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01-01-2013 | Original Communication

Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease

Authors: Manuela Pilleri, Silvia Facchini, Elisabetta Gasparoli, Roberta Biundo, Laura Bernardi, Mauro Marchetti, Patrizia Formento, Angelo Antonini

Published in: Journal of Neurology | Issue 1/2013

Abstract

Orthostatic hypotension (OH) is a frequent nonmotor feature of Parkinson’s disease (PD), and its occurrence has been associated with cognitive impairment. The underlying mechanism could be mediated by development of cerebrovascular disease induced by chronic or episodic hypoperfusion, but the extent of brain vascular load in PD patients with OH has never been investigated. This study aimed to assess the relationship between OH and cognitive function in PD patients and to investigate the contribution of brain vascular lesions. Forty-eight PD patients underwent a tilt table test (TT) to assess supine and orthostatic blood pressure as well as an extensive neuropsychological evaluation to evaluate cognitive function. Brain magnetic resonance imaging was acquired in 44/48 patients and analyzed by a visual semiquantitative scale. Twenty-three patients presented OH at TT (13/23 were symptomatic), and 25 did not. There were no differences in motor severity or disease duration between patients with and without OH. In patients with OH we found significantly worse cognitive performance in specific tasks, such as sustained attention, visuospatial and verbal memory, compared with patients without OH. However, there were no differences in vascular burden between the two groups. Our study confirms that there is an association between OH and selective cognitive deficits in PD, but rebuts the hypothesis that this is underlined by the development of cerebrovascular disease.

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Title: Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease
Authors: Manuela Pilleri
Silvia Facchini
Elisabetta Gasparoli
Roberta Biundo
Laura Bernardi
Mauro Marchetti
Patrizia Formento
Angelo Antonini
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 1/2013
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-012-6627-y

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Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease

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