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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2004 | Short Communication

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

Authors: Simone Eperon, Alain Sauty, René Lanz, Annette Leimgruber, Floriana Lurati, Yan Guex-Crosier

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2004

Abstract

Purpose

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.

Methods

Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level.

Results

Eotaxin-1 concentration in tears of SAC patients [2,100±503 (SEM) pg/ml] and normal subjects (1,193±176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024).

Conclusions

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

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Title: Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis
Authors: Simone Eperon
Alain Sauty
René Lanz
Annette Leimgruber
Floriana Lurati
Yan Guex-Crosier
Publication date: 01-11-2004
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2004
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-004-0943-6

At a glance: The STEP trials

Springer Medicine

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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