, Kerkhoff F et al (2001) Uveitis masquerade syndromes. Ophthalmology 108:386–399CrossRefPubMed

123.

Rubenstein JL, Combs D, Rosenberg J et al (2003) Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood 101:466–468 (e-pub 5 Sep 2002)CrossRefPubMed

124.

Ryan SJ Jr, Frank RN, Green WR (1971) Bilateral inflammatory pseudotumors of the ciliary body. Am J Ophthalmol 72:586–591PubMed

125.

Ryan SJ, Zimmerman LE, King FM (1972) Reactive lymphoid hyperplasia. An unusual form of intraocular pseudotumor. Trans Am Acad Ophthalmol Otolaryngol 76:652–671PubMed

126.

Saga T, Ohno S, Matsuda H et al (1984) Ocular involvement by a peripheral T-cell lymphoma. Arch Ophthalmol 102:399–402PubMed

127.

Schachat AP, Markowitz JA, Guyer DR et al (1989) Ophthalmic manifestations of leukemia. Arch Ophthalmol 107:697–700PubMed

128.

Scroggs MW, Johnston WW, Klintworth GK (1990) Intraocular tumors. A cytopathologic study. Acta Cytol 34:401–408PubMed

129.

Shen DF, Zhuang Z, LeHoang P et al (1998) Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. Ophthalmology 105:1664–1669CrossRefPubMed

130.

Shields JA, Augsburger JJ, Gonder JR, MacLeod D (1981) Localized benign lymphoid tumor of the iris. Arch Ophthalmol 99:2147–2148PubMed

131.

Shields JA, McDonald PR (1974) Improvements in the diagnosis of posterior uveal melanomas. Arch Ophthalmol 91:259–264PubMed

132.

de Smet MD, Nussenblatt RB, Davis JL, Palestine AG (1990) Large cell lymphoma masquerading as a viral retinitis. Int Ophthalmol 14:413–417

133.

Soussain C, Merle-Beral H, Reux I et al (1996) A single-center study of 11 patients with intraocular lymphoma treated with conventional chemotherapy followed by high-dose chemotherapy and autologous bone marrow transplantation in 5 cases. Leuk Lymphoma 23:339–345PubMed

134.

Soussain C, Suzan F, Hoang-Xuan K et al (2001) Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma. J Clin Oncol 19:742–749PubMed

135.

Stenson S, Ramsay DL (1981) Ocular findings in mycosis fungoides. Arch Ophthalmol 99:272–277PubMed

136.

Strauchen JA, Dalton J, Friedman AH (1989) Chemotherapy in the management of intraocular lymphoma. Cancer 63:1918–1921PubMed

137.

Triebenstein O (1920) Ein Beitrag zur Frage der aleukämischen Augenveränderungen. Klin Monatsbl Augenheilkd 64:825–836

138.

Umland O, Ulmer AJ, Vollmer E, Goldmann T (2003) HOPE fixation of cytospin preparations of human cells for in situ hybridization and immunocytochemistry. J Histochem Cytochem 51:977–980PubMed

139.

Ursea R, Heinemann MH, Silverman RH et al (1997) Ophthalmic, ultrasonographic findings in primary central nervous system lymphoma with ocular involvement. Retina 17:118–123PubMed

140.

Valluri S, Moorthy RS, Khan A, Rao NA (1995) Combination treatment of intraocular lymphoma. Retina 15:125–129PubMed

141.

Velez G, Chan CC, Csaky KG (2002) Fluorescein angiographic findings in primary intraocular lymphoma. Retina 22:37–43PubMed

142.

Velez G, de Smet MD, Whitcup SM et al (2000) Iris involvement in primary intraocular lymphoma: report of two cases and review of the literature. Surv Ophthalmol 44:518–526CrossRefPubMed

143.

Verbraeken HE, Hanssens M, Priem H et al (1997) Ocular non-Hodgkin’s lymphoma: a clinical study of nine cases. Br J Ophthalmol 81:31–36PubMed

144.

Wender A, Adar A, Maor E, Yassur Y (1994) Primary B-cell lymphoma of the eyes and brain in a 3-year-old boy. Arch Ophthalmol 112:450–451PubMed

145.

Whitcup SM, de Smet MD, Rubin BI et al (1993) Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology 100:1399–1406PubMed

146.

Whitcup SM, Stark-Vancs V, Wittes RE et al (1997) Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma. Arch Ophthalmol 115:1157–1160PubMed

147.

White VA, Gascoyne RD, Paton KE (1999) Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. Arch Ophthalmol 117:761–765PubMed

148.

Williams GC, Holz E, Lee AG, Font RL (2000) T-cell lymphoproliferative disorder of vitreous associated with mycosis fungoides. Arch Ophthalmol 118:278–280PubMed

149.

Wolter J, Leenhouts T, Hendrix R (1963) Corneal involvement in mycosis fungoides. Am J Ophthalmol 55:315–322

150.

Wylen EL, Williams RB, Nanda A (1998) Cutaneous T-cell lymphoma with intracerebral and bilateral intraocular spread. Neurol Res 20:307–312PubMed

151.

Yahalom C, Cohen Y, Averbukh E et al (2002) Bilateral iridociliary T-cell lymphoma. Arch Ophthalmol 120:204–207PubMed

152.

Yamada K, Hirata A, Kimura A, Tanihara H (2003) A case of primary B-cell type non-Hodgkin lymphoma originating in the iris. Am J Ophthalmol 136:380–382CrossRefPubMed

153.

Young TL, Himelstein BP, Rebsamen SL et al (1996) Intraocular Ki-1 lymphoma in a 2-year-old boy. J Pediatr Ophthalmol Strabismus 33:268–270PubMed

154.

Yunis JJ, Oken MM, Kaplan ME et al (1982) Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin’s lymphoma. N Engl J Med 307:1231–1236

155.

Zauberman H, Freund M (1971) Pseudolymphoma of the choroid in a patient with senile disciform macular degeneration. Ophthalmologica 163:65–72PubMed

Title: Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features
Authors: Sarah E. Coupland
Heinrich Heimann
Nikolaos E. Bechrakis
Publication date: 01-11-2004
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2004
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-004-0973-0

ACC 2024 Congress

Springer Medicine

Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features

Abstract

Introduction

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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