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01-11-2010 | ORIGINAL ARTICLE

Immunohistochemical expression of fibronectin in the lungs of fire victims proves intravital reaction in fatal burns

Authors: Michael Bohnert, Jürina Anderson, Markus A. Rothschild, Joachim Böhm

Published in: International Journal of Legal Medicine | Issue 6/2010

Abstract

Immunohistochemical studies about the presence of fibronectin in the lungs were performed in a group of 73 fire victims (63 cases of intravital and 10 cases of postmortem burn) as well as in an unselected control group of 55 individuals not exposed to fire before death. The cases of intravital burn showed a significantly stronger fibronectin expression than the control cases and the cases of postmortem burn. Fibronectin was mainly present in macrophages of the peribronchial lung parenchyma and, not associated with cells, in the matrix of peribronchial tissue. Our findings suggest that higher levels of fibronectin expression in the lung tissue of burn victims compared to fire-unrelated deaths may serve as an indicator of an early intravital inflammatory response to fire damage.

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Title: Immunohistochemical expression of fibronectin in the lungs of fire victims proves intravital reaction in fatal burns
Authors: Michael Bohnert
Jürina Anderson
Markus A. Rothschild
Joachim Böhm
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 6/2010
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-010-0437-5

At a glance: The STEP trials

Springer Medicine

Immunohistochemical expression of fibronectin in the lungs of fire victims proves intravital reaction in fatal burns

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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