Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 5/2014

01-08-2014 | Original Paper

Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters

Authors: Raffaella Calati, Ina Giegling, Martina Balestri, Niki Antypa, Marion Friedl, Bettina Konte, Annette M. Hartmann, Alessandro Serretti, Dan Rujescu

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 5/2014

Login to get access

Abstract

Although a genetic contribution to the complex aetiology of suicidal behaviour has been suggested since many years, the attempt to identify specific genes related to suicide has led to contrasting results. In a post-mortem study on suicide, we previously detected several differentially expressed genes which, however, have not been subsequently associated with suicidal behaviour, or only nominally. Therefore, personality traits may represent good intermediate endophenotypes. Our primary aim was to investigate the potential modulation of several single-nucleotide polymorphisms (SNPs) of the same previously investigated genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) on personality traits, as measured with the Temperament and Character Inventory (TCI), in a German sample composed of 287 healthy subjects (males: 123, 42.9 %; mean age: 45.2 ± 14.9 years) and in 111 psychiatric patients who attempted suicide (males: 43, 38.6 %; mean age: 39.2 ± 13.6 years). Multivariate analysis of covariance was used to test possible influence of single SNPs on TCI scores. Genotypic, allelic and haplotypic analyses have been performed. Controlling for sex, age and educational level, genotypic analyses showed a modulation of EFEMP1 rs960993 and rs2903838 polymorphisms on both harm avoidance and self-directedness in healthy subjects. Interestingly, we could replicate these associations in haploblocks within controls (p < 0.0001) and in the independent sample of suicide attempters for harm avoidance (p < 0.00001), a phenotype highly associated with suicidal behaviour. This study suggests that EFEMP1 SNPs, never investigated in association with suicidal behaviour and related personality, could be involved in its modulation in healthy subjects as well as in suicide attempters.
Appendix
Available only for authorised users
Literature
1.
WHO (2000) Health systems: improving performance. World Health Organization, Geneva
2.
Levi F et al (2003) Trends in mortality from suicide, 1965–99. Acta Psychiatr Scand 108(5):341–349PubMedCrossRef
3.
4.
Roy A (1993) Genetic and biologic risk factors for suicide in depressive disorders. Psychiatr Q 64(4):345–358PubMedCrossRef
5.
Statham DJ et al (1998) Suicidal behaviour: an epidemiological and genetic study. Psychol Med 28(4):839–855PubMedCrossRef
6.
Brent DA, Mann JJ (2005) Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 133C(1):13–24PubMedCrossRef
7.
Roy A, Segal NL, Sarchiapone M (1995) Attempted suicide among living co-twins of twin suicide victims. Am J Psychiatry 152(7):1075–1076PubMed
8.
McGuffin P, Marusic A, Farmer A (2001) What can psychiatric genetics offer suicidology? Crisis 22(2):61–65PubMedCrossRef
9.
Rujescu D et al (2007) Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system? Arch Suicide Res 11(1):17–40PubMedCrossRef
10.
Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33(10):1193–1197PubMedCrossRef
11.
Mann JJ, Malone KM (1997) Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 41(2):162–171PubMedCrossRef
12.
Lidberg L et al (2000) Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. Acta Psychiatr Scand 101(5):395–402PubMedCrossRef
13.
Rujescu D, Giegling I (2010) The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin. Eur Psychiatry 25(5):272–274PubMedCrossRef
14.
Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160(4):636–645PubMedCrossRef
15.
16.
Brezo J, Paris J, Turecki G (2006) Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review. Acta Psychiatr Scand 113(3):180–206PubMedCrossRef
17.
18.
19.
Rujescu D, Giegling I (2012) Intermediate phenotypes in suicidal behavior focus on personality. In: Dwivedi Y (ed) The neurobiological basis of suicide, Chap 18. CRC Press, Boca Raton, FL
20.
Rothenhausler HB, Stepan A, Kapfhammer HP (2006) Soluble interleukin 2 receptor levels, temperament and character in formerly depressed suicide attempters compared with normal controls. Suicide Life Threat Behav 36(4):455–466PubMedCrossRef
21.
