Top

European Archives of Oto-Rhino-Laryngology

Published in:

Open Access 01-05-2021 | Rhinosinusitis | Rhinology

Differences in men and women suffering from CRSwNP and AERD in quality of life

Authors: Tina J. Bartosik, David T. Liu, Nicholas J. Campion, Sergio Villazala-Merino, Stefan Janik, Valerie Dahm, Christian A. Mueller, Erich Vyskocil, Victoria Stanek, Tamara Quint, Christine Bangert, Julia Eckl-Dorna, Sven Schneider

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2021

Abstract

Purpose

While the overall impact of chronic rhinosinusitis (CRS) on patients’ health is diverse, many affected individuals have a substantially impaired quality of life (QoL). The aim of this study was to evaluate the impact of sex-associated differences specifically in the subgroups of CRS with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) by assessing QoL parameters in women and men separately.

Methods

In a retrospective single-center study, 59 patients with CRSwNP (39 males and 20 females) and 46 patients with AERD (18 males and 28 females) were included. Patient-reported outcome measures (PROM) evaluating QoL via the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) as well as the total polyp score (TPS) were analysed.

Results

There was no significant difference in TPS (p = 0.5550) and total SNOT-20 GAV scores (p = 0.0726) between male or female patients with CRSwNP or AERD. Furthermore, no significant sex differences were found within disease groups regarding the subcategories of the SNOT-20 GAV items.

Conclusion

Thus, quality of life is severely impaired in patients suffering from various forms of CRS regardless of their sex.

Regitz-Zagrosek V (2012) Sex and gender differences in health. EMBO Rep 13:596–603. https://doi.org/10.1038/embor.2012.87CrossRefPubMedPubMedCentral

Bartz D, Chitnis T, Kaiser UB et al (2020) Clinical advances in sex- and gender-informed medicine to improve the health of all: a review. JAMA Intern Med 180:574–583. https://doi.org/10.1001/jamainternmed.2019.7194CrossRefPubMed

DeConde AS, Soler ZM (2016) Chronic rhinosinusitis: epidemiology and burden of disease. Am J Rhinol Allergy 30:134–139. https://doi.org/10.2500/ajra.2016.30.4297CrossRefPubMed

Hastan D, Fokkens WJ, Bachert C et al (2011) Chronic rhinosinusitis in Europe—an underestimated disease. A GA2LEN study. Allergy 66:1216–1223. https://doi.org/10.1111/j.1398-9995.2011.02646.xCrossRefPubMed

de Loos DD, Lourijsen ES, Wildeman MAM et al (2019) Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology. J Allergy ClinImmunol 143:1207–1214. https://doi.org/10.1016/j.jaci.2018.12.986CrossRef

Fokkens WJ, Lund VJ, Hopkins C et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58:1–464. https://doi.org/10.4193/Rhin20.600CrossRefPubMed

Bachert C, Akdis CA (2016) Phenotypes and emerging endotypes of chronic rhinosinusitis. J Allergy ClinImmunolPract 4:621–628. https://doi.org/10.1016/j.jaip.2016.05.004CrossRef

Rajan JP, Wineinger NE, Stevenson DD, White AA (2015) Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature. J Allergy ClinImmunol 135:676-681.e1. https://doi.org/10.1016/j.jaci.2014.08.020CrossRef

Schneider S, Campion NJ, Villazala-Merino S et al (2020) Associations between the quality of life and nasal polyp size in patients suffering from chronic rhinosinusitis without nasal polyps, with nasal polyps or aspirin-exacerbated respiratory disease. J Clin Med 9:925. https://doi.org/10.3390/jcm9040925CrossRefPubMedCentral

10.

Baumann I, Plinkert PK, Maddalena HD (2008) Entwicklungeinerbewertungsskalafür den sino-nasal outcome test-20 german adapted version (SNOT-20 GAV). HNO 56:784–788. https://doi.org/10.1007/s00106-007-1606-9CrossRefPubMed

11.

Morley A, d., Sharp H r. (2006) A review of sinonasal outcome scoring systems—which is best? ClinOtolaryngol 31:103–109. https://doi.org/10.1111/j.1749-4486.2006.01155.xCrossRef

12.

Jurlin L, Gregurić T, Baudoin T et al (2019) Cluster analysis of chronic rhinosinusitis suggests gender-based differences. ORL J OtorhinolaryngolRelat Spec 81(1):1–9. https://doi.org/10.1159/000492966CrossRef

13.

Lal D, Golisch KB, Elwell ZA et al (2016) Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol 6:896–905. https://doi.org/10.1002/alr.21773CrossRefPubMed

14.

Busaba NY, Sin H-J, Salman SD (2008) Impact of gender on clinical presentation of chronic rhinosinusitis with and without polyposis. J LaryngolOtol 122:1180–1184. https://doi.org/10.1017/S0022215107001302CrossRef

15.

Mendolia-Loffredo S, Laud PW, Sparapani R et al (2006) Sex differences in outcomes of sinus surgery. Laryngoscope 116:1199–1203. https://doi.org/10.1097/01.mlg.0000224575.12945.90CrossRefPubMed

16.

Kowalski ML, Agache I, Bavbek S et al (2019) Diagnosis and management of NSAID-exacerbated respiratory disease (N-ERD)—a EAACI position paper. Allergy 74:28–39. https://doi.org/10.1111/all.13599CrossRefPubMed

17.

Meltzer EO, Hamilos DL, Hadley JA et al (2006) Rhinosinusitis: Developing guidance for clinical trials. J Allergy ClinImmunol 118:S17–S61. https://doi.org/10.1016/j.jaci.2006.09.005CrossRef

18.

Gevaert P, Calus L, Zele TV et al (2013) Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy ClinImmunol 131:110-116.e1. https://doi.org/10.1016/j.jaci.2012.07.047CrossRef

19.

Piccirillo JF, Merritt MG, Richards ML (2002) Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (Snot-20). Otolaryngol Neck Surg 126:41–47. https://doi.org/10.1067/mhn.2002.121022CrossRef

20.

Baumann I, Blumenstock G, DeMaddalena H et al (2007) LebensqualitätbeiPatienten mit chronischer Rhinosinusitis. HNO 55:42–47. https://doi.org/10.1007/s00106-005-1347-6CrossRefPubMed

21.

Gemmati D, Varani K, Bramanti B et al (2020) “Bridging the Gap” everything that could have been avoided if we had applied gender medicine, pharmacogenetics and personalized medicine in the gender-omics and sex-omics era. Int J Mol Sci 21:296. https://doi.org/10.3390/ijms21010296CrossRef

22.

Baetta R, Pontremoli M, Martinez Fernandez A et al (2018) Proteomics in cardiovascular diseases: unveiling sex and gender differences in the era of precision medicine. J Proteomics 173:62–76. https://doi.org/10.1016/j.jprot.2017.11.012CrossRefPubMed

23.

Ulrich BC, Guibert N (2018) Immunotherapy efficacy and gender: discovery in precision medicine. Transl Lung Cancer Res 7:S211–S213. https://doi.org/10.21037/tlcr.2018.08.05CrossRefPubMedPubMedCentral

24.

Golan Y, Gavriel H, Lazarovich T, Eviatar E (2017) Gender differences in the bacteriology of rhinosinusitis. Eur Arch Otorhinolaryngol 274:2803–2807. https://doi.org/10.1007/s00405-017-4560-5CrossRefPubMed

25.

Jang DW, Comer BT, Lachanas VA, Kountakis SE (2014) Aspirin sensitivity does not compromise quality-of-life outcomes in patients with samter’s triad. Laryngoscope 124:34–37. https://doi.org/10.1002/lary.24220CrossRefPubMed

26.

Katotomichelakis M, Riga M, Davris S et al (2009) Allergic rhinitis and aspirin-exacerbated respiratory disease as predictors of the olfactory outcome after endoscopic sinus surgery. Am J Rhinol Allergy 23:348–353. https://doi.org/10.2500/ajra.2009.23.3325CrossRefPubMed

27.

Kennedy JL, Stoner AN, Borish L (2016) Aspirin-exacerbated respiratory disease: prevalence, diagnosis, treatment, and considerations for the future. Am J Rhinol Allergy 30:407–413. https://doi.org/10.2500/ajra.2016.30.4370CrossRefPubMedPubMedCentral

28.

Bartley EJ, Fillingim RB (2013) Sex differences in pain: a brief review of clinical and experimental findings. BJA Br J Anaesth 111:52–58. https://doi.org/10.1093/bja/aet127CrossRefPubMed

29.

Macintyre S, Hunt K, Sweeting H (1996) Gender differences in health: are things really as simple as they seem? Soc Sci Med 42:617–624. https://doi.org/10.1016/0277-9536(95)00335-5CrossRefPubMed

30.

Ference EH, Tan BK, Hulse KE et al (2015) Commentary on gender differences in prevalence, treatment, and quality of life of patients with chronic rhinosinusitis. Allergy Rhinol 6:e82–e88. https://doi.org/10.2500/ar.2015.6.0120CrossRef

31.

Baumann I, Blumenstock G (2005) Impact of gender on general health-related quality of life in patients with chronic sinusitis. Am J Rhinol 19:282–287CrossRefPubMed

32.

Baumann I, Blumenstock G, Zalaman IM et al (2007) Impact of gender, age, and comorbidities on quality of life in patients with chronic rhinosinusitis. Rhinology 45:268–272PubMed

33.

Ren L, Zhang N, Zhang L, Bachert C (2019) Biologics for the treatment of chronic rhinosinusitis with nasal polyps—state of the art. World Allergy Organ J 12:100050. https://doi.org/10.1016/j.waojou.2019.100050CrossRefPubMedPubMedCentral

Title: Differences in men and women suffering from CRSwNP and AERD in quality of life
Authors: Tina J. Bartosik
David T. Liu
Nicholas J. Campion
Sergio Villazala-Merino
Stefan Janik
Valerie Dahm
Christian A. Mueller
Erich Vyskocil
Victoria Stanek
Tamara Quint
Christine Bangert
Julia Eckl-Dorna
Sven Schneider
Publication date: 01-05-2021
Publisher: Springer Berlin Heidelberg
Keyword: Rhinosinusitis
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06418-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Differences in men and women suffering from CRSwNP and AERD in quality of life

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 5/2021

Assessment of Stroop Color Word Interference Test-TBAG form performance in subjects with tinnitus

Quality-of-life evaluation for patients submitted to nasal endoscopic surgery for resection of pituitary tumours

Three-dimensional modeling and automatic analysis of the human nasal cavity and paranasal sinuses using the computational fluid dynamics method

COVID-19 and ENT surgery: a brief review of essential precautions and triage

Facial taping as biofeedback to improve the outcomes of physical rehab in Bell’s palsy: preliminary results of a randomized case–control study

Tumor volume as a prognostic factor of locally advanced laryngeal cancer