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Published in: European Archives of Psychiatry and Clinical Neuroscience 1/2014

01-11-2014 | Review

Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis

Authors: Hendrik Müller, Sonja Laier, Andreas Bechdolf

Published in: European Archives of Psychiatry and Clinical Neuroscience | Special Issue 1/2014

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Abstract

The aim of psychotherapy among individuals at clinical high risk (CHR) for psychosis is to prevent transition to full-blown psychosis. Psychotherapy in individuals with a first-episode psychosis (FEP) aims to reduce relapse rates. Remission of (pre-) psychotic symptoms, psychosocial functioning, quality of life, comorbid disorders and self-esteem are also important outcomes in individuals at CHR and with FEP. Antipsychotics, Qmega-3-Fatty acids and psychotherapy have been found to be effective in CHR for most of these aims. Thereby psychotherapy presents a better benefit/risk ratio than antipsychotic medication. The most evidence-based intervention is cognitive-behavioral therapy (CBT). Psychotherapy is mostly offered to FEP patients within specialized early intervention services (including assertiveness community treatment and antipsychotic medication). Thereby, CBT is effective for positive symptoms and family intervention is particularly effective for the prevention of relapses. We introduce the principles of CBT for psychosis and suggest adaptions for individuals at CHR and FEP. We conclude that the needs of young people at CHR and with FEP are best met by specially designed, low threshold outpatient clinical services, which include intensive psychotherapy treatment. A number of countries have implemented early detection and intervention services based on this model, while the implementation within in Germany is still marginal.
Literature
1.
go back to reference Whiteford HA, Degenhardt L, Rehm J et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382:1575–1586PubMedCrossRef Whiteford HA, Degenhardt L, Rehm J et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382:1575–1586PubMedCrossRef
2.
go back to reference Konnopka A, Klingberg S, Wittorf A et al (2009) [The cost of schizophrenia in Germany: a systematic review of the literature]. Psychiatr Prax 36:211–218PubMedCrossRef Konnopka A, Klingberg S, Wittorf A et al (2009) [The cost of schizophrenia in Germany: a systematic review of the literature]. Psychiatr Prax 36:211–218PubMedCrossRef
4.
go back to reference Adams EK, Breen N, Joski PJ (2007) Impact of the National Breast and Cervical Cancer Early Detection Program on mammography and Pap test utilization among white, Hispanic, and African American women: 1996–2000. Cancer 109:348–358PubMedCrossRef Adams EK, Breen N, Joski PJ (2007) Impact of the National Breast and Cervical Cancer Early Detection Program on mammography and Pap test utilization among white, Hispanic, and African American women: 1996–2000. Cancer 109:348–358PubMedCrossRef
5.
go back to reference Peters AL, Davidson MB, Schriger DL et al (1996) A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the diagnosis of diabetes using glycated hemoglobin levels. J Am Med Assoc 276:1246–1252CrossRef Peters AL, Davidson MB, Schriger DL et al (1996) A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the diagnosis of diabetes using glycated hemoglobin levels. J Am Med Assoc 276:1246–1252CrossRef
6.
go back to reference Psaty BM, Lumley T, Furberg CD et al (2003) Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. J Am Med Assoc 289:2534–2544CrossRef Psaty BM, Lumley T, Furberg CD et al (2003) Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. J Am Med Assoc 289:2534–2544CrossRef
7.
go back to reference Häfner H, Riecher-Rossler A, Maurer K et al (1992) First onset and early symptomatology of schizophrenia. A chapter of epidemiological and neurobiological research into age and sex differences. Eur Arch Psychiatry Clin Neurosci 242:109–118PubMedCrossRef Häfner H, Riecher-Rossler A, Maurer K et al (1992) First onset and early symptomatology of schizophrenia. A chapter of epidemiological and neurobiological research into age and sex differences. Eur Arch Psychiatry Clin Neurosci 242:109–118PubMedCrossRef
8.
go back to reference Häfner H, Maurer K, An der Heiden W (2013) ABC Schizophrenia study: an overview of results since 1996. Soc Psychiatry Psychiatr Epidemiol 48:1021–1031PubMedCrossRef Häfner H, Maurer K, An der Heiden W (2013) ABC Schizophrenia study: an overview of results since 1996. Soc Psychiatry Psychiatr Epidemiol 48:1021–1031PubMedCrossRef
9.
go back to reference Fusar-Poli P, Borgwardt S, Bechdolf A et al (2013) the psychosis high-risk state a comprehensive state-of-the-art review psychosis high-risk state. JAMA Psychiatry 70:107–120PubMedCrossRef Fusar-Poli P, Borgwardt S, Bechdolf A et al (2013) the psychosis high-risk state a comprehensive state-of-the-art review psychosis high-risk state. JAMA Psychiatry 70:107–120PubMedCrossRef
10.
go back to reference Marshall M, Lewis S, Lockwood A et al (2005) Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 62:975–983PubMedCrossRef Marshall M, Lewis S, Lockwood A et al (2005) Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 62:975–983PubMedCrossRef
12.
go back to reference Schultze-Lutter F, Ruhrmann S, Fusar-Poli P et al (2012) Basic symptoms and the prediction of first-episode psychosis. Curr Pharm Des 18:351–357PubMedCrossRef Schultze-Lutter F, Ruhrmann S, Fusar-Poli P et al (2012) Basic symptoms and the prediction of first-episode psychosis. Curr Pharm Des 18:351–357PubMedCrossRef
13.
go back to reference Yung AR, Phillips LJ, Yuen HP et al (2003) Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 60:21–32PubMedCrossRef Yung AR, Phillips LJ, Yuen HP et al (2003) Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 60:21–32PubMedCrossRef
14.
go back to reference Broome MR, Woolley JB, Johns LC et al (2005) Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state. Eur Psychiatry 20:372–378PubMedCrossRef Broome MR, Woolley JB, Johns LC et al (2005) Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state. Eur Psychiatry 20:372–378PubMedCrossRef
15.
go back to reference Carr V, Halpin S, Lau N et al (2000) A risk factor screening and assessment protocol for schizophrenia and related psychosis. Aust N Z J Psychiatry 34(Suppl):S170–S180PubMedCrossRef Carr V, Halpin S, Lau N et al (2000) A risk factor screening and assessment protocol for schizophrenia and related psychosis. Aust N Z J Psychiatry 34(Suppl):S170–S180PubMedCrossRef
16.
go back to reference Cornblatt BA, Lencz T, Smith CW et al (2003) The schizophrenia prodrome revisited: a neurodevelopmental perspective. Schizophr Bull 29:633–651PubMedCrossRef Cornblatt BA, Lencz T, Smith CW et al (2003) The schizophrenia prodrome revisited: a neurodevelopmental perspective. Schizophr Bull 29:633–651PubMedCrossRef
17.
go back to reference McGlashan TH, Zipursky RB, Perkins D et al (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163:790–799PubMedCrossRef McGlashan TH, Zipursky RB, Perkins D et al (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163:790–799PubMedCrossRef
18.
go back to reference Ruhrmann S, Schultze-Lutter F, Salokangas RK et al (2010) Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry 67:241–251PubMedCrossRef Ruhrmann S, Schultze-Lutter F, Salokangas RK et al (2010) Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry 67:241–251PubMedCrossRef
19.
go back to reference Simon AE, Dvorsky DN, Boesch J et al (2006) Defining subjects at risk for psychosis: a comparison of two approaches. Schizophr Res 81:83–90PubMedCrossRef Simon AE, Dvorsky DN, Boesch J et al (2006) Defining subjects at risk for psychosis: a comparison of two approaches. Schizophr Res 81:83–90PubMedCrossRef
20.
go back to reference Yung AR, Stanford C, Cosgrave E et al (2006) Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophr Res 84:57–66PubMedCrossRef Yung AR, Stanford C, Cosgrave E et al (2006) Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophr Res 84:57–66PubMedCrossRef
21.
22.
go back to reference Klosterkotter J, Hellmich M, Steinmeyer EM et al (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164PubMedCrossRef Klosterkotter J, Hellmich M, Steinmeyer EM et al (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164PubMedCrossRef
24.
go back to reference Fusar-Poli P, Nelson B, Valmaggia L et al (2014) Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophr Bull 40:120–131PubMedCrossRefPubMedCentral Fusar-Poli P, Nelson B, Valmaggia L et al (2014) Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophr Bull 40:120–131PubMedCrossRefPubMedCentral
25.
26.
go back to reference Bechdolf A, Pukrop R, Kohn D et al (2005) Subjective quality of life in subjects at risk for a first episode of psychosis: a comparison with first episode schizophrenia patients and healthy controls. Schizophr Res 79:137–143PubMedCrossRef Bechdolf A, Pukrop R, Kohn D et al (2005) Subjective quality of life in subjects at risk for a first episode of psychosis: a comparison with first episode schizophrenia patients and healthy controls. Schizophr Res 79:137–143PubMedCrossRef
27.
go back to reference Lencz T, Smith CW, Auther A et al (2004) Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophr Res 68:37–48PubMedCrossRef Lencz T, Smith CW, Auther A et al (2004) Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophr Res 68:37–48PubMedCrossRef
28.
go back to reference Velthorst E, Nieman DH, Linszen D et al (2010) Disability in people clinically at high risk of psychosis. Br J Psychiatry 197:278–284PubMedCrossRef Velthorst E, Nieman DH, Linszen D et al (2010) Disability in people clinically at high risk of psychosis. Br J Psychiatry 197:278–284PubMedCrossRef
29.
30.
go back to reference Ziermans TB, Schothorst PF, Sprong M et al (2011) Transition and remission in adolescents at ultra-high risk for psychosis. Schizophr Res 126:58–64PubMedCrossRef Ziermans TB, Schothorst PF, Sprong M et al (2011) Transition and remission in adolescents at ultra-high risk for psychosis. Schizophr Res 126:58–64PubMedCrossRef
31.
go back to reference Fusar-Poli P, Deste G, Smieskova R et al (2012) Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry 69:562–571PubMed Fusar-Poli P, Deste G, Smieskova R et al (2012) Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry 69:562–571PubMed
32.
go back to reference Giuliano JA, Li H, Mesholam-Gately IR et al (2012) Neurocognition in the psychosis risk syndrome: a quantitative and qualitative review. Curr Pharm Des 18:399–415PubMedCrossRef Giuliano JA, Li H, Mesholam-Gately IR et al (2012) Neurocognition in the psychosis risk syndrome: a quantitative and qualitative review. Curr Pharm Des 18:399–415PubMedCrossRef
33.
go back to reference Phillips LJ, Velakoulis D, Pantelis C et al (2002) Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res 58:145–158PubMedCrossRef Phillips LJ, Velakoulis D, Pantelis C et al (2002) Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res 58:145–158PubMedCrossRef
34.
go back to reference Velakoulis D, Wood SJ, Wong MT et al (2006) Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 63:139–149PubMedCrossRef Velakoulis D, Wood SJ, Wong MT et al (2006) Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 63:139–149PubMedCrossRef
35.
go back to reference Yücel M, Wood SJ, Phillips LJ et al (2003) Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness. Br J Psychiatry 182:518–524PubMedCrossRef Yücel M, Wood SJ, Phillips LJ et al (2003) Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness. Br J Psychiatry 182:518–524PubMedCrossRef
36.
go back to reference Stone JM, Day F, Tsagaraki H et al (2009) Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Biol Psychiatry 66:533–539PubMedCrossRef Stone JM, Day F, Tsagaraki H et al (2009) Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Biol Psychiatry 66:533–539PubMedCrossRef
37.
go back to reference Fusar-Poli P, Howes O, Allen P et al (2009) Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Mol Psychiatry 16:67–75PubMedCrossRef Fusar-Poli P, Howes O, Allen P et al (2009) Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Mol Psychiatry 16:67–75PubMedCrossRef
38.
go back to reference Fusar-Poli P, Howes OD, Allen P et al (2010) Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Arch Gen Psychiatry 67:683–691PubMedCrossRef Fusar-Poli P, Howes OD, Allen P et al (2010) Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Arch Gen Psychiatry 67:683–691PubMedCrossRef
39.
go back to reference Fusar-Poli P, Stone JM, Broome MR et al (2011) Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis. Arch Gen Psychiatry 68:881–890PubMedCrossRef Fusar-Poli P, Stone JM, Broome MR et al (2011) Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis. Arch Gen Psychiatry 68:881–890PubMedCrossRef
40.
go back to reference McGlashan TH, Zipursky RB, Perkins D et al (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163:790–799PubMedCrossRef McGlashan TH, Zipursky RB, Perkins D et al (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163:790–799PubMedCrossRef
41.
go back to reference McGorry P, Nelson B, Phillips L et al (2012) Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome. J Clin Psychiatry. doi:10.4088/JCP.12m07785 McGorry P, Nelson B, Phillips L et al (2012) Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome. J Clin Psychiatry. doi:10.​4088/​JCP.​12m07785
42.
go back to reference McGorry PD, Yung AR, Phillips LJ et al (2002) Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 59:921–928PubMedCrossRef McGorry PD, Yung AR, Phillips LJ et al (2002) Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 59:921–928PubMedCrossRef
43.
go back to reference Amminger GP, Schafer MR, Papageorgiou K et al (2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67:146–154PubMedCrossRef Amminger GP, Schafer MR, Papageorgiou K et al (2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67:146–154PubMedCrossRef
44.
go back to reference Addington J, Epstein I, Liu L et al (2011) A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis. Schizophr Res 125:54–61PubMedCrossRef Addington J, Epstein I, Liu L et al (2011) A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis. Schizophr Res 125:54–61PubMedCrossRef
45.
go back to reference Morrison AP, French P, Stewart SL et al (2012) Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial. BMJ 344:e2233PubMedCrossRefPubMedCentral Morrison AP, French P, Stewart SL et al (2012) Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial. BMJ 344:e2233PubMedCrossRefPubMedCentral
46.
go back to reference Morrison AP, French P, Walford L et al (2004) Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry 185:291–297PubMedCrossRef Morrison AP, French P, Walford L et al (2004) Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry 185:291–297PubMedCrossRef
47.
go back to reference van der Gaag M, Nieman DH, Rietdijk J et al (2012) Cognitive behavioral therapy for subjects at ultrahigh risk for developing psychosis: a randomized controlled clinical trial. Schizophr Bull 38:1180–1188CrossRefPubMedCentral van der Gaag M, Nieman DH, Rietdijk J et al (2012) Cognitive behavioral therapy for subjects at ultrahigh risk for developing psychosis: a randomized controlled clinical trial. Schizophr Bull 38:1180–1188CrossRefPubMedCentral
48.
go back to reference Bechdolf A, Wagner M, Ruhrmann S et al (2012) Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry 200:22–29PubMedCrossRef Bechdolf A, Wagner M, Ruhrmann S et al (2012) Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry 200:22–29PubMedCrossRef
49.
go back to reference Nordentoft M, Thorup A, Petersen L et al (2006) Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment. Schizophr Res 83:29–40PubMedCrossRef Nordentoft M, Thorup A, Petersen L et al (2006) Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment. Schizophr Res 83:29–40PubMedCrossRef
50.
go back to reference Miklowitz DJ, O’Brien MP, Schlosser DA et al (2014) Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial. J Am Acad Child Adolesc Psychiatry. doi:10.1016/j.jaac.2014.04.020 Miklowitz DJ, O’Brien MP, Schlosser DA et al (2014) Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial. J Am Acad Child Adolesc Psychiatry. doi:10.​1016/​j.​jaac.​2014.​04.​020
52.
go back to reference van der Gaag M, Smit F, Bechdolf A et al (2013) Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups. Schizophr Res 149:56–62PubMedCrossRef van der Gaag M, Smit F, Bechdolf A et al (2013) Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups. Schizophr Res 149:56–62PubMedCrossRef
53.
go back to reference Yusuf S, Sleight P, Pogue J et al (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 342:145–153PubMedCrossRef Yusuf S, Sleight P, Pogue J et al (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 342:145–153PubMedCrossRef
54.
go back to reference Angermeyer MC, Matschinger H, Schomerus G (2013) Attitudes towards psychiatric treatment and people with mental illness: changes over two decades. Br J Psychiatry 203:146–151PubMedCrossRef Angermeyer MC, Matschinger H, Schomerus G (2013) Attitudes towards psychiatric treatment and people with mental illness: changes over two decades. Br J Psychiatry 203:146–151PubMedCrossRef
55.
go back to reference Lauber C, Nordt C, Falcato L et al (2001) Lay recommendations on how to treat mental disorders. Soc Psychiatry Psychiatr Epidemiol 36:553–556PubMedCrossRef Lauber C, Nordt C, Falcato L et al (2001) Lay recommendations on how to treat mental disorders. Soc Psychiatry Psychiatr Epidemiol 36:553–556PubMedCrossRef
56.
go back to reference Morrison AP, Birchwood M, Pyle M et al (2013) Impact of cognitive therapy on internalised stigma in people with at-risk mental states. Br J Psychiatry 203:140–145PubMedCrossRef Morrison AP, Birchwood M, Pyle M et al (2013) Impact of cognitive therapy on internalised stigma in people with at-risk mental states. Br J Psychiatry 203:140–145PubMedCrossRef
57.
go back to reference Association AP (2006) American Psychiatric Association Practice Guidelines for the treatment of psychiatric disorders: compendium 2006. Am Psychiatric Pub, Washington Association AP (2006) American Psychiatric Association Practice Guidelines for the treatment of psychiatric disorders: compendium 2006. Am Psychiatric Pub, Washington
58.
go back to reference Birchwood M, Fiorillo A (2000) The critical period for early intervention. Psychiatric Rehabil Skills 4:182–198CrossRef Birchwood M, Fiorillo A (2000) The critical period for early intervention. Psychiatric Rehabil Skills 4:182–198CrossRef
59.
60.
go back to reference Barnes TR, Leeson VC, Mutsatsa SH et al (2008) Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. Br J Psychiatry 193:203–209PubMedCrossRefPubMedCentral Barnes TR, Leeson VC, Mutsatsa SH et al (2008) Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. Br J Psychiatry 193:203–209PubMedCrossRefPubMedCentral
61.
go back to reference Perkins DO, Gu H, Boteva K et al (2005) Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry 162:1785–1804PubMedCrossRef Perkins DO, Gu H, Boteva K et al (2005) Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry 162:1785–1804PubMedCrossRef
62.
go back to reference Harrigan SM, McGorry P, Krstev H (2003) Does treatment delay in first-episode psychosis really matter? Psychol Med 33:97–110PubMedCrossRef Harrigan SM, McGorry P, Krstev H (2003) Does treatment delay in first-episode psychosis really matter? Psychol Med 33:97–110PubMedCrossRef
63.
go back to reference Penttilä M, Jääskeläinen E, Hirvonen N et al (2014) Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 205:88–94PubMedCrossRef Penttilä M, Jääskeläinen E, Hirvonen N et al (2014) Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 205:88–94PubMedCrossRef
64.
go back to reference Addington J, Leriger E, Addington D (2003) Symptom outcome 1 year after admission to an early psychosis program. Can J Psychiatry 48:204–207PubMed Addington J, Leriger E, Addington D (2003) Symptom outcome 1 year after admission to an early psychosis program. Can J Psychiatry 48:204–207PubMed
65.
go back to reference Lieberman JA, Phillips M, Gu H et al (2003) Atypical and conventional antipsychotic drugs in treatment-naive first-episode schizophrenia: a 52-week randomized trial of clozapine vs chlorpromazine. Neuropsychopharmacology. doi:10.1038/sj.npp.1300157 Lieberman JA, Phillips M, Gu H et al (2003) Atypical and conventional antipsychotic drugs in treatment-naive first-episode schizophrenia: a 52-week randomized trial of clozapine vs chlorpromazine. Neuropsychopharmacology. doi:10.​1038/​sj.​npp.​1300157
66.
go back to reference Coldham E, Addington J, Addington D (2002) Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand 106:286–290PubMedCrossRef Coldham E, Addington J, Addington D (2002) Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand 106:286–290PubMedCrossRef
67.
go back to reference Schennach-Wolff R, Jäger M, Seemüller F et al (2009) Attitude towards adherence in patients with schizophrenia at discharge. J Psychiatr Res 43:1294–1301PubMedCrossRef Schennach-Wolff R, Jäger M, Seemüller F et al (2009) Attitude towards adherence in patients with schizophrenia at discharge. J Psychiatr Res 43:1294–1301PubMedCrossRef
68.
go back to reference Robinson D, Woerner MG, Alvir JMJ et al (1999) Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 56:241–247PubMedCrossRef Robinson D, Woerner MG, Alvir JMJ et al (1999) Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 56:241–247PubMedCrossRef
69.
go back to reference Watt DC, Katz K, Shepherd M (1983) The natural history of schizophrenia: a 5-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psychol Med 13:663–670PubMedCrossRef Watt DC, Katz K, Shepherd M (1983) The natural history of schizophrenia: a 5-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psychol Med 13:663–670PubMedCrossRef
70.
go back to reference Melle I, Johannesen J, Friis S et al (2006) Early detection of the first episode of schizophrenia and suicidal behavior. Am J Psychiatry 163:800–804PubMedCrossRef Melle I, Johannesen J, Friis S et al (2006) Early detection of the first episode of schizophrenia and suicidal behavior. Am J Psychiatry 163:800–804PubMedCrossRef
71.
go back to reference Birchwood M (2003) Pathways to emotional dysfunction in first-episode psychosis. Br J Psychiatry 182:373–375PubMedCrossRef Birchwood M (2003) Pathways to emotional dysfunction in first-episode psychosis. Br J Psychiatry 182:373–375PubMedCrossRef
72.
go back to reference Wisdom JP, Manuel JI, Drake RE (2011) Substance use disorder among people with first-episode psychosis: a systematic review of course and treatment. Psychiatric Serv 62:1007–1012CrossRef Wisdom JP, Manuel JI, Drake RE (2011) Substance use disorder among people with first-episode psychosis: a systematic review of course and treatment. Psychiatric Serv 62:1007–1012CrossRef
73.
go back to reference Bechdolf PDA, Pohlmann B, Güttgemanns J et al (2012) Motivationsbehandlung für Patienten mit der Doppeldiagnose Psychose und Sucht. Der Nervenarzt 83:888–896PubMedCrossRef Bechdolf PDA, Pohlmann B, Güttgemanns J et al (2012) Motivationsbehandlung für Patienten mit der Doppeldiagnose Psychose und Sucht. Der Nervenarzt 83:888–896PubMedCrossRef
74.
go back to reference Elkins K, Hinton M, Edwards J (2004) Cannabis and psychosis: a psychological intervention. In: Gleeson JFM, McGorry PD (eds) Psychological interventions in early psychosis. Wiley, Chichester, p 137–156. ISBN: 0470020636, 9780470020630 Elkins K, Hinton M, Edwards J (2004) Cannabis and psychosis: a psychological intervention. In: Gleeson JFM, McGorry PD (eds) Psychological interventions in early psychosis. Wiley, Chichester, p 137–156. ISBN: 0470020636, 9780470020630
75.
go back to reference Meister K, Burlon M, Rietschel L et al (2010) Psychose und Sucht bei Jugendlichen und Jungerwachsenen BR Teil 1: Prävalenz und Erklärungsmodelle. Fortschritte der Neurologie Psychiatrie 78:81–89PubMedCrossRef Meister K, Burlon M, Rietschel L et al (2010) Psychose und Sucht bei Jugendlichen und Jungerwachsenen BR Teil 1: Prävalenz und Erklärungsmodelle. Fortschritte der Neurologie Psychiatrie 78:81–89PubMedCrossRef
76.
go back to reference Álvarez-Jiménez M, Parker AG, Hetrick SE et al (2011) Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis. Schizophr Bull 37:619–630PubMedCrossRefPubMedCentral Álvarez-Jiménez M, Parker AG, Hetrick SE et al (2011) Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis. Schizophr Bull 37:619–630PubMedCrossRefPubMedCentral
77.
go back to reference Bird V, Premkumar P, Kendall T et al (2010) Early intervention services, cognitive–behavioural therapy and family intervention in early psychosis: systematic review. Br J Psychiatry 197:350–356PubMedCrossRefPubMedCentral Bird V, Premkumar P, Kendall T et al (2010) Early intervention services, cognitive–behavioural therapy and family intervention in early psychosis: systematic review. Br J Psychiatry 197:350–356PubMedCrossRefPubMedCentral
79.
go back to reference Nuechterlein KH, Dawson ME (1984) A heuristic vulnerability/stress model of schizophrenic episodes. Schizophr Bull 10:300–312PubMedCrossRef Nuechterlein KH, Dawson ME (1984) A heuristic vulnerability/stress model of schizophrenic episodes. Schizophr Bull 10:300–312PubMedCrossRef
80.
go back to reference Larsen TK, Bechdolf A, Birchwood M (2003) The concept of schizophrenia and phase-specific treatment: cognitive-behavioral treatment in pre-psychosis and in nonresponders. J Am Acad Psychoanal Dyn Psychiatry 31:209–228PubMedCrossRef Larsen TK, Bechdolf A, Birchwood M (2003) The concept of schizophrenia and phase-specific treatment: cognitive-behavioral treatment in pre-psychosis and in nonresponders. J Am Acad Psychoanal Dyn Psychiatry 31:209–228PubMedCrossRef
81.
go back to reference Garety PA, Kuipers E, Fowler D et al (2001) A cognitive model of the positive symptoms of psychosis. Psychol Med 31:189–195PubMedCrossRef Garety PA, Kuipers E, Fowler D et al (2001) A cognitive model of the positive symptoms of psychosis. Psychol Med 31:189–195PubMedCrossRef
82.
go back to reference Cantor-Graae E, Selten JP (2005) Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 162:12–24PubMedCrossRef Cantor-Graae E, Selten JP (2005) Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 162:12–24PubMedCrossRef
83.
go back to reference Matheson SL, Shepherd AM, Pinchbeck RM et al (2013) Childhood adversity in schizophrenia: a systematic meta-analysis. Psychol Med 43:225–238PubMedCrossRef Matheson SL, Shepherd AM, Pinchbeck RM et al (2013) Childhood adversity in schizophrenia: a systematic meta-analysis. Psychol Med 43:225–238PubMedCrossRef
86.
go back to reference Fine C, Gardner M, Craigie J et al (2007) Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cogn Neuropsychiatr 12:46–77CrossRef Fine C, Gardner M, Craigie J et al (2007) Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cogn Neuropsychiatr 12:46–77CrossRef
87.
go back to reference Morris EMJ, Johns LC, Oliver JE (2013) Acceptance and commitment therapy and mindfulness for psychosis. Wiley, LondonCrossRef Morris EMJ, Johns LC, Oliver JE (2013) Acceptance and commitment therapy and mindfulness for psychosis. Wiley, LondonCrossRef
88.
go back to reference Kingdon DG, Turkington D (2005) Cognitive therapy of schizophrenia [electronic resource]. Guilford Publications, Incorporated, New York Kingdon DG, Turkington D (2005) Cognitive therapy of schizophrenia [electronic resource]. Guilford Publications, Incorporated, New York
89.
go back to reference Lieberman JA, Fenton WS (2000) Delayed detection of psychosis: causes, consequences, and effect on public health. Am J Psychiatry 157:1727–1730PubMedCrossRef Lieberman JA, Fenton WS (2000) Delayed detection of psychosis: causes, consequences, and effect on public health. Am J Psychiatry 157:1727–1730PubMedCrossRef
90.
go back to reference Henry L (2002) Cognitively oriented psychotherapy for first episode psychosis (COPE): a practitioner’s manual: early psychosis prevention and intervention centre. ISBN: 192071801X Henry L (2002) Cognitively oriented psychotherapy for first episode psychosis (COPE): a practitioner’s manual: early psychosis prevention and intervention centre. ISBN: 192071801X
91.
go back to reference Herrmann-Doig T, Maude D, Edwards J (2002) Systematic Treatment of Persistent Psychosis (STOPP): a psychological approach to facilitating recovery in young people with first-episode psychosis. Taylor & Francis, LondonCrossRef Herrmann-Doig T, Maude D, Edwards J (2002) Systematic Treatment of Persistent Psychosis (STOPP): a psychological approach to facilitating recovery in young people with first-episode psychosis. Taylor & Francis, LondonCrossRef
92.
go back to reference French P, Morrison AP (2004) Early detection and cognitive therapy for people at high risk of developing psychosis: a treatment approach. Wiley, LondonCrossRef French P, Morrison AP (2004) Early detection and cognitive therapy for people at high risk of developing psychosis: a treatment approach. Wiley, LondonCrossRef
93.
go back to reference Müller H, Bechdolf A (2013) Ist eine Behandlung mit Antipsychotika gerechtfertigt? InFo Neurologie & Psychiatrie 15:38–42CrossRef Müller H, Bechdolf A (2013) Ist eine Behandlung mit Antipsychotika gerechtfertigt? InFo Neurologie & Psychiatrie 15:38–42CrossRef
94.
go back to reference McGlashan TH, Levy ST, Carpenter WT Jr (1975) Integration and sealing over: clinically distinct recovery styles from schizophrenia. Arch Gen Psychiatry 32:1269PubMedCrossRef McGlashan TH, Levy ST, Carpenter WT Jr (1975) Integration and sealing over: clinically distinct recovery styles from schizophrenia. Arch Gen Psychiatry 32:1269PubMedCrossRef
95.
go back to reference Gleeson JFM, McGorry PD (2004) Psychological interventions in early psychosis: a treatment handbook. Wiley, London Gleeson JFM, McGorry PD (2004) Psychological interventions in early psychosis: a treatment handbook. Wiley, London
96.
go back to reference Taylor SE (1983) Adjustment to threatening events: a theory of cognitive adaptation. Am Psychol 38:1161CrossRef Taylor SE (1983) Adjustment to threatening events: a theory of cognitive adaptation. Am Psychol 38:1161CrossRef
98.
go back to reference Häfner HBA, Klosterkötter J, Maurer K (2012) Psychosen - Früherkennung und Frühintervention. Der Praxisleitfaden. Schattauer, Stuttgart Häfner HBA, Klosterkötter J, Maurer K (2012) Psychosen - Früherkennung und Frühintervention. Der Praxisleitfaden. Schattauer, Stuttgart
100.
go back to reference Birchwood M, Connor C, Lester H et al (2013) Reducing duration of untreated psychosis: care pathways to early intervention in psychosis services. Br J Psychiatry 203:58–64PubMedCrossRef Birchwood M, Connor C, Lester H et al (2013) Reducing duration of untreated psychosis: care pathways to early intervention in psychosis services. Br J Psychiatry 203:58–64PubMedCrossRef
101.
go back to reference NICE. National Institute for Health and Clinical Excellence Schizophrenia (2009) Core interventions in the treatment and management of schizophrenia in primary and secondary care (update). National Institute for Health and Clinical Excellence, London NICE. National Institute for Health and Clinical Excellence Schizophrenia (2009) Core interventions in the treatment and management of schizophrenia in primary and secondary care (update). National Institute for Health and Clinical Excellence, London
102.
go back to reference Phillips LJ, Cotton S, Mihalopoulos C et al (2009) Cost implications of specific and non-specific treatment for young persons at ultra high risk of developing a first episode of psychosis. Early Interv Psychiatry 3:28–34PubMedCrossRef Phillips LJ, Cotton S, Mihalopoulos C et al (2009) Cost implications of specific and non-specific treatment for young persons at ultra high risk of developing a first episode of psychosis. Early Interv Psychiatry 3:28–34PubMedCrossRef
103.
go back to reference Valmaggia LR, McCrone P, Knapp M et al (2009) Economic impact of early intervention in people at high risk of psychosis. Psychol Med 39:1617–1626PubMedCrossRef Valmaggia LR, McCrone P, Knapp M et al (2009) Economic impact of early intervention in people at high risk of psychosis. Psychol Med 39:1617–1626PubMedCrossRef
104.
go back to reference Bechdolf A, Muller H, Stutzer H et al (2011) Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis. Schizophr Bull 37(Suppl 2):S111–S121PubMedCrossRefPubMedCentral Bechdolf A, Muller H, Stutzer H et al (2011) Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis. Schizophr Bull 37(Suppl 2):S111–S121PubMedCrossRefPubMedCentral
105.
go back to reference Häfner H, Bechdolf A, Klosterkötter J et al. Psychosen - Früherkennung und Frühintervention: Der Praxisleitfaden: Schattauer; 2012 Häfner H, Bechdolf A, Klosterkötter J et al. Psychosen - Früherkennung und Frühintervention: Der Praxisleitfaden: Schattauer; 2012
Metadata
Title
Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis
Authors
Hendrik Müller
Sonja Laier
Andreas Bechdolf
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue Special Issue 1/2014
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-014-0538-0

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