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European Archives of Oto-Rhino-Laryngology

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01-02-2019 | Head & Neck

Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas

Authors: Akshat Malik, Burhanuddin N. Qayyumi, Manish Mair, Hitesh Singhavi, Yash Mathur, Deepa Nair, Sarbani Ghosh-Laskar, Jai Prakash Agrawal, Kumar Prabash, Pankaj Chaturvedi

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2019

Abstract

Background

This study was undertaken to assess the effects of neo-adjuvant chemotherapy (NACT) on patients with head and neck squamous cell carcinoma (HNSCC) having advanced unresectable cervical nodal metastasis.

Methodology

A retrospective cohort study was conducted to assess the response of unresectable nodes to NACT in a pragmatic manner. Patients were grouped according to the response noted and the treatment offered after chemotherapy. The median survival amongst the patients in these groups was compared.

Results

The study included 51 patients. Oral cavity was the commonest site (67.2%). Favourable nodal response was seen in 64.7% of the patients. Up to 87.9% of the nodal responders were amenable to curative intent therapy. The overall survival of patients undergoing surgery, definitive chemoradiotherapy, palliative chemotherapy and palliative radiotherapy was 24, 13, 10 and 9 months, respectively.

Conclusion

NACT may be utilized in HNSCC with advanced inoperable nodal disease to make them amenable to definitive therapy.

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Title: Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas
Authors: Akshat Malik
Burhanuddin N. Qayyumi
Manish Mair
Hitesh Singhavi
Yash Mathur
Deepa Nair
Sarbani Ghosh-Laskar
Jai Prakash Agrawal
Kumar Prabash
Pankaj Chaturvedi
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5253-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas

Abstract

Background

Methodology

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methodology

Results

Conclusion

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