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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2004

01-11-2004 | Clinical Investigation

The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer

Authors: Peter Jeppesen, Pernille A Gregersen, Toke Bek

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2004

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Abstract

Purpose

To study the age-dependent change in myogenic response of retinal arterioles.

Methods

Fifty-one healthy volunteers with at least ten persons in each of the five age decades (I–V) between 20 and 69 years were subjected to diameter measurement of retinal arterioles using the Retinal Vessel Analyzer (RVA) during rest and during an increase in the systemic blood pressure when lifting hand weights. The transmural pressure in the retinal arterioles during the procedures was estimated from the blood pressure and the intraocular pressure and was compared to the accompanying diameter response.

Results

The retinal arteriolar diameter showed a significant decrease as a function of increasing weight for the two younger age groups below the age of 40 years (P=0.007, group I, and P=0.049, group II), compatible with perfect autoregulation, whereas no such change was observed in persons above this age (P=0.41, 0.053, 0.29 for groups III–V, respectively).

Conclusion

Studies on autoregulation in retinal disease should consider the normal age-related decrease in diameter response of retinal arterioles when the blood pressure is changed.
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Metadata
Title
The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer
Authors
Peter Jeppesen
Pernille A Gregersen
Toke Bek
Publication date
01-11-2004
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2004
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-004-0945-4

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