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European Archives of Oto-Rhino-Laryngology

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01-05-2021 | Endoscopy | Laryngology

Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

Authors: Emilien Chabrillac, Gaël Espinasse, Benoît Lepage, Emmanuelle Uro-Coste, Agnès Dupret-Bories, Guillaume De Bonnecaze, Sébastien Vergez

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2021

Abstract

Purpose

The aim of this study was to assess the performance of Narrow Band Imaging (NBI) added to White Light (WL) in the delineation of laryngopharyngeal superficial cancer spread during office-based transnasal flexible endoscopy.

Methods

This bi-centric prospective study was conducted between October 2014 and December 2017. We included consecutive patients with laryngopharyngeal malignant tumors. Transnasal flexible endoscopy was performed by two endoscopists who were blinded to each other's assessments and who examined each patient independently. The first endoscopist only performed a WL examination, while the second endoscopist carried out both WL and NBI. The extent of tumor involvement was reported based on predefined anatomical sub-units. Biopsies in NBI + /WL− sub-units were subsequently performed during panendoscopy.

Results

Eighty-four patients were included in the study. A total of 72 NBI + /WL− sub-units were sampled in 38 patients, and 37 of the biopsies were positive (51.4%): 16 for invasive carcinoma, 17 for high-grade dysplasia/carcinoma in situ and 4 for low-grade dysplasia. Ultimately, 26.2% of patients had at least one positive biopsy in an NBI + /WL− sub-unit and, therefore, a better tumor delineation. The clinical T stage was upgraded in 4.8% of cases examined.

Conclusion

Adding NBI to WL imaging during transnasal flexible endoscopy in patients presenting with laryngopharyngeal pre-malignant or malignant lesions improves the delineation of superficial cancer spread, thereby leading to better adapted treatments.

Clinicaltrials.gov registration number: NCT02035735.

East JE, Tan EK, Bergman JJ, Saunders BP, Tekkis PP. Meta-analysis: narrow band imaging for lesion characterization in the colon, oesophagus, duodenal ampulla and lung. Aliment Pharmacol Ther. 2008;28(7):854–67.

Mari A, Abufaraj M, Gust KM, Shariat SF (2018) Novel endoscopic visualization techniques for bladder cancer detection: a review of the contemporary literature. Curr Opin Urol 28(2):214–218CrossRef

Zhou H, Zhang J, Guo L, Nie J, Zhu C, Ma X (2018) The value of narrow band imaging in diagnosis of head and neck cancer: a meta-analysis. Sci Rep. 8(1):515CrossRef

Ni X-G, He S, Xu Z-G, Gao L, Lu N, Yuan Z et al (2011) Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 125(3):288–296CrossRef

Arens C, Piazza C, Andrea M, Dikkers FG, Tjon Pian Gi REA, Voigt-Zimmermann S et al (2016) Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Oto Rhino Laryngol. 273(5):1207–1214CrossRef

Slaughter DP, Southwick HW, Smejkal W (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6(5):963–968CrossRef

Tabor MP, Brakenhoff RH, van Houten VMM, Kummer JA, Snel MHJ, Snijders PJF et al (2001) Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res 7(6):1523–1532PubMed

Cosway B, Drinnan M, Paleri V (2016) Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: a systematic review. Head Neck 38(Suppl 1):E2358-2367CrossRef

Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM (2010) The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol 35(5):364–372CrossRef

10.

Kraft M, Fostiropoulos K, Gürtler N, Arnoux A, Davaris N, Arens C (2016) Value of narrow band imaging in the early diagnosis of laryngeal cancer. Head Neck 38(1):15–20CrossRef

11.

Bertino G, Cacciola S, Fernandes WB, Fernandes CM, Occhini A, Tinelli C et al (2015) Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification. Head Neck 37(2):215–222CrossRef

12.

Piazza C, Cocco D, De Benedetto L, Bon FD, Nicolai P, Peretti G (2010) Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy. Eur Arch Oto-Rhino-Laryngol 267(9):1423–1428CrossRef

13.

Nonaka S, Saito Y (2008) Endoscopic diagnosis of pharyngeal carcinoma by NBI. Endoscopy 40(4):347–351CrossRef

14.

Šifrer R, Rijken JA, Leemans CR, Eerenstein SEJ, van Weert S, Hendrickx J-J et al (2018) Evaluation of vascular features of vocal cords proposed by the European Laryngological Society. Eur Arch Oto-Rhino-Laryngol 275(1):147–151CrossRef

15.

Piazza C, Dessouky O, Peretti G, Cocco D, De Benedetto L, Nicolai P (2008) Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. Review of the literature. Acta Otorhinolaryngol Ital Organo Uff Della Soc Ital Otorinolaringol E Chir Cerv-facc. 28(2):49–54

16.

Mehlum CS, Rosenberg T, Dyrvig A-K, Groentved AM, Kjaergaard T, Godballe C (2018) Can the Ni classification of vessels predict neoplasia? A systematic review and meta-analysis. Laryngoscope 128(1):168–176CrossRef

17.

Matsuba H, Katada C, Masaki T, Nakayama M, Okamoto T, Hanaoka N et al (2011) Diagnosis of the extent of advanced oropharyngeal and hypopharyngeal cancers by narrow band imaging with magnifying endoscopy. Laryngoscope 121(4):753–759CrossRef

18.

Muto M, Minashi K, Yano T, Saito Y, Oda I, Nonaka S et al (2010) Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol 28(9):1566–1572CrossRef

19.

Garofolo S, Piazza C, Del Bon F, Mangili S, Guastini L, Mora F et al (2015) Intraoperative narrow band imaging better delineates superficial resection margins during transoral laser microsurgery for early glottic cancer. Ann Otol Rhinol Laryngol 124(4):294–298CrossRef

20.

Fiz I, Mazzola F, Fiz F, Marchi F, Filauro M, Paderno A et al (2017) Impact of close and positive margins in transoral laser microsurgery for Tis-T2 glottic cancer. Front Oncol 7:245CrossRef

21.

Piersiala K, Klimza H, Jackowska J, Majewska A, Wierzbicka M (2018) Narrow band imaging in transoral laser microsurgery (TLM) in moderately advanced (T2, T3) glottic cancer. Otolaryngol Pol Pol Otolaryngol 72(5):17–23CrossRef

22.

Campo F, D’Aguanno V, Greco A, Ralli M, de Vincentiis M (2019) The prognostic value of adding narrow-band imaging in transoral laser microsurgery for early glottic cancer: a review. Lasers Surg Med. 52:301–306CrossRef

23.

Plaat BEC, Zwakenberg MA, van Zwol JG, Wedman J, van der Laan BFAM, Halmos GB et al (2017) Narrow-band imaging in transoral laser surgery for early glottic cancer in relation to clinical outcome. Head Neck 39(7):1343–1348CrossRef

24.

Zwakenberg MA, Dikkers FG, Wedman J, van der Laan BFAM, Halmos GB, Plaat BEC (2019) Detection of high-grade dysplasia, carcinoma in situ and squamous cell carcinoma in the upper aerodigestive tract: Recommendations for optimal use and interpretation of narrow-band imaging. Clin Otolaryngol 44(1):39–46CrossRef

25.

Zabrodsky M, Lukes P, Lukesova E, Boucek J, Plzak J (2014) The role of narrow band imaging in the detection of recurrent laryngeal and hypopharyngeal cancer after curative radiotherapy. BioMed Res Int 2014:175398CrossRef

26.

Valls-Mateus M, Nogués-Sabaté A, Blanch JL, Bernal-Sprekelsen M, Avilés-Jurado FX, Vilaseca I (2018) Narrow band imaging for head and neck malignancies: lessons learned from mistakes. Head Neck 40(6):1164–1173CrossRef

27.

Ni X-G, Zhu J-Q, Zhang Q-Q, Zhang B-G, Wang G-Q (2019) Diagnosis of vocal cord leukoplakia: the role of a novel narrow band imaging endoscopic classification. Laryngoscope 129(2):429–434CrossRef

28.

Piazza C, Del Bon F, Paderno A, Grazioli P, Perotti P, Barbieri D et al (2016) The diagnostic value of narrow band imaging in different oral and oropharyngeal subsites. Eur Arch Oto-Rhino-Laryngol 273(10):3347–3353CrossRef

29.

Vilaseca I, Valls-Mateus M, Nogués A, Lehrer E, López-Chacón M, Avilés-Jurado FX et al (2017) Usefulness of office examination with narrow band imaging for the diagnosis of head and neck squamous cell carcinoma and follow-up of premalignant lesions. Head Neck 39(9):1854–1863CrossRef

30.

Nogués-Sabaté A, Aviles-Jurado FX, Ruiz-Sevilla L, Lehrer E, Santamaría-Gadea A, Valls-Mateus M et al (2018) Intra and interobserver agreement of narrow band imaging for the detection of head and neck tumors. Eur Arch Oto-Rhino-Laryngol 275(9):2349–2354CrossRef

Title: Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study
Authors: Emilien Chabrillac
Gaël Espinasse
Benoît Lepage
Emmanuelle Uro-Coste
Agnès Dupret-Bories
Guillaume De Bonnecaze
Sébastien Vergez
Publication date: 01-05-2021
Publisher: Springer Berlin Heidelberg
Keywords: Endoscopy
Laryngeal Cancer
Laryngeal Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06499-2

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Springer Medicine

Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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