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Journal of Neurology
Published in: Journal of Neurology 11/2012

01-11-2012 | Letter to the Editors

4-Aminopyridine and cerebellar gait: a retrospective case series

Authors: Roman Schniepp, Max Wuehr, Maximilian Neuhaeusser, Ann Kathrin Benecke, Christine Adrion, Thomas Brandt, Michael Strupp, Klaus Jahn

Published in: Journal of Neurology | Issue 11/2012

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Excerpt

Dear Sirs, …
Appendix
Available only for authorised users
Literature
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Alvina K, Khodakhah K (2010) The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia. J Neurosci 30:7258–7268PubMedCrossRef
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Goodman AD, Brown TR, Edwards KR, Krupp LB, Schapiro RT, Cohen R, Marinucci LN, Blight AR (2010) A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. Ann Neurol 68:494–502PubMedCrossRef
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Ilg W, Brotz D, Burkard S, Giese MA, Schols L, Synofzik M (2010) Long-term effects of coordinative training in degenerative cerebellar disease. Mov Disord 25:2239–2246PubMedCrossRef
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Ilg W, Golla H, Thier P, Giese MA (2007) Specific influences of cerebellar dysfunctions on gait. Brain 130:786–798PubMedCrossRef
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Ilg W, Synofzik M, Brotz D, Burkard S, Giese MA, Schols L (2009) Intensive coordinative training improves motor performance in degenerative cerebellar disease. Neurology 73:1823–1830PubMedCrossRef
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Kalla R, Glasauer S, Buttner U, Brand T, Strupp M (2007) 4-Aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus. Brain 130:2441–2451PubMedCrossRef
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Schniepp R, Wuehr M, Ackl N, Danek A, Brandt T, Strupp M, Jahn K (2011) 4-Aminopyridine improves gait variability in cerebellar ataxia due to CACNA 1A mutation. J Neurol 258:1708–1711PubMedCrossRef
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Schniepp R, Wuehr M, Neuhaeusser M, Kamenova M, Dimitriadis K, Klopstock T, Strupp M, Brandt T, Jahn K (2012) Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure. Mov Disord 27(1):125–131PubMedCrossRef
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Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T (2004) Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine. Neurology 62:1623–1625PubMedCrossRef
Metadata
Title
4-Aminopyridine and cerebellar gait: a retrospective case series
Authors
Roman Schniepp
Max Wuehr
Maximilian Neuhaeusser
Ann Kathrin Benecke
Christine Adrion
Thomas Brandt
Michael Strupp
Klaus Jahn
Publication date
01-11-2012
Publisher
Springer-Verlag
Published in
Journal of Neurology / Issue 11/2012
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-012-6595-2

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