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01-02-2004 | Original Article

Genetic analysis of human remains found in two eighteenth century Yakut graves at At-Dabaan

Authors: François-Xavier Ricaut, Sergei Kolodesnikov, Christine Keyser-Tracqui, Anatoly Nikoyevich Alekseev, Eric Crubézy, Bertrand Ludes

Published in: International Journal of Legal Medicine | Issue 1/2004

Abstract

We extracted DNA from three skeletons belonging to the Yakut population, which were excavated from the At-Dabaan site (dating back 300 years) in the Sakha Republic (Russia). Ancient DNA was analyzed by autosomal STRs (short tandem repeats) and by the sequencing of the hypervariable region 1 (HV1) of the mitochondrial DNA (mtDNA) control region. The results showed that these three skeletons were not close relatives but probably linked to the same clan structure. Comparison of their haplotypes with the haplotypes of 8,774 Eurasian individuals suggested a relative specificity and continuity of part of the Yakut mitochondrial gene pool during the last 3 centuries.

Alekseev AN (1996) Ancient Yakutia: the Iron Age and the medieval epoch (in Russian). Izdatel’stvo Instituta Akheologii i Etnogrfii SO RAN, Novosibirsk

Anderson S, Bankier AT, Barrell BG et al. (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–465PubMed

Balzer MM (1994) Yakut. In: Friedrich P, Diamond N (eds) Encyclopedia of world culture, vol I. Russia and Eurasia/China. Hall, New York, pp 404–407

Betty DJ, Chin-Atkins AN, Croft L, Sraml M, Easteal S (1996) Multiple independent origins of the COII/tRNALys intergenic 9 bp mtDNA deletion in aboriginal Australians. Am J Hum Genet 58:428–433PubMed

Boeva SB (1988) Anthropogenetic study of the indigenous population of the Yakut ASSR in connection with the ethnogenesis of the Yakuts. PH.D. thesis (in Russian), Moscow State University, Moscow

Clisson I, Keyser C, Francfort HP, Crubézy E, Samashev Z, Ludes B (2002) Genetic analysis of human remains from a double inhumation in a frozen kurgan in Kazakhstan (Berel site, Early 3^rd Century BC). Int J Legal Med 116:304–308PubMed

Comas D, Calafell F, Mateu E et al. (1998) Trading genes along the silk road: mtDNA sequences and the origin of central populations. Am J Hum Genet 63:1824–1838PubMed

Derbeneva OA, Starikovskaya EB, Wallace DC, Subernik RI (2002) Traces of early Eurasians in the Mansi of northwest Siberia revealed by mitochondrial DNA analysis. Am J Hum Genet 70:1009–1014CrossRefPubMed

Derenko MV, Shields GF (1997) Mitochondrial DNA sequence diversity in three north Asian aboriginal populations groups. Mol Biol (Mosk) 31:665–669

Derenko MV, Malyarchuk BA, Dambueva IK, Shaikhaev GO, Dorzhu CM, Nimaev DD, Zakharov AIA (2000) Mitochondrial DNA variation in two south Siberian aboriginal populations: implications for the genetic history of north Asia. Hum Biol 72:945–973PubMed

Fefelova VV (1990) Participation of Indo-European tribes in ethnogeny of the Mongoloid population of Siberia. Am J Hum Genet 47:294–301PubMed

Fily ML, Crubézy E, Courtaud P, Keyser C, Ebrard D, Ludes B (1998) Paleogenetic analysis of the skeletons from the sepulchral cave of Elzarreko Karbia (Bronze Age, Basque Country). C R Acad Sci Paris 321:79–85PubMed

Fondahl G (1994) Evenki northern Tungus. In: Friedrich P, Diamond N (eds) Encyclopedia of world culture, vol VI-Russia and Eurasia/China. Hall, New York, pp 120–124

Forsyth J (1996) A history of the peoples of Siberia. Cambridge University Press, Cambridge

Gabriel MN, Huffine EF, Ryan JH, Holland MM, Parsons TJ (2001) Improved mtDNA sequence analysis of forensic remains using “mini-primer set” amplification strategy. J Forensic Sci 46:247–253PubMed

Handt O, Höss M, Krings M, Pääbo S (1994) Ancient DNA: methodological challenge. Experientia 50:524–529PubMed

Horai S, Murayama K, Hayasaka K et al. (1996) MtDNA polymorphism in east Asian populations, with special reference to the peopling of Japan. Am J Hum Genet 59:579–590PubMed

Hummel S, Bramanti B, Schultes T, Kahle M, Haffner S, Herrmann B (2000) Megaplex DNA typing can provide a strong indication of the authenticity of ancient DNA amplifications by clearly recognizing any possible modern contamination. Anthropol Anz 58:15–21PubMed

