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Journal of Neurology

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Open Access 01-06-2021 | Stroke | Review

“Smoking paradox” is not true in patients with ischemic stroke: a systematic review and meta-analysis

Authors: Bo Li, Dan Li, Jing-Feng Liu, Lin Wang, Bao-Zhu Li, Xiu-Juan Yan, Wei Liu, Kun Wu, Ruo-Lan Xiang

Published in: Journal of Neurology | Issue 6/2021

Abstract

Background

Ischemic stroke (IS) is a common cause of death from vascular diseases. Studies have found that smoking increases the risk of ischemic stroke, but the association of smoking with the outcome of IS remains unclear. This meta-analysis aims to investigate the effect of smoking on the prognosis of IS.

Methods

We searched four electronic databases including PubMed, EMBASE, Cochrane library and Web of science for papers, published before January 2019. In this meta-analysis, Review Manager 5.3 software was used to calculate for the pooled estimate effect, as well as the inverse-variance method for pooled mean difference (MD) and odds ratio (OR) of incidence in two groups of population.

Results

A total of 14,789 citations were identified during the literature search, 21 studies were included in the meta-analyses after screening. The full-adjusted OR of poor prognostic outcome in smoking and nonsmoking patients with stroke was pooled as 0.96 (95% CI 0.77–1.21), suggested that smoking or not has no impact on prognosis of IS. The pooled MD of onset age between smoking and nonsmoking IS patients was − 10.05 (− 12.91, − 7.19), indicated that smoking causes first onset of IS to occur 10 years earlier.

Conclusions

This meta-analysis showed that smoking was not a protective factor for poor prognosis of IS. Smoking patients with IS are 10 years younger than nonsmoking patients at time of the first onset of stroke.

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Title: “Smoking paradox” is not true in patients with ischemic stroke: a systematic review and meta-analysis
Authors: Bo Li
Dan Li
Jing-Feng Liu
Lin Wang
Bao-Zhu Li
Xiu-Juan Yan
Wei Liu
Kun Wu
Ruo-Lan Xiang
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keyword: Stroke
Published in: Journal of Neurology / Issue 6/2021
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-019-09596-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

“Smoking paradox” is not true in patients with ischemic stroke: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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