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Open Access 01-08-2016 | Letter to the Editors

l-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS

Authors: Miyuki Kitamura, Shuichi Yatsuga, Toshi Abe, Nataliya Povalko, Reo Saiki, Kikumi Ushijima, Yushiro Yamashita, Yasutoshi Koga

Published in: Journal of Neurology | Issue 8/2016

Excerpt

Dear Sirs, …

Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP (1984) Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 16:481–488. doi:10.1002/ana.410160409 CrossRefPubMed

Yoneda M, Maeda M, Kimura H, Fujii H, Katayama K, Kuriyama M (1999) Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging. Neurology 53:2182–2184. doi:10.1212/WNL.53.9.2182 CrossRefPubMed

Iizuka T, Sakai F (2010) Pathophysiology of stroke-like episodes in MELAS: neuron–astrocyte uncoupling in neuronal hyperexcitability. Future Neurol 5:61–83. doi:10.2217/fnl.09.71 CrossRef

Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Fukiyma R et al (2006) Endothelial dysfunction in MELAS was improved by l-arginine supplementation. Neurology 66:1766–1769. doi:10.1212/01.wnl.0000220197.36849.1e CrossRefPubMed

Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y et al (2005) l-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology 64:710–712. doi:10.1212/01.WNL.0000151976.60624.01 CrossRefPubMed

Kim JH, Lim MK, Jeon TY, Rha JH, Eo H, Yoo SY et al (2011) Diffusion and perfusion characteristics of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-lie episodes) in thirteen patients. Korean J Radiol 12:15–24. doi:10.3348/kjr.2011.12.1.15 CrossRefPubMedPubMedCentral

Title: l-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS
Authors: Miyuki Kitamura
Shuichi Yatsuga
Toshi Abe
Nataliya Povalko
Reo Saiki
Kikumi Ushijima
Yushiro Yamashita
Yasutoshi Koga
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 8/2016
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-016-8069-4

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l-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS

Excerpt

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Excerpt

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