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European Archives of Psychiatry and Clinical Neuroscience

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01-04-2009 | ORIGINAL PAPER

Dysbindin gene (DTNBP1) and schizophrenia in Korean population

Authors: Chi-Un Pae, Laura Mandelli, Diana De Ronchi, Jung-Jin Kim, MD, Tae-Youn Jun, MD, Ashwin A. Patkar, Alessandro Serretti

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2009

Abstract

Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today. This study tried to replicate the genetic association of DTNBP1 with schizophrenia in a large Korean sample, as well as analyzing the association of DTNBP1 with clinical variables. Nine hundred and eight (908) patients with schizophrenia and 601 controls were investigated. The high-throughput genotyping method using pyrosequencer (Biotage AB, Sweden) was used for genotyping 4 SNPs (rs3213207, rs1011313, rs760761, and rs2619522). Haplotype analyses revealed a significant association with schizophrenia (P < 0.0001) with the haplotypes A-C-C-C and A-C-T-A having an eminent protective effect toward schizophrenia. The major contribution to the difference in the haplotype distribution between patients and the controls was the rs760761 (C/T) and rs2619522 (A/C) haplotypes (P < 0.0001). No association of DTNBP1 with other clinical variables was found. In conclusion, the present study suggests a possible protective effect of rare DTNBP1 variants in schizophrenia, although subsequent studies in different ethnic groups are warranted.

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Title: Dysbindin gene (DTNBP1) and schizophrenia in Korean population
Authors: Chi-Un Pae
Laura Mandelli
Diana De Ronchi
Jung-Jin Kim, MD
Tae-Youn Jun, MD
Ashwin A. Patkar
Alessandro Serretti
Publication date: 01-04-2009
Publisher: Steinkopff-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2009
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-008-0830-y

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Dysbindin gene (DTNBP1) and schizophrenia in Korean population

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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