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01-05-2015 | Original Article

Visualization of myocardial infarction by post-mortem single-organ coronary computed tomography: a feasibility study

Authors: Matteo Polacco, Pietro Sedati, Vincenzo Arena, Vincenzo L. Pascali, Bruno Beomonte Zobel, Antonio Oliva, Riccardo Rossi

Published in: International Journal of Legal Medicine | Issue 3/2015

Abstract

Introduction

Post-mortem imaging is increasingly used in forensic field in cases of natural deaths related to cardiovascular diseases, which represent the most common causes of death in developed countries. While radiological examination is generally considered to be a good complement for conventional autopsy, it was thought to have limited application in cardiovascular pathology. The aim of this study was to investigate the role of post-mortem multidetector coronary artery computed tomography in cases of sudden death in adults.

Materials and methods

We have enrolled 11 cases, all of whom were negative for macroscopic extra-cardiac lethal findings after standard autopsy procedure. Later, from the same individuals, isolated single-organ post-mortem computed tomography coronarography (PMCTA), using an iodinated non-ionic contrast medium, was achieved. After computed tomography examination, all the isolated hearths were carried to the forensic pathologist, and a conventional histology assessment was performed on them.

Results

In 7 out of 11 of cadavers, a final diagnosis of myocardial infarction was made after a complete autopsy and histology procedures. Isolated hearts underwent PMCTA scanning and was confirmed in 6/11 cases, with the autopsy findings showing the presence and the localization of occlusions or severe stenoses and the extension of the myocardial hypoxic area by the extravasation of contrast medium as well.

Conclusion

Isolated single-organ PMCTA could be considered a valid and useful tool in addition to traditional autopsy investigation (macroscopic sections and histology) in identifying the cause of death by recognizing the presence and degree of coronary artery disease and myocardial infarction area visualization.

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Title: Visualization of myocardial infarction by post-mortem single-organ coronary computed tomography: a feasibility study
Authors: Matteo Polacco
Pietro Sedati
Vincenzo Arena
Vincenzo L. Pascali
Bruno Beomonte Zobel
Antonio Oliva
Riccardo Rossi
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 3/2015
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-014-1085-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Visualization of myocardial infarction by post-mortem single-organ coronary computed tomography: a feasibility study

Abstract

Introduction

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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