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Open Access 01-07-2018 | Journal club

Transmissible amyloid protein: evidence from iatrogenic CJD

Authors: Mo Hu, Neil P. Robertson

Published in: Journal of Neurology | Issue 7/2018

Excerpt

Creutzfeldt–Jakob disease (CJD) is a progressive neurodegenerative condition caused by the accumulation of toxic forms of prion protein in the brain. In 1985, reports emerged of patients who had developed CJD following treatment with cadaveric human growth hormone contaminated with prion protein, suggesting a transmissible aetiology. More recently detailed pathological analyses of brain tissue in these patients have unexpectedly revealed the co-existence of amyloid-beta protein (Aβ), the most common misfolded protein seen in the ageing brain, which is also implicated in the aetiology of Alzheimer’s disease and cerebral amyloid angiopathy. …

Title: Transmissible amyloid protein: evidence from iatrogenic CJD
Authors: Mo Hu
Neil P. Robertson
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 7/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8927-3

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Transmissible amyloid protein: evidence from iatrogenic CJD

Excerpt

ACC 2024 Congress

Springer Medicine

Excerpt

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