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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 4/2021

01-04-2021 | Head and Neck

Recurrence-free survival and prognostic factors of odontogenic keratocyst: a single-center retrospective cohort

Authors: Glória Maria de França, Luíza Borba Antunes da Silva, Rodrigo Porpino Mafra, Weslay Rodrigues da Silva, Kênio Costa de Lima, Hébel Cavalcanti Galvão

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2021

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Abstract

Purpose

The aim of the present study was to evaluate the 5-year recurrence-free survival and prognostic factors of odontogenic keratocyst (OKC) from a single-center retrospective cohort in the northeastern region of Brazil.

Methods

Forty cases of OKC comprised the study population. In the cohort analyzed, 18 (45%) cases were recurrent OKCs and 22 (55%) were non-recurrent OKCs. Recurrence-free survival was defined as the period from the release of the histopathological report to the occurrence of relapse or last visit to the service.

Results

Comparison of the clinicopathological variables between primary and recurrent OKC lesions revealed no differences in the frequency of epithelial thickness, presence of satellite cysts and cystic spaces, presence of an inflammatory infiltrate, locularity, and lesion borders. The frequency of symptoms was practically the same even after recurrence. Satellite cysts were more frequent in the group of recurrent lesions (n = 9, p = 0.002) and the presence of an inflammatory infiltrate was also significantly associated with recurrent lesions (n = 15, p = 0.006). Previous decompression or marsupialization was associated with recurrence of the lesion (p = 0.010).

Conclusions

In conclusion, the most significant prognostic factors were previous decompression or marsupialization, as well as, morphological parameters associated with the recurrence cases were the presence of an inflammatory infiltrate and satellites cysts. The risk of recurrence is low but continues due to the particularities of epithelial proliferation in OKC.
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Metadata
Title
Recurrence-free survival and prognostic factors of odontogenic keratocyst: a single-center retrospective cohort
Authors
Glória Maria de França
Luíza Borba Antunes da Silva
Rodrigo Porpino Mafra
Weslay Rodrigues da Silva
Kênio Costa de Lima
Hébel Cavalcanti Galvão
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 4/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-020-06229-8

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