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01-03-2010 | SHORT COMMUNICATION

The novel H1N1/swine-origin influenza virus and its implications for autopsy practice

Authors: Frank Ramsthaler, Marcel A. Verhoff, Axel Gehl, Mattias Kettner

Published in: International Journal of Legal Medicine | Issue 2/2010

Abstract

As fatalities attributable to novel H1N1/S-OIV infections are currently rising, an increasing number of autopsies will have to be performed on these cases. In view of this challenge, adequate safety precautions and recommendations for autopsy procedures and the sampling and handling of specimens have to be established. Based on current literature, procedures for daily autopsy practice are proposed, particularly in regard to personal protection equipment, swab usage, and autopsy hygiene.

Angus N (2009) Personal measures to reduce the risk of catching influenza or passing it on—the underlying public health science. ECDC Health Information. Avaiable via http://www.ecdc.europa.eu/en/healthtopics/documents/0905_influenza_ah1n1_personal_measures_to_reduce_the_risk_of_catching_influenza.pdf

Archer BN, Cohen C, Naidoo D et al (2009) Interim report on pandemic H1N1 influenza virus infections in South Africa, April to October 2009: epidemiology and factors associated with fatal cases. Euro Surveill 14:1–5

CDC (2009) Interim biosafety guidance for all individuals handling clinical specimens or isolates containing 2009-H1N1 influenza A virus (novel H1N1), including vaccine strains. Available via http://www.cdc.gov/h1n1flu/guidelines_labworkers.htm. Accessed 17 Nov 2009

CDC (2009) Post-mortem care and safe autopsy procedures for novel H1N1 influenza. Available via http://www.cdc.gov/h1n1flu/post_mortem.htm. Accessed 17 Nov 2009

CDC (2009c) Swine Influenza A (H1N1) Infection in two children—Southern California, March–April 2009. MMWR 58:400–402

Dreller S, Jatzwauk L, Nassauer A et al (2006) Zur Frage des geeigneten Atemschutzes vor luftübertragenen Infektionserregern. Gefahrstoffe-Reinhalt Luft 66:14–24

EPA (2009) Antimicrobial products registered for use against the H1N1 flu and other influenza A viruses on hard surfaces. Available via http://www.epa.gov/oppad001/influenza-disinfectants.html. Accessed 17 Nov 2009

EPA (2009) Guidance for testing and labeling claims against pandemic 2009 H1N1 Influenza A virus (formerly called swine flu). Available via http://www.epa.gov/oppad001/h1n1-guide.html. Accessed 11 Dec 2009

Faix DJ, Sherman SS, Waterman SH (2009) Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 361:728–729CrossRefPubMed

10.

Fisman DN, Savage R, Gubbay J et al (2009) Older age and a reduced likelihood of 2009 H1N1 virus infection. N Engl J Med 361:2000–2001CrossRefPubMed

11.

Ginocchio CC, Zhang F, Mani R et al (2009) Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak. J Clin Virol 45:191–195CrossRefPubMed

12.

Grayson ML, Melvani S, Druce J et al (2009) Efficacy of soap and water and alcohol-based hand-rub preparations against live H1N1 influenza virus on the hands of human volunteers. Clin Infect Dis 48:285–291CrossRefPubMed

13.

ECDC Interim Recommendations (2006) Personal (non-pharmaceutical) protective measures for reducing transmission of human influenza, October 2006. Available via http://ecdc.europa.eu/documents/pdf/PPHM_Recommendations.pdf

14.

Loeb M, Dafoe N, Mahony J et al (2009) Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA 302:1865–1871CrossRefPubMed

15.

Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, Finelli L et al (2009) Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 360:2605–2615CrossRefPubMed

16.

RKI (2007) Desinfektion - Liste der vom Robert Koch-Institut geprüften und anerkannten Desinfektionsmittel und –verfahren. Available via http://www.rki.de/cln_091/nn_206124/DE/Content/Infekt/Krankenhaushygiene/Desinfektionsmittel/desinfektionsmittel__node.html?__nnn=true. Accessed 17 Nov 2009

17.

RKI (2009) Empfehlung des Robert Koch-Institutes zu Hygienemaßnahmen bei Patienten mit Verdacht auf bzw. nachgewiesener Influenza. Available via http://www.rki.de/cln_091/nn_200120/DE/Content/Infekt/Krankenhaushygiene/Erreger__ausgewaehlt/Influenza/Influ__pdf.html. Accessed 11 Dec 2009

18.

RKI (2009) Epidemiologischer Wochenbericht des Robert Koch-Instituts zur Situation der Influenza A/H1N1. Available via http://www.rki.de/cln_100/nn_200120/DE/Content/InfAZ/I/Influenza/IPV/Epidemiologischer-Wochenbericht,templateId=raw,property=publicationFile.pdf/Epidemiologischer-Wochenbericht.pdf. Accessed 11 Dec 2009

19.

WHO (2009) CDC protocol of realtime RTPCR for influenza A(H1N1). Available via http://www.who.int/csr/resources/publications/swineflu/CDCRealtimeRTPCR_SwineH1Assay-2009_20090430.pdf. Accessed 18 Nov 2009

20.

Zimmer SM, Burke DS (2009) Historical perspective—emergence of influenza A (H1N1) viruses. N Engl J Med 361:279–285CrossRefPubMed

Title: The novel H1N1/swine-origin influenza virus and its implications for autopsy practice
Authors: Frank Ramsthaler
Marcel A. Verhoff
Axel Gehl
Mattias Kettner
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 2/2010
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-009-0405-0

At a glance: The STEP trials

Springer Medicine

The novel H1N1/swine-origin influenza virus and its implications for autopsy practice

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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