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Journal of Neurology
Published in: Journal of Neurology 9/2009

01-09-2009 | Letter to the Editors

Downbeat nystagmus caused by a paramedian ponto-medullary lesion

Authors: Judith Wagner, Nadine Lehnen, Stefan Glasauer, Nicole Rettinger, Ulrich Büttner, Thomas Brandt, Michael Strupp

Published in: Journal of Neurology | Issue 9/2009

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Abstract

Downbeat nystagmus (DBN) is rarely caused by lesions in sites other than the cerebellar (para-)floccular lobe. We describe a case of DBN secondary to a hemorrhaged venous cavernoma at the pontomedullary junction. This case provides new insights into the neuro-anatomical substrate of DBN. We propose that DBN arises from lesions in a brainstem-cerebellar feedback loop, which comprises cells of the pontine paramedian tract (PMT).
Literature
1.
Bertholon P, Convers P, Barral FG et al (1993) Post-traumatic syringomyelobulbia and inferior vertical nystagmus. Rev Neurol (Paris) 149:355–358
2.
Glasauer S, Hoshi M, Kempermann U et al (2003) Three-dimensional eye position and slow phase velocity in humans with downbeat nystagmus. J Neurophysiol 89:338–354PubMedCrossRef
3.
de Jong JM, Cohen B, Matsuo V et al (1980) Midsagittal pontomedullary brain stem section: effects on ocular adduction and nystagmus. Exp Neurol 68:420–442PubMedCrossRef
4.
Nakamagoe K, Iwamoto Y, Yoshida K (2000) Evidence for brainstem structures participating in oculomotor integration. Science 288:857–859PubMedCrossRef
5.
Rousseaux M, Dupard T, Lesoin F, Barbaste P, Hache JC (1991) Upbeat and downbeat nystagmus occurring successively in a patient with posterior medullary haemorrhage. J Neurol Neurosurg Psychiatry 54:367–369PubMedCrossRef
6.
Yeow YK, Tjia TL (1989) The localizing value of downbeat nystagmus. Singapore Med J 30:273–276PubMed
Metadata
Title
Downbeat nystagmus caused by a paramedian ponto-medullary lesion
Authors
Judith Wagner
Nadine Lehnen
Stefan Glasauer
Nicole Rettinger
Ulrich Büttner
Thomas Brandt
Michael Strupp
Publication date
01-09-2009
Publisher
D. Steinkopff-Verlag
Published in
Journal of Neurology / Issue 9/2009
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-009-5153-z

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