Imaizumi K, Parsons TJ, Yoshino M, Holland MM (2002) A new database of mitochondrial DNA hypervariable regions I and II sequence from 162 Japanese individuals. Int J Legal Med 116:68–73PubMed

Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408:708–713PubMed

Ivanov PL, Wadhams MJ, Holland MM, Weedn VW, Parsons TJ (1996) Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II. Nat Genet 12:417–420PubMed

Jehaes E, Toprak K, Vanderheyden N, Pfeiffer H, Cassiman JJ, Brinkmann B, Decorte R (2001) Pitfalls in the analysis of mitochondrial DNA from ancient specimens and the consequences for forensic DNA analysis: the historical case of the putative heart of Louis XVII. Int J Legal Med 115:135–141PubMed

Keyser-Tracqui C, Crubézy E, Ludes B (2003) Nuclear and mitochondrial analysis of a 2000-year-old necropolis in the Egyin Gol valley (Mongolia). Am J Hum Genet 73:247–260CrossRefPubMed

Kivisild T, Bamshad MJ, Kaldma K et al. (1999) Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages. Curr Biol 9:1331–1334PubMed

Kolman CJ, Sambuughin N, Bermingham E (1996) Mitochondrial DNA analysis of Mongolian populations and implications for the origin of new world founders. Genetics 142:1321–1334PubMed

Kolodesnikov S (2000) The person in traditional Yakut (Sakha) worldview. Archaeol Ethnol Anthropol Eurasia 39:42–79

Lee SD, Shin CH, Kim KB, Lee YS, Lee JB (1997) Sequence variation of mitochondrial region DNA control region in Koreans. Forensic Sci Int 87:99–116PubMed

Leonard JA, Wayne RK, Cooper A (2000) Population genetics of Ice Age brown bears. Proc Natl Acad Sci U S A 97:1651–1654CrossRefPubMed

Levin MG, Potatov LP (1964) The peoples of Siberia. Chicago University Press, Chicago

Macaulay V, Richards M, Hickey E et al. (1999) The emerging tree of west Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. Am J Hum Genet 64:232–249PubMed

Meinila M, Finnila S, Majamaa K (2001) Evidence for mtDNA admixture between the Finns and the Saami. Hum Hered 52:160–170PubMed

Miller CR, Joyce P, Waits LP (2002) Assessing allelic dropout and genotype reliability using maximum likelihood. Genetics 160:357–366PubMed

Mountain JL, Hebert JM, Bhattacharyya S, Underhill PA, Ottolenghi C, Gadgil M, Cavalli-Sforza L (1995) Demographic history of India and mtDNA-sequence diversity. Am J Hum Genet 56:979–992PubMed

Nishimaki Y, Sato K, Fang L, Ma M, Hasekura H, Boettcher B (1999) Sequence polymorphism in the mtDNA HV1 region in Japanese and Chinese. Legal Med 1:238–249CrossRef

Oota H, Kitano T, Jin F et al. (2002) Extreme mtDNA homogeneity in continental Asian populations. Am J Hum Genet 118:146–153CrossRef

Orekhov V, Poltoraus A, Zhivotovsky LA, Spitsyn V, Ivanov P, Yankovsky N (1999) Mitochondrial DNA sequence diversity in Russians. FEBS Lett 445:197–201CrossRefPubMed

O’Rourke DH, Hayes MG, Carlyle W (2000) Ancient DNA studies in physical anthropology. Annu Rev Anthropol 29:217–242CrossRef

Pakendorf B, Spitsyn VA, Rodewald A (1999) Genetic structure of a Sakha population from Siberia and ethnic affinities. Hum Biol 71:231–244PubMed

Pakendorf B, Morar B, Tarskaia LA, Kayser M, Soodyall H, Rodewald A, Stoneking M (2002) Y-chromosome evidence for a strong reduction in male population size of Yakuts. Hum Genet 110:198–200CrossRefPubMed

Pakendorf B, Wiebe V, Tarskaia LA, Spitsyn VA, Soodyall H, Rodewald A, Stoneking M (2003) Mitochondrial DNA evidence for admixed origins of central Siberian populations. Am J Phys Anthropol 120:211–224CrossRefPubMed

Parson W, Parsons TJ, Scheithauer R, Holland MM (1998) Population data for 101 Austrian Caucasian mitochondrial DNA d-loop sequences: application of mtDNA sequence analysis to a forensic case. Int J Legal Med 111:124–132PubMed

Ricaut FX, Keyser-Tracqui C, Cammaert L, Crubézy E, Ludes B (2003) Genetic analysis and ethnic affinities from two Scytho-Siberian skeletons. Am J Phys Anthropol (in press)

Richards M, Corte-Real H, Forster P et al. (1996) Palaeolithic and neolithic lineages in the European mitochondrial gene pool. Am J Hum Genet 59:604–615

Richards M, Macauley V, Hickey V et al. (2000) Tracing European founder lineages in the near eastern mtDNA pool. Am J Hum Genet 67:1251–1276PubMed

Roux JP (1963) La mort chez les peuples altaïques anciens et médiévaux. Librairie d’Amérique et d’Orient Adrien-Maisonneuve, Paris

Sajantila A, Lahermo P, Anttinen T et al. (1995) Genes and languages in Europe: an analysis of mitochondrial lineages. Genome Res 5:42–52PubMed

Sajantila A, Salem AH, Savolainen P, Bauer K, Gierig C, Pääbo S (1996) Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population. Proc Natl Acad Sci U S A 93:12035–12039CrossRefPubMed

Santos FR, Pandya A, Tyler-Smith C et al. (1999) The central Siberian origin for Native American Y chromosome. Am J Hum Genet 64:619–628PubMed

Schmerer WM, Hummel S, Herrmann B (1999) Optimized DNA extraction to improve reproducibility of short tandem repeat genotyping with highly degraded DNA target. Electrophoresis 20:1712–1716CrossRefPubMed

Schurr TG, Subernik RI, Starikovskaya YB, Wallace DC (1999) Mitochondrial DNA variation in koryaks and itel’men: population replacement in the Okhotsk sea-Bering sea region during the neolithic. Am J Phys Anthropol 108:1–39CrossRefPubMed

Shields GF, Schmiechen AM, Frazier BL, Redd A, Voevoda MI, Reed JK, Ward RH (1993) mtDNA sequences suggest a recent evolutionary divergence for Beringian and northern north America populations. Am J Hum Genet 53:549–562PubMed

Snall N, Savontaus ML, Kares S, Lee MS, Cho EK, Rinne JO, Huoponen AK (2002) A rare mitochondrial DNA haplotype observed in Koreans. Hum Biol 74:253–262PubMed

Starikovskaya YB, Subernik RI, Schurr TG, Kogelnik AM, Wallace DC (1998) MtDNA diversity in Chukchi and Siberian Eskimos: implications for the genetic history of ancient Beringia and the peopling of the New World. Am J Hum Genet 63:1473–1491PubMed

Szibor R, Michael M (1999) Correct mitochondrial L-strand sequencing after C-stretches. Int J Legal Med 112:348–349CrossRefPubMed

Torroni A, Schurr TG, Cabell MF et al. (1993a) Asian affinities and continental radiation of the four founding native American mtDNAs. Am J Hum Genet 53:563–590PubMed

Torroni A, Subernik RI, Schurr TG et al. (1993b) MtDNA variation of aboriginal Siberians reveals distinct genetic affinities with native Americans. Am J Hum Genet 53:591–608PubMed

Tsai LC, Lin CY, Chang JG, Linacre A, Goodwin W (2001) Sequence polymorphism of mitochondrial D-Loop DNA in the Taiwanese Han population. Forensic Sci Int 119:239–247CrossRefPubMed

Voevoda MI, Avksentyuk AV, Ivanova AV et al. (1994) Molecular genetic study in a population of indigenous Chukotka inhabitants: an analysis of mitochondrial DNA polymorphism and genes of alcohol-metabolizing enzymes (in Russian).Sib Ecol Zhurnal 2:149–162

Voevoda MI, Romashchenko AG, Sitnikova VV, Shulgina EO, Kobsev VF (2000) a comparison of mitochondrial DNA polymorphism in Pazyrik and modern Eurasian populations. Archaeol Ethnol Anthropol Eurasia 4:88–94

Yao YG, Lu XM, Luo HR, Li WH, Zhang YP (2000) Gene admixture in the silk road region of China: evidence from mtDNA and melanocortin1 receptor polymorphism. Genes Genet Syst 75:173–178CrossRefPubMed

Yao YG, Kong QP, Bandelt HJ, Kivisild T, Zhang YP (2002a) Phylogeographic differentiation of mitochondrial DNA in Han Chinese. Am J Hum Genet 70:635–651

Yao YG, Nie L, Harpending H, Fu YX, Yuan ZG, Zhang YP (2002b) Genetic relationship of Chinese ethnic populations revealed by mtDNA sequence diversity. Am J Phys Anthropol 118:63–76CrossRefPubMed

Title: Genetic analysis of human remains found in two eighteenth century Yakut graves at At-Dabaan
Authors: François-Xavier Ricaut
Sergei Kolodesnikov
Christine Keyser-Tracqui
Anatoly Nikoyevich Alekseev
Eric Crubézy
Bertrand Ludes
Publication date: 01-02-2004
Publisher: Springer-Verlag
Published in: International Journal of Legal Medicine / Issue 1/2004
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-003-0411-6

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Genetic analysis of human remains found in two eighteenth century Yakut graves at At-Dabaan

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