Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 5/2018

01-05-2018 | Otology

Intratympanic steroid use for idiopathic sudden sensorineural hearing loss: current otolaryngology practice in Germany and Austria

Authors: L. Sutton, V. Schartinger, C. Url, J. Schmutzhard, D. Lechner, C. Kavasogullari, J. S. Sandhu, A. Shaida, R. Laszig, J. Loehler, S. Plontke, H. Riechelmann, M. Lechner

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2018

Login to get access

Abstract

Aims

The frequency of the use of intratympanic steroids (ITS) as a treatment for idiopathic sudden sensorineural hearing loss (ISSNHL) in Europe is still unknown and remains a contentious issue amongst otolaryngologists. We undertook a survey of otolaryngologists in Germany and Austria to establish if there is any professional consensus with which to form a protocol for its use.

Methods

A survey of 21 questions was distributed electronically to otolaryngologists in Germany and Austria and data on demographics, indications for intratympanic treatment, procedure, follow-up, and outcomes were analysed.

Results

We received 908 responses. 49.1% of otolaryngologists used ITS for ISSNHL. Of those otolaryngologists who use ITS, 73.7% do not use it as primary treatment. 20.6% use ITS in conjunction with oral steroids for primary treatment and only 5.8% use ITS as monotherapy for primary treatment. 90.5% use ITS as salvage therapy. 81.1% do not consider the use of ITS after 2 weeks from the onset of symptoms. 8.3% used a tympanostomy tube and while the most commonly used steroid was dexamethasone at a concentration of 4 mg/ml (61%), a wide variety or other steroids and concentrations were used.

Conclusions

This survey illustrates wide variation of current practice of intratympanic corticosteroid injection for ISSHL in Germany and Austria. In the absence of high-level evidence, knowing what current practice is allows clinicians to assess what they do against what their colleagues are doing, and if they do something very different, make them question their practice. Moreover, the obtained data will help to direct future clinical trials with the aim to compare the outcomes of more commonly used protocols.
Appendix
Available only for authorised users
Literature
2.
go back to reference Plontke SK, Bauer M, Meisner C (2007) Comparison of pure-tone audiometry analysis in sudden hearing loss studies: lack of agreement for different outcome measures. Otol Neurotol 28(6):753–763CrossRefPubMed Plontke SK, Bauer M, Meisner C (2007) Comparison of pure-tone audiometry analysis in sudden hearing loss studies: lack of agreement for different outcome measures. Otol Neurotol 28(6):753–763CrossRefPubMed
3.
go back to reference Byl FM Jr (1984) Sudden hearing loss: eight years’ experience and suggested prognostic table. Laryngoscope 94:647–661CrossRefPubMed Byl FM Jr (1984) Sudden hearing loss: eight years’ experience and suggested prognostic table. Laryngoscope 94:647–661CrossRefPubMed
4.
go back to reference Rauch SD (2008) Clinical practice. Idiopathic sudden sensorineural hearing loss. New Engl J Med 359(8):833–840CrossRefPubMed Rauch SD (2008) Clinical practice. Idiopathic sudden sensorineural hearing loss. New Engl J Med 359(8):833–840CrossRefPubMed
5.
go back to reference Koltsidopoulos P, Biba A, Sismanis A, Tzonoun A, Seggas I (2013) Intratympanic and systemic steroids for sudden hearing loss. Otol Neurotol 34:771–776CrossRefPubMed Koltsidopoulos P, Biba A, Sismanis A, Tzonoun A, Seggas I (2013) Intratympanic and systemic steroids for sudden hearing loss. Otol Neurotol 34:771–776CrossRefPubMed
6.
go back to reference Klemm E, Deutscher A, Mösges R (2009) A present investigation of the epidemiology in idiopathic sudden sensorineural hearing loss. Laryngorhinootologie 88(8):524–527CrossRefPubMed Klemm E, Deutscher A, Mösges R (2009) A present investigation of the epidemiology in idiopathic sudden sensorineural hearing loss. Laryngorhinootologie 88(8):524–527CrossRefPubMed
7.
go back to reference Olzowy B, Osterkorn D, Suckfüll M (2005) The incidence of sudden hearing loss is greater than previously assumed. MMW Fortschr Med 147(14):37–38PubMed Olzowy B, Osterkorn D, Suckfüll M (2005) The incidence of sudden hearing loss is greater than previously assumed. MMW Fortschr Med 147(14):37–38PubMed
8.
go back to reference Wilson WR, Byl FM, Laird N (1980) The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol 106:772–776CrossRefPubMed Wilson WR, Byl FM, Laird N (1980) The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol 106:772–776CrossRefPubMed
9.
go back to reference Meltser I, Canlon B (2011) Protecting the auditory system with glucocorticoids. Hear Res 281(1–2):47–55CrossRefPubMed Meltser I, Canlon B (2011) Protecting the auditory system with glucocorticoids. Hear Res 281(1–2):47–55CrossRefPubMed
10.
go back to reference Trune DR, Canlon B (2012) Corticosteroid therapy for hearing and balance disorders. Anat Rec (Hoboken) 295(11):1928–1943CrossRef Trune DR, Canlon B (2012) Corticosteroid therapy for hearing and balance disorders. Anat Rec (Hoboken) 295(11):1928–1943CrossRef
11.
go back to reference Moskowitz D, Lee KJ, Smith HW (1984) Steroid use in idiopathic sudden sensorineural hearing loss. Laryngoscope 94:664–666CrossRefPubMed Moskowitz D, Lee KJ, Smith HW (1984) Steroid use in idiopathic sudden sensorineural hearing loss. Laryngoscope 94:664–666CrossRefPubMed
13.
go back to reference Chandrasekhar SS, Rubinstein RY, Kwartler JA (2000) Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg 122:521–528PubMed Chandrasekhar SS, Rubinstein RY, Kwartler JA (2000) Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg 122:521–528PubMed
14.
go back to reference Parnes LS, Sun AH, Freeman DJ (1999) Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 109:1–17CrossRefPubMed Parnes LS, Sun AH, Freeman DJ (1999) Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 109:1–17CrossRefPubMed
15.
go back to reference Rauch SD, Halpin CF, Antonelli PJ, Babu S, Carey JP, Gantz BJ et al (2011) Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA 305(20):2071–2079CrossRefPubMed Rauch SD, Halpin CF, Antonelli PJ, Babu S, Carey JP, Gantz BJ et al (2011) Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA 305(20):2071–2079CrossRefPubMed
16.
go back to reference Crane RA, Camilon M, Nguyen S, Meyer TA (2015) Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope 125(1):209–217CrossRefPubMed Crane RA, Camilon M, Nguyen S, Meyer TA (2015) Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope 125(1):209–217CrossRefPubMed
17.
go back to reference Liebau A, Pogorzelski O, Salt AN, Plontke SK (2017) Hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of drug delivery protocols. Otol Neurotol 38(1):19–30CrossRefPubMedPubMedCentral Liebau A, Pogorzelski O, Salt AN, Plontke SK (2017) Hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of drug delivery protocols. Otol Neurotol 38(1):19–30CrossRefPubMedPubMedCentral
18.
go back to reference Garavello W, Galluzzi F, Gaini RM, Zanