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01-09-2019 | Population Data

Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil)

Authors: Juliana Martinez, Fernanda Silva Polverari, Flávia Alves de Jesus Silva, Danilo Faustino Braganholi, Joyce Aparecida Martins Lopes Ferraz, Leonor Gusmão, Regina Maria Barretto Cicarelli

Published in: International Journal of Legal Medicine | Issue 5/2019

Abstract

X-chromosomal markers can be useful in some forensic cases, where the analysis of the autosomal markers is not conclusive. In this study, a population sample of 500 unrelated individuals born in São Paulo State was characterized for 32 X-InDel markers. No deviations from the Hardy–Weinberg equilibrium were detected, except for MID1361. The 32 X-InDels showed an accumulated power of discrimination of 0.9999999999993 in females and 0.99999993 in males and an exclusion chance of 0.999996 in trios and 0.99995 in duos. São Paulo showed lower genetic distances to the Colombian admixed and European populations than to Native American, Asian, or African populations. Ancestry analysis revealed 41.8% European, 31.6% African, and 26.6% Native American contributions. Segregation analysis was performed in 101 trios, and the mutation rate was estimated to be low.

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Title: Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil)
Authors: Juliana Martinez
Fernanda Silva Polverari
Flávia Alves de Jesus Silva
Danilo Faustino Braganholi
Joyce Aparecida Martins Lopes Ferraz
Leonor Gusmão
Regina Maria Barretto Cicarelli
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 5/2019
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-018-01988-w

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Genetic characterization of 32 X-InDels in a population sample from São Paulo State (Brazil)

Abstract

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Abstract

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