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Open Access 01-08-2013 | Original Communication

Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients

Authors: Tetsutaro Ozawa, Jun Tokunaga, Musashi Arakawa, Atsushi Ishikawa, Ryoko Takeuchi, Naomi Mezaki, Takeshi Miura, Naoko Sakai, Mariko Hokari, Akari Takeshima, Kota Utsumi, Takashi Kondo, Akio Yokoseki, Masatoyo Nishizawa

Published in: Journal of Neurology | Issue 8/2013

Abstract

Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (n = 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (n = 24), and control subjects (n = 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %, P = 0.001) and control subjects (mean: 13.9 %, P = 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (r = −0.5, P = 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.

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Title: Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients
Authors: Tetsutaro Ozawa
Jun Tokunaga
Musashi Arakawa
Atsushi Ishikawa
Ryoko Takeuchi
Naomi Mezaki
Takeshi Miura
Naoko Sakai
Mariko Hokari
Akari Takeshima
Kota Utsumi
Takashi Kondo
Akio Yokoseki
Masatoyo Nishizawa
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 8/2013
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-013-6944-9

At a glance: The STEP trials

Springer Medicine

Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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