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01-12-2009 | Original Communication

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)

Authors: Oscar Fernández, Alfredo R-Antigüedad, María Jesús Pinto-Medel, Mari Mar Mendibe, Nestor Acosta, Begoña Oliver, Miguel Guerrero, Marcos Papais-Alvarenga, Victoria Fernández-Sánchez, Laura Leyva

Published in: Journal of Neurology | Issue 12/2009

Abstract

Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major histocompatibility complex, particularly with the HLA DRB1*1501-DQA1*0102-DQB1*0602 haplotype in Caucasians. To investigate the association of DRB1, DQA1 and DQB1 alleles and haplotypes with MS in Biscay, Basque Country, northern Spain, we examined 197 patients and 200 regionally matched controls. High resolution HLA class II typing was performed by polymerase chain reaction followed by sequence-specific oligonucleotide probe hybridization. Several alleles were overrepresented in MS patients compared with those of controls: DRB1*0402, DRB1*1303, DRB1*1501, DQA1*0102, DQB1*0301, and DQB1*0602. DQB1*0602 was the only potentially predisposing allele for MS that withstood Bonferroni correction and maintained the association in a logistic regression model. On the other hand, several alleles showed lower frequencies in the MS group: DRB1*0101, DQA1*0101, DQB1*0303, and DQB1*0501, but only DRB1*0101 and DQB1*0303 maintained a negative association with the disease in the regression analysis. Three haplotypes were identified as potentially predisposing for MS in our population: DRB1*1501-DQA1*0102-DQB1*0602, DRB1*0402-DQA1*0301-DQB1*0302, and HLA-DRB1*013-DQA1*05-DQB1*0301. Additionally, three haplotypes associated with a lower risk for MS were identified, exhibiting DRB1*0101-DQA1*0101-DQB1*0501 the strongest negative association with MS [12% in controls vs. 3.8% in MS, P _c = 0.00047, OR = 0.290 (95% CI = 0.160–0.528)], and suggesting, therefore, a putative protective role for this haplotype in the population under study.

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Title: HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)
Authors: Oscar Fernández
Alfredo R-Antigüedad
María Jesús Pinto-Medel
Mari Mar Mendibe
Nestor Acosta
Begoña Oliver
Miguel Guerrero
Marcos Papais-Alvarenga
Victoria Fernández-Sánchez
Laura Leyva
Publication date: 01-12-2009
Publisher: D. Steinkopff-Verlag
Published in: Journal of Neurology / Issue 12/2009
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-009-5223-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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