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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 1/2018

01-02-2018 | Invited Review

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

Authors: S. Kanji, T. M. Fonseka, V. S. Marshe, V. Sriretnakumar, M. K. Hahn, D. J. Müller

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 1/2018

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Abstract

With the emergence of knowledge implicating the human gut microbiome in the development and regulation of several physiological systems, evidence has accumulated to suggest a role for the gut microbiome in psychiatric conditions and drug response. A complex relationship between the enteric nervous system, the gut microbiota and the central nervous system has been described which allows for the microbiota to influence and respond to a variety of behaviors and psychiatric conditions. Additionally, the use of pharmaceuticals may interact with and alter the microbiota to potentially contribute to adverse effects of the drug. The gut microbiota has been described in several psychiatric disorders including depression and anxiety, but only a few reports have discussed the role of the microbiome in schizophrenia. The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiota and promote adverse metabolic events.
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Metadata
Title
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain
Authors
S. Kanji
T. M. Fonseka
V. S. Marshe
V. Sriretnakumar
M. K. Hahn
D. J. Müller
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 1/2018
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-017-0820-z

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