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01-07-2013 | Original Communication

Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia

Authors: Sze-Cheen Low, Louise A. Corben, Martin B. Delatycki, Anne-Marie Ternes, Patricia K. Addamo, Nellie Georgiou-Karistianis

Published in: Journal of Neurology | Issue 7/2013

Abstract

This study sought to characterise force variability and motor overflow in 12 individuals with Friedreich ataxia (FRDA) and 12 age- and gender-matched controls. Participants performed a finger-pressing task by exerting 30 and 70 % of their maximum finger force using the index finger of the right and left hand. Control of force production was measured as force variability, while any involuntary movements occurring on the finger of the other, passive hand, was measured as motor overflow. Significantly greater force variability in individuals with FRDA compared with controls is indicative of cortico-cerebellar disruption affecting motor control. Meanwhile, significantly greater motor overflow in this group provides the first evidence of possible abnormal inter-hemispheric activity that may be attributable to asymmetrical neuronal loss in the dentate nucleus. Overall, this study demonstrated a differential engagement in the underlying default processes of the motor system in FRDA.

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Title: Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia
Authors: Sze-Cheen Low
Louise A. Corben
Martin B. Delatycki
Anne-Marie Ternes
Patricia K. Addamo
Nellie Georgiou-Karistianis
Publication date: 01-07-2013
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 7/2013
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-013-6869-3

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Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia

Abstract

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