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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 1/2016

01-02-2016 | Original Paper

Bilaterally reduced claustral volumes in schizophrenia and major depressive disorder: a morphometric postmortem study

Authors: Hans-Gert Bernstein, Anna Ortmann, Henrik Dobrowolny, Johann Steiner, Ralf Brisch, Tomasz Gos, Bernhard Bogerts

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 1/2016

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Abstract

Multiple brain structural abnormalities have been reported in schizophrenia and major depressive disorder. A majority of disease-affected brain regions act as relay nodes within neural networks, which are known to be impaired in neuropsychiatric diseases. One of these regions is the claustrum, which has the highest connectivity in the human brain by regional volume. Its possible involvement in disturbed connectivity is yet incompletely explored, however. The present study aimed at searching for possible structural deviations of the claustrum in neuropsychiatric disorders. We found bilaterally reduced claustral volumes both in schizophrenia and in major depressive disorder. These structural impairments may have different, disease-related consequences: In patients with schizophrenia, they may contribute to sensory processing impairments, and in patients with major depressive disorder to disturbances in salience.
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Metadata
Title
Bilaterally reduced claustral volumes in schizophrenia and major depressive disorder: a morphometric postmortem study
Authors
Hans-Gert Bernstein
Anna Ortmann
Henrik Dobrowolny
Johann Steiner
Ralf Brisch
Tomasz Gos
Bernhard Bogerts
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 1/2016
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-015-0597-x

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