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Journal of Neurology
Published in: Journal of Neurology 12/2010

01-12-2010 | Letter to the Editors

Severe encephalopathy and polyneuropathy induced by dichloroacetate

Authors: Dieta Brandsma, Thomas P. C. Dorlo, John H. Haanen, Jos H. Beijnen, Willem Boogerd

Published in: Journal of Neurology | Issue 12/2010

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Excerpt

Dear Sirs, …
Literature
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Coglan A (2007) Cheap, ‘safe’ drug kills most cancers. New Scientist magazine 11
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Bonnet S, Archer SL, Allalunis-Turner J et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37–51CrossRefPubMed
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Michelakis ED, Webster L, Mackey JR (2008) Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 99:989–994CrossRefPubMed
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Michelakis ED, Sutendra G, Dromparis P et al (2010) Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2(31):31–34
5.
Stacpoole PW, Kerr DS, Barnes C et al (2006) Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 117:1519–1531CrossRefPubMed
6.
Kaufmann P, Engelstad K, Wei Y et al (2006) Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology 66:324–330CrossRefPubMed
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Shroads AL, Guo X, Dixit V, Liu HP, James MO, Stacpoole PW (2008) Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity. J Pharmacol Exp Ther 324:1163–1171CrossRefPubMed
Metadata
Title
Severe encephalopathy and polyneuropathy induced by dichloroacetate
Authors
Dieta Brandsma
Thomas P. C. Dorlo
John H. Haanen
Jos H. Beijnen
Willem Boogerd
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Journal of Neurology / Issue 12/2010
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-010-5654-9

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