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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 5/2013

01-08-2013 | Original Paper

Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T

Authors: Gagan Joshi, Joseph Biederman, Janet Wozniak, Rachel L. Goldin, Dave Crowley, Stephannie Furtak, Scott E. Lukas, Atilla Gönenç

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 5/2013

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Abstract

The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 ± 1.8; age range: 12–17 years) with intact intellectual capacity (mean IQ: 108 ± 14.26; IQ range: 85–127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.
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Metadata
Title
Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T
Authors
Gagan Joshi
Joseph Biederman
Janet Wozniak
Rachel L. Goldin
Dave Crowley
Stephannie Furtak
Scott E. Lukas
Atilla Gönenç
Publication date
01-08-2013
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 5/2013
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-012-0369-9

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