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Journal of Neurology
Published in: Journal of Neurology 2/2014

01-02-2014 | Review

Recent advances in Parkinson’s disease genetics

Authors: Steven Lubbe, Huw R. Morris

Published in: Journal of Neurology | Issue 2/2014

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Abstract

The last 5 years have seen rapid progress in Parkinson’s disease (PD) genetics, with the publication of a series of large-scale genome wide association studies for PD, and evaluation of the roles of the LRRK2 and GBA genes in the aetiology of PD. We are beginning to develop a coherent picture of the interplay of Mendelian and non-Mendelian factors in PD. Pathways involved in mitochondrial quality control (mitophagy), lysosomal function and immune function are emerging as important in the pathogenesis of PD. These pathways represent a target for therapeutic intervention and a way in which the heterogeneity of disease cause, as well as disease mechanism, can be established. In the future, there is likely to be an individualised basis for the treatment of PD, linked to the identification of specific genetic factors.
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Metadata
Title
Recent advances in Parkinson’s disease genetics
Authors
Steven Lubbe
Huw R. Morris
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 2/2014
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-013-7003-2

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