Skip to main content
Top
Published in: International Journal of Legal Medicine 3/2018

01-05-2018 | Case Report

Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia

Authors: Fidel A. Acevedo, Esther J. Kim, David A. Chyatte, Vance G. Nielsen

Published in: International Journal of Legal Medicine | Issue 3/2018

Login to get access

Abstract

We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery. The patient presented with delirium and severe methemoglobinemia (41%) that responded to discontinuation of lidocaine therapy, oxygen administration, and methylene blue administration. The clinical contributors and medicolegal implications of this degree of lidocaine-associated methemoglobin-mediated delirium are presented in the hope of avoiding similar complications in the postoperative setting after coronary bypass surgery.
Literature
1.
go back to reference Browne SM, Halligan PW, Wade DT, Taggart DP (2003) Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery. J Thorac Cardiovasc Surg 126:1061–1064CrossRef Browne SM, Halligan PW, Wade DT, Taggart DP (2003) Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery. J Thorac Cardiovasc Surg 126:1061–1064CrossRef
2.
go back to reference Hartman N, Zhou H, Mao J, Mans D, Boyne M 2nd, Patel V, Colatsky T (2017) Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. Xenobiotica 47:431–438CrossRef Hartman N, Zhou H, Mao J, Mans D, Boyne M 2nd, Patel V, Colatsky T (2017) Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. Xenobiotica 47:431–438CrossRef
3.
go back to reference Weingarten TN, Gleich SJ, Craig JR, Sprung J (2012) Methemoglobinemia in the setting of chronic transdermal lidocaine patch use. Pain Med 13:976–977CrossRef Weingarten TN, Gleich SJ, Craig JR, Sprung J (2012) Methemoglobinemia in the setting of chronic transdermal lidocaine patch use. Pain Med 13:976–977CrossRef
4.
go back to reference Coleman MD, Coleman NA (1996) Drug induced methemoglobinemia. Treatment issues. Drug Saf 14:394–405CrossRef Coleman MD, Coleman NA (1996) Drug induced methemoglobinemia. Treatment issues. Drug Saf 14:394–405CrossRef
5.
go back to reference Wright RO, Lewander WJ, Woolf AD (1999) Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 34:646–656CrossRef Wright RO, Lewander WJ, Woolf AD (1999) Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 34:646–656CrossRef
6.
go back to reference Chowdhary S, Bukoye B, Bhansali AM, Carbo AR, Adra M, Barnett S, Aronson MD, Leffler DA (2013) Risk of topical anesthetic-induced methemoglobinemia: a 10-year retrospective case-control study. JAMA Intern Med 173:771–776CrossRef Chowdhary S, Bukoye B, Bhansali AM, Carbo AR, Adra M, Barnett S, Aronson MD, Leffler DA (2013) Risk of topical anesthetic-induced methemoglobinemia: a 10-year retrospective case-control study. JAMA Intern Med 173:771–776CrossRef
7.
go back to reference De Martin S, Orlando R, Bertoli M, Pegoraro P, Palatini P (2006) Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis. Clin Pharmacol Ther 80:597–606CrossRef De Martin S, Orlando R, Bertoli M, Pegoraro P, Palatini P (2006) Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis. Clin Pharmacol Ther 80:597–606CrossRef
9.
go back to reference Kanji HD, Mithani S, Boucher P, Dias VC, Yarema MC (2013) Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. J Popul Ther Clin Pharmacol 20:e207–e211PubMed Kanji HD, Mithani S, Boucher P, Dias VC, Yarema MC (2013) Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. J Popul Ther Clin Pharmacol 20:e207–e211PubMed
10.
go back to reference Rawlins MD, Henderson DB, Hijab AR (1977) Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 11:283–286CrossRef Rawlins MD, Henderson DB, Hijab AR (1977) Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 11:283–286CrossRef
11.
go back to reference Barker SJ, Tremper KK, Hyatt J (1989) Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry. Anesthesiology 70:112–117CrossRef Barker SJ, Tremper KK, Hyatt J (1989) Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry. Anesthesiology 70:112–117CrossRef
Metadata
Title
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia
Authors
Fidel A. Acevedo
Esther J. Kim
David A. Chyatte
Vance G. Nielsen
Publication date
01-05-2018
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Legal Medicine / Issue 3/2018
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI
https://doi.org/10.1007/s00414-017-1682-7

Other articles of this Issue 3/2018

International Journal of Legal Medicine 3/2018 Go to the issue