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01-08-2018 | Original Communication

Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML

Authors: Jeremias Motte, Janina Kneiphof, Katrin Straßburger-Krogias, Anja Klasing, Ortwin Adams, Aiden Haghikia, Ralf Gold

Published in: Journal of Neurology | Issue 8/2018

Abstract

We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF.

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Title: Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML
Authors: Jeremias Motte
Janina Kneiphof
Katrin Straßburger-Krogias
Anja Klasing
Ortwin Adams
Aiden Haghikia
Ralf Gold
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 8/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8931-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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