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01-06-2020 | Multiple Sclerosis | Original Communication

Cerebellar gray matter lesions are common in pediatric multiple sclerosis at clinical onset

Authors: Monica Margoni, Silvia Franciotta, Davide Poggiali, Alice Riccardi, Francesca Rinaldi, Margherita Nosadini, Stefano Sartori, Maria Giulia Anglani, Francesco Causin, Paola Perini, Paolo Gallo

Published in: Journal of Neurology | Issue 6/2020

Abstract

Background

No data are available on the occurrence of gray matter lesions (GML) in the cerebellum of pediatric multiple sclerosis (pedMS).

Objectives

We analyzed frequency, number and topography of GML, and their correlation with cerebellar-related disability in pedMS at clinical onset.

Methods

Fifteen adolescents with pedMS (12F/3M; mean age 14.9 ± 2.2, range 11–17) were studied. Neurological and cognitive evaluations were done by means of EDSS, Trail Making Test—Part B (TMT-B) and Symbol Digit Modalities Test—oral version (SDMT). Cerebellar GML were investigated with double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) sequences obtained with a 3 T-MRI scan.

Results

All patients had white matter lesions (WML) and/or GML in the cerebellum. A significantly higher GML number was observed on PSIR compared to DIR (mean 2.3 ± 2.3 vs 1.1 ± 1.6; median 2.0 (IQR 1.0–2.0) vs 1.0 (IQR 0.0–1.5); p = 0.004). GML were observed in 14/15 (93.3%) patients and were more frequent in the posterior than in the anterior lobe (mean 1.8 ± 2.2 vs 0.47 ± 0.74; median 2.0 (IQR 0.5–2.0) vs 0.0 (IQR 0.0–1.0); p = 0.044). No correlation was found between lesion number or topography and EDSS (r = 0.12, p = 0.69), TMT-B and SDMT.

Conclusion

At clinical onset, cerebellar GML are common in pedMS, are very often asymptomatic, do not correlate with physical and cognitive disability, and more frequently affect the posterior lobe.

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Title: Cerebellar gray matter lesions are common in pediatric multiple sclerosis at clinical onset
Authors: Monica Margoni
Silvia Franciotta
Davide Poggiali
Alice Riccardi
Francesca Rinaldi
Margherita Nosadini
Stefano Sartori
Maria Giulia Anglani
Francesco Causin
Paola Perini
Paolo Gallo
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keyword: Multiple Sclerosis
Published in: Journal of Neurology / Issue 6/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09776-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Cerebellar gray matter lesions are common in pediatric multiple sclerosis at clinical onset

Abstract

Background

Objectives

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusion

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