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01-07-2019 | Autopsy | Method Paper

Post-mortem cerebrospinal fluid diagnostics: cytology and immunocytochemistry method suitable for routine use to interpret pathological processes in the central nervous system

Authors: Simone Bohnert, Benjamin Ondruschka, Michael Bohnert, Michael K. Schuhmann, Camelia-Maria Monoranu

Published in: International Journal of Legal Medicine | Issue 4/2019

Abstract

Due to its protected anatomical location, cerebrospinal fluid (CSF) is a very stable fluid which undergoes comparatively little change in the early post-mortem phase. While many immunohistochemical markers already established for clinical diagnostic issues in tissue samples obtained by biopsy could meanwhile be translated also to post-mortem tissue, no systematic immunocytochemical investigations have generally been conducted on post-mortem body fluids and for CSF specifically, have not been established at all. CSF as the fluid directly surrounding the brain should also be examined to allow a more detailed characterization of processes in the central nervous system. Comparing traumatized tissue and CSF can complete forensic assessment and complement neuropathological evaluation.

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Title: Post-mortem cerebrospinal fluid diagnostics: cytology and immunocytochemistry method suitable for routine use to interpret pathological processes in the central nervous system
Authors: Simone Bohnert
Benjamin Ondruschka
Michael Bohnert
Michael K. Schuhmann
Camelia-Maria Monoranu
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Autopsy
Forensic Assessment
Published in: International Journal of Legal Medicine / Issue 4/2019
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-019-02050-z

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Post-mortem cerebrospinal fluid diagnostics: cytology and immunocytochemistry method suitable for routine use to interpret pathological processes in the central nervous system

Abstract

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