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European Archives of Oto-Rhino-Laryngology

Published in:

01-08-2018 | Head and Neck

Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

Authors: Süleyman Oyan, Arzu Tatlıpınar, Beste M. Atasoy, Pembegül Güneş, Dilek Özbeyli, Serhan Keskin, Ayse Dağlı Değerli

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2018

Abstract

Objective

The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradiation on laryngeal mucosa in rats.

Study design

Animal study.

Setting

Experimental animal laboratory, tertiary referral center.

Subject and method

Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation. Ionizing radiation was administered in a single fraction of a 20 Gy to the larynx. Laryngeal tissue samples were taken at the 4th day of irradiation and all specimens underwent histopathological examination.

Results

Edema and vascular dilation in lamina propria were higher in the reflux and irradiation, and irradiation groups than control group. Inflammation was higher in the reflux and irradiation group than the control group. Inflammation in squamous epithelium was higher in the reflux and irradiation and irradiation groups compared to the control group. Inflammation in the squamous epithelium of the irradiation group was higher than the reflux and irradiation group. In the respiratory tract epithelium, inflammation was higher in the reflux and irradiation group; additionally, a significant loss of cilia was present in the reflux and irradiation and irradiation groups while pseudostratification was higher in the reflux and irradiation group.

Conclusion

Ionizing radiation-induced inflammation may increase on previously inflammated area due to gastroesophageal reflux. Therefore, it may be helpful to investigate and treat the reflux in laryngeal cancer patients that will receive ionizing radiation.

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Title: Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study
Authors: Süleyman Oyan
Arzu Tatlıpınar
Beste M. Atasoy
Pembegül Güneş
Dilek Özbeyli
Serhan Keskin
Ayse Dağlı Değerli
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 8/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5010-8

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Early effects of irradiation on laryngeal mucosa in a gastroesophageal reflux model: an experimental study

Abstract

Objective

Study design

Setting

Subject and method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Study design

Setting

Subject and method

Results

Conclusion

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