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European Archives of Psychiatry and Clinical Neuroscience

Published in:

01-10-2019 | Original Paper

Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort

Authors: Caroline Hurault-Delarue, Isabelle Lacroix, Anne Bénard-Laribière, Jean-Louis Montastruc, Antoine Pariente, Christine Damase-Michel

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 7/2019

Abstract

Background

Previous studies have suggested that exposure to some antidepressants (AD) during pregnancy could be associated with an increased risk of congenital malformations and neurodevelopment disorders for the child. We conducted a study to describe the use of AD during pregnancy in France.

Methods

We performed a drug utilisation study in EFEMERIS, a French cohort of pregnant women. At the time of the present study, 89,170 pregnant women, who were pregnant from 2005 to 2014 in Haute-Garonne were included. Prevalence and incidence of AD prescriptions during pregnancy, characteristics of AD users, and trends in AD use over the 10-year period were studied.

Results

During the 10-year study period, 1620 women registered in EFEMERIS (1.8%) received at least one prescription and dispensation for AD during pregnancy: 1363 during the first (1.5%), 591 during the second (0.7%), and 412 during the third (0.5%) trimester. A total of 2874 women (3.2%) got a prescription for an AD during the 3 months before and/or during pregnancy; 2187 of them (76.1%) stopped AD before pregnancy or during the first trimester. Selective serotonin reuptake inhibitors represented the most prescribed class during pregnancy (1.3%). A very slight decrease in the prevalence of AD prescriptions in pregnant women over time (1.7% in 2014 vs 2% in 2005) and some variations within classes were observed.

Conclusions

Nearly, 2% of women received antidepressant drugs during pregnancy. This assessment encourages following research on these drugs including the potential risk of neurodevelopmental disorders in children after an exposure to antidepressants during pregnancy.

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Title: Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort
Authors: Caroline Hurault-Delarue
Isabelle Lacroix
Anne Bénard-Laribière
Jean-Louis Montastruc
Antoine Pariente
Christine Damase-Michel
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 7/2019
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0906-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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