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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 1/2007

01-02-2007 | ORIGINAL PAPER

Insight and regional brain volumes in schizophrenia

Authors: Débora Pastore Bassitt, Mario Rodrigues Louzã Neto, Cláudio Campi de Castro, Geraldo F. Busatto

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 1/2007

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Abstract

We have investigated the relationship between insight impairment and regional brain volumes (gray and white matter) in schizophrenia using voxel-based morphometry (VBM). Fifty patients with schizophrenia were evaluated using the Scale for Unawareness of Mental Disorders. Magnetic resonance images were acquired, segmented and spatially normalized using optimized VBM routines. No significant inverse correlations were detected between insight impairment and gray or white matter volumes in the prefrontal region (where significant findings had been predicted a priori), or in any other brain areas. Our results do not support previous hypotheses suggesting a relationship between frontal lobe atrophy and impaired insight in patients with schizophrenia.
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Metadata
Title
Insight and regional brain volumes in schizophrenia
Authors
Débora Pastore Bassitt
Mario Rodrigues Louzã Neto
Cláudio Campi de Castro
Geraldo F. Busatto
Publication date
01-02-2007
Publisher
Steinkopff-Verlag
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 1/2007
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-006-0685-z

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