Becerra B et al (2005) Temperament and character profile of persons with suicide attempt. Actas Esp Psiquiatr 33(2):117–122PubMed
22.
Favaro A et al (2008) Self-injurious behavior and attempted suicide in purging bulimia nervosa: associations with psychiatric comorbidity. J Affect Disord 105(1–3):285–289PubMedCrossRef
23.
Evren C, Evren B (2006) The relationship of suicide attempt history with childhood abuse and neglect, alexithymia and temperament and character dimensions of personality in substance dependents. Nord J Psychiatry 60(4):263–269PubMedCrossRef
24.
Thalmeier A et al (2008) Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims. Int J Neuropsychopharmacol 11(2):217–228PubMedCrossRef
25.
Harris MA et al. (2004) The gene ontology (GO) database and informatics resource. Nucleic Acids Res 32(Database issue):D258–D261
26.
Pierce DW (1981) The predictive validation of a suicide intent scale: a five year follow-up. Br J Psychiatry 139:391–396PubMedCrossRef
27.
First MB et al (1990) Structured clinical interview for DSM-IV axis II personality disorders (SCID-II). Biometrics Research Department, New York State Psychiatric Institute, New York
28.
First MB et al (1995) Structured clinical interview for DSM-IV axis I disorders—patient edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute, New York
29.
Calati R et al (2008) Temperament and character of suicide attempters. J Psychiatr Res 42(11):938–945PubMedCrossRef
30.
Giegling I et al (2006) Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. J Affect Disord 96(1–2):75–81PubMedCrossRef
31.
Serretti A et al (2007) 5-HT2A SNPs and the temperament and character inventory. Prog Neuropsychopharmacol Biol Psychiatry 31(6):1275–1281PubMedCrossRef
32.
Serretti A et al (2009) Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls. J Psychiatr Res 43(5):519–525PubMedCrossRef
33.
Giegling I et al (2009) Personality and attempted suicide. Analysis of anger, aggression and impulsivity. J Psychiatr Res 43(16):1262–1271PubMedCrossRef
34.
Cloninger CR et al (1994) The temperament and character inventory (TCI): a guide to its development and use. Center for Psychobiology of Personality Washington University, St. Louis, Missouri
35.
Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50(12):975–990PubMedCrossRef
36.
Brandstrom S, Richter J, Nylander PO (2003) Further development of the Temperament and Character Inventory. Psychol Rep 93(3 Pt 2):995–1002PubMedCrossRef
37.
Rujescu D et al (2003) A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 54(1):34–39PubMedCrossRef
38.
Barrett JC et al (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263–265PubMedCrossRef
39.
Gabriel SB et al (2002) The structure of haplotype blocks in the human genome. Science 296(5576):2225–2229PubMedCrossRef
40.
41.
Faul F (2007) G*Power. Universitat Kiel, Germany
42.
Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Hillsdale, NJ, pp 8–14
43.
Lecka-Czernik B, Lumpkin CK Jr, Goldstein S (1995) An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis. Mol Cell Biol 15(1):120–128PubMedCentralPubMed
44.
45.
Marijnissen G et al (2002) The temperament and character inventory in major depression. J Affect Disord 70(2):219–223PubMedCrossRef
46.
Farmer A et al (2003) A sib-pair study of the Temperament and Character Inventory scales in major depression. Arch Gen Psychiatry 60(5):490–496PubMedCrossRef
47.
Celikel FC et al (2009) Cloninger’s temperament and character dimensions of personality in patients with major depressive disorder. Compr Psychiatry 50(6):556–561PubMedCrossRef
48.
Jylha P et al (2011) Differences in temperament and character dimensions in patients with bipolar I or II or major depressive disorder and general population subjects. Psychol Med 41(8):1579–1591PubMedCrossRef
49.
Ekinci O, Albayrak Y, Ekinci AE (2012) Temperament and character in euthymic major depressive disorder patients: the effect of previous suicide attempts and psychotic mood episodes. Psychiatry Investig 9(2):119–126PubMedCentralPubMedCrossRef
50.
Fassino S et al (2009) Personality trait interactions in parents of patients with borderline personality disorder: a controlled study using the Temperament and Character Inventory. Psychiatry Res 165(1–2):128–136PubMedCrossRef
51.
Svrakic DM et al (1993) Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Arch Gen Psychiatry 50(12):991–999PubMedCrossRef
52.
Sarisoy G et al. (2012) Temperament and character traits in patients with bipolar disorder and associations with attempted suicide. Compr Psychiatry 53(8):1096–1102PubMedCrossRef
53.
Conrad R et al (2009) Temperament and character personality profile in relation to suicidal ideation and suicide attempts in major depressed patients. Psychiatry Res 170(2–3):212–217PubMedCrossRef
54.
Csorba J et al (2010) Novelty seeking: difference between suicidal and non-suicidal Hungarian adolescent outpatients suffering from depression. J Affect Disord 120(1–3):217–220PubMedCrossRef
55.
Albayrak Y, Ekinci O, Caykoylu A (2012) Temperament and character personality profile in relation to suicide attempts in patients with schizophrenia. Compr Psychiatry 53(8):1130–1136PubMedCrossRef
56.
Sayin A et al (2007) Relation of temperament and character properties with clinical presentation of bipolar disorder. Compr Psychiatry 48(5):446–451PubMedCrossRef
57.
Aukst Margetic B et al. (2012) Current suicidality and previous suicidal attempts in patients with schizophrenia are associated with different dimensions of temperament and character. Psychiatry Res 200(2–3):120–125PubMedCrossRef
58.
Carballo E, Lai WS, Blackshear PJ (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281(5379):1001–1005PubMedCrossRef
59.
Al-Souhibani N et al (2010) The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes. Oncogene 29(29):4205–4215PubMedCentralPubMedCrossRef
60.
De Fruyt F, Van De Wiele L, Van Heeringen C (2000) Cloninger’s psychobiological model of temperament and character and the five-factor model of personality. Pers Individ Differ 29:441–452CrossRef
61.
62.
Bouhuys AL et al (2004) Potential psychosocial mechanisms linking depression to immune function in elderly subjects. Psychiatry Res 127(3):237–245PubMedCrossRef
63.
Capuron L et al (2011) Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med 41(7):1517–1528PubMedCrossRef
64.
Roy B et al (2010) Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA). Psychosom Med 72(2):134–140PubMedCentralPubMedCrossRef
65.
Jonassaint CR et al (2010) Personality and inflammation: the protective effect of openness to experience. Ethn Dis 20(1):11–14PubMedCentralPubMed
66.
67.
Brandstrom S, Richter J, Przybeck T (2001) Distributions by age and sex of the dimensions of temperament and character inventory in a cross-cultural perspective among Sweden, Germany, and the USA. Psychol Rep 89(3):747–758PubMedCrossRef
68.
Cavalli Sforza L, History The (1994) Geography of Human Genes. Princeton University Press, Princeton, NJ
69.
Strakowski SM et al (1992) Possible affective-state dependence of the Tridimensional Personality Questionnaire in first-episode psychosis. Psychiatry Res 41(3):215–226PubMedCrossRef
70.
Richter J, Eisemann M, Richter G (2000) Temperament and character during the course of unipolar depression among inpatients. Eur Arch Psychiatry Clin Neurosci 250(1):40–47PubMedCrossRef
71.
Ohi K et al. (2012) Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Res 198(1):7–11PubMedCrossRef
72.
Jetha MK, Goldberg JO, Schmidt LA (2012) Temperament and its relation to social functioning in schizophrenia. Int J Soc Psychiatry 59(3):254–263PubMedCrossRef
73.
Neuner T et al (2008) Predicting inpatient suicides and suicide attempts by using clinical routine data? Gen Hosp Psychiatry 30(4):324–330PubMedCrossRef
Metadata
Title
Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters
Authors
Raffaella Calati
Ina Giegling
Martina Balestri
Niki Antypa
Marion Friedl
Bettina Konte
Annette M. Hartmann
Alessandro Serretti
Dan Rujescu
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 5/2014
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-013-0469-1

Other articles of this Issue 5/2014

European Archives of Psychiatry and Clinical Neuroscience 5/2014 Go to the issue

Original Paper

Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults

Original Paper

High social support buffers the effects of 5-HTTLPR genotypes within social anxiety disorder

Original Paper

Fluid intelligence and empathy in association with personality disorder trait-scores: exploring the link

Original Paper

SPOCK3, a risk gene for adult ADHD and personality disorders

Original Paper

Memories of attachment hamper EEG cortical connectivity in dissociative patients

Short Communication

Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders