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European Archives of Psychiatry and Clinical Neuroscience

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01-02-2017 | Editorial

Candidate gene associations studies in psychiatry: time to move forward

Author: C. Arango

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 1/2017

Excerpt

In the present issue, de Castro-Sala et al. report an association between two single-nucleotide polymorphisms in the regulator of G-protein signalling 4 (RGS4) gene, a candidate gene for schizophrenia and psychotic-like experiences, in 808 healthy individuals [1]. Recent papers in this journal have focused on the genetic association between polymorphisms in candidate genes and risk behaviour [2] or associations between polymorphisms of the dopamine transporter and gene personality traits in patients with bipolar disorder [3]. None of these were published with replications in independent cohorts. …

De Castro-Sala M, Cristóbal-Narváez P, Kwapil TR et al (2016) Association between RGS4 variants and psychotic-like experiences in nonclinical individuals. Eur Arch Psychiatry Clin Neurosci. doi:10.1007/s00406-016-0676-7

Antypa N, Souery D, Tomasini M et al (2016) Clinical and genetic factors associated with suicide in mood disorder patients. Eur Arch Psychiatry Clin Neurosci 266:181–193CrossRefPubMed

Huang CC, Lu RB, Yen CH et al (2015) Dopamine transporter gene may be associated with bipolar disorder and its personality traits. Eur Arch Psychiatry Clin Neurosci 265:281–290CrossRefPubMed

Farrell MS, Werge T, Sklar P, Owen MJ et al (2015) Evaluating historical candidate genes for schizophrenia. Mol Psychiatry 20:555–562CrossRefPubMedPubMedCentral

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Geschwind DH, State MW (2015) Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurol 14:1109–1120CrossRefPubMedPubMedCentral

Fraguas D, Díaz-Caneja CM, State MW et al (2016) Mental disorders of known aetiology and precision medicine in psychiatry: a promising but neglected alliance. Psychol Med 23:1–5

Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH (2016) The road to precision psychiatry: translating genetics into disease mechanisms. Nat Neurosci 19:1397–1407CrossRefPubMed

Title: Candidate gene associations studies in psychiatry: time to move forward
Author: C. Arango
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 1/2017
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-016-0765-7

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