Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2004

01-11-2004 | Short Communication

Plasticity of polypoidal lesions in polypoidal choroidal vasculopathy

Authors: Akiko Okubo, Munefumi Sameshima, Taiji Sakamoto

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2004

Login to get access

Abstract

Purpose

The aim of this study was to describe the clinical course in a patient with polypoidal choroidal vasculopathy (PCV).

Methods

A 68-year-old man with PCV in the left eye was followed up by means of routine examinations including fluorescein angiography and indocyanine green angiography for over 60 months.

Results

Throughout the follow-up period, the patient experienced repeated lesions in the macula, such as serosanguineous detachment of the retinal pigment epithelium and neurosensory retina, but retained good visual acuity. Indocyanine green angiography disclosed spontaneous regression of polypoidal vessels followed by significant changes in the choroidal circulation: a group of polypoidal structures disappeared, and after several months a small choroidal vessel became apparent that was distant from the previously observed polypoidal structure rather than representing an extension of the original lesion.

Conclusion

The clinical observation suggests that in some cases of PCV the choroidal vasculature may be altered with time, in that some vessels in the inner choroid and even the choriocapillaris may close and collateral vessels and/or new vessels may develop to form complex such as that described here.
Literature
1.
go back to reference Ahuja RM, Stanga PE, Vingerling JR, Reck AC, Bird AC (2000) Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments. Br J Ophthalmol 84:479–484PubMed Ahuja RM, Stanga PE, Vingerling JR, Reck AC, Bird AC (2000) Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments. Br J Ophthalmol 84:479–484PubMed
2.
go back to reference Bowers DK, Finkelstein D, Wolff SM, Green WR (1987) Branch retinal vein occlusion. A clinicopathologic case report. Retina 7:252–259PubMed Bowers DK, Finkelstein D, Wolff SM, Green WR (1987) Branch retinal vein occlusion. A clinicopathologic case report. Retina 7:252–259PubMed
3.
go back to reference Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653–660 Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653–660
4.
go back to reference Frangieh GT, Green WR, Barraquer-Somers E, Finkelstein D (1982) Histopathologic study of nine branch retinal vein occlusions. Arch Ophthalmol 100:1132–1140PubMed Frangieh GT, Green WR, Barraquer-Somers E, Finkelstein D (1982) Histopathologic study of nine branch retinal vein occlusions. Arch Ophthalmol 100:1132–1140PubMed
5.
go back to reference Fryczkowski AW (1997) The choriocapillaris: anatomic and functional choroidal lobules. In: Yannuzzi LA, Flower RW, Slakter JS (eds) Indocyanine green angiography. Mosby, St. Louis, pp 29–35 Fryczkowski AW (1997) The choriocapillaris: anatomic and functional choroidal lobules. In: Yannuzzi LA, Flower RW, Slakter JS (eds) Indocyanine green angiography. Mosby, St. Louis, pp 29–35
6.
go back to reference Helisch A, Schaper W (2003) Arteriogenesis: the development and growth of collateral arteries. Microcirculation 10:83–97CrossRefPubMed Helisch A, Schaper W (2003) Arteriogenesis: the development and growth of collateral arteries. Microcirculation 10:83–97CrossRefPubMed
7.
go back to reference Kleiner RC, Brucker AJ, Johnston RL (1990) The posterior uveal bleeding syndrome. Retina 10:9–17PubMed Kleiner RC, Brucker AJ, Johnston RL (1990) The posterior uveal bleeding syndrome. Retina 10:9–17PubMed
8.
go back to reference Lafaut BA, Leyes AM, Snyers B, Rasquin F, De Laey JJ (2000) Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Clin Exp Ophthalmol 238:752–759CrossRefPubMed Lafaut BA, Leyes AM, Snyers B, Rasquin F, De Laey JJ (2000) Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Clin Exp Ophthalmol 238:752–759CrossRefPubMed
9.
go back to reference Michels RG, Gass JDM (1974) The natural course of retinal branch vein obstruction. Trans Am Acad Ophthalmol Otolaryngol 78:166-177 Michels RG, Gass JDM (1974) The natural course of retinal branch vein obstruction. Trans Am Acad Ophthalmol Otolaryngol 78:166-177
10.
go back to reference Okubo A, Sameshima M, Uemura A, Kanda S, Ohba N (2002) Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study. Br J Ophthalmol 86:1093-1098CrossRefPubMed Okubo A, Sameshima M, Uemura A, Kanda S, Ohba N (2002) Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study. Br J Ophthalmol 86:1093-1098CrossRefPubMed
11.
go back to reference Perkovich BT, Zakov ZN, Berlin LA, Weidenthal D, Avins LR (1990) An update on multiple recurrent serosanguineous retinal pigment epithelial detachments in black women. Retina 10:18–26PubMed Perkovich BT, Zakov ZN, Berlin LA, Weidenthal D, Avins LR (1990) An update on multiple recurrent serosanguineous retinal pigment epithelial detachments in black women. Retina 10:18–26PubMed
12.
go back to reference Spaide RF, Yannuzzi LA, Slakter JS, Sorenson JA, Orlock DA (1995) Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina 15:100–110PubMed Spaide RF, Yannuzzi LA, Slakter JS, Sorenson JA, Orlock DA (1995) Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina 15:100–110PubMed
13.
go back to reference Stern RM, Zakov ZN, Zegarra H, Gutman FA (1985) Multiple recurrent serosanguineous retinal pigment epithelial detachments in black woman. Am J Ophthalmol 100:560–569PubMed Stern RM, Zakov ZN, Zegarra H, Gutman FA (1985) Multiple recurrent serosanguineous retinal pigment epithelial detachments in black woman. Am J Ophthalmol 100:560–569PubMed
14.
go back to reference Uyama M, Matsubara T, Fukushima I, Matsunaga H, Iwashita K, Nagai Y, Takahashi K (1999) Idiopathic polypoidal choroidal vasculopathy in Japanese patients. Arch Ophthalmol 117:1035–1042PubMed Uyama M, Matsubara T, Fukushima I, Matsunaga H, Iwashita K, Nagai Y, Takahashi K (1999) Idiopathic polypoidal choroidal vasculopathy in Japanese patients. Arch Ophthalmol 117:1035–1042PubMed
15.
go back to reference Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, Takahashi K, Matsumura M (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639–648CrossRefPubMed Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, Takahashi K, Matsumura M (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639–648CrossRefPubMed
16.
go back to reference Yannuzzi LA, Sorenson J, Spaide RF, Lipson B (1990) Idiopathic choroidal vasculopathy (IPCV). Retina 10:1–8PubMed Yannuzzi LA, Sorenson J, Spaide RF, Lipson B (1990) Idiopathic choroidal vasculopathy (IPCV). Retina 10:1–8PubMed
17.
go back to reference Yannuzzi LA, Wong DWK, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, Freund KB, Slakter JS, Guyer DR, Sorenson JA, Fisher Y, Maberley D, Orlock DA (1999) Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol 117:1503–1510PubMed Yannuzzi LA, Wong DWK, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, Freund KB, Slakter JS, Guyer DR, Sorenson JA, Fisher Y, Maberley D, Orlock DA (1999) Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol 117:1503–1510PubMed
Metadata
Title
Plasticity of polypoidal lesions in polypoidal choroidal vasculopathy
Authors
Akiko Okubo
Munefumi Sameshima
Taiji Sakamoto
Publication date
01-11-2004
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2004
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-004-0920-0

Other articles of this Issue 11/2004

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2004 Go to the issue

Announcements

November 2004