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Journal of Neurology
Published in: Journal of Neurology 8/2014

01-08-2014 | Original Communication

Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation

Authors: Franca Tecchio, Andrea Cancelli, Carlo Cottone, Giancarlo Zito, Patrizio Pasqualetti, Anna Ghazaryan, Paolo Maria Rossini, Maria Maddalena Filippi

Published in: Journal of Neurology | Issue 8/2014

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Abstract

Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
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Metadata
Title
Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation
Authors
Franca Tecchio
Andrea Cancelli
Carlo Cottone
Giancarlo Zito
Patrizio Pasqualetti
Anna Ghazaryan
Paolo Maria Rossini
Maria Maddalena Filippi
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 8/2014
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-014-7377-9

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