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European Archives of Psychiatry and Clinical Neuroscience

Published in:

01-04-2019 | Original Paper

Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder

Authors: Ahmet Zihni Soyata, Serkan Aksu, Adam J. Woods, Pınar İşçen, Kardelen Türkü Saçar, Sacit Karamürsel

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2019

Abstract

Decision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder. Twenty participants with gambling disorder were administered Iowa Gambling Task (IGT) and Wisconsin Card Sorting Test (WCST). Subsequently, participants were administered three every other day sessions of active right anodal /left cathodal tDCS (20 min, 2 mA) or sham stimulation over bilateral DLPFC. WCST and IGT were readministered following the last session. Baseline clinical severity, depression, impulsivity levels, and cognitive performance were similar between groups. TDCS over the DLPFC resulted in more advantageous decision making (F_1,16 = 8.128, p = 0.01, ɳp² =0.33) and better cognitive flexibility (F_1,16 =8.782, p = 0.009, ɳp² = 0.35), representing large effect sizes. The results suggest for the first time that tDCS enhanced decision making and cognitive flexibility in gambling disorder. Therefore, tDCS may be a promising neuromodulation-based therapeutic approach in gambling disorder.

Trial registration: Clinicaltrials.gov NCT03477799.

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Title: Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder
Authors: Ahmet Zihni Soyata
Serkan Aksu
Adam J. Woods
Pınar İşçen
Kardelen Türkü Saçar
Sacit Karamürsel
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2019
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0948-5

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Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder

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