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01-11-2009 | Letter to the editors

Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes

Authors: Sarah H. Ying, Bennett A. Landman, Shwetadwip Chowdhury, Alexander H. Sinofsky, Anna Gambini, Susumu Mori, David S. Zee, Jerry L. Prince

Published in: Journal of Neurology | Issue 11/2009

Abstract

The cerebellar peduncles are excellent candidates for composite indicators of regional degeneration in posterior fossa structures, as the peduncles show histopathological changes in degenerative ataxia. We postulate that magnetic resonance imaging will reveal evidence of disease specific peduncle degeneration through macrostructural (cross-sectional area) and microstructural (fractional anisotropy, mean diffusivity) measures. This study presents a “proof of principle” using orthogonal diffusion tensor imaging cross-sections of the cerebellar peduncles to distinguish categories of cerebellar disease.

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Title: Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes
Authors: Sarah H. Ying
Bennett A. Landman
Shwetadwip Chowdhury
Alexander H. Sinofsky
Anna Gambini
Susumu Mori
David S. Zee
Jerry L. Prince
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 11/2009
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-009-5269-1

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Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes

Abstract

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Abstract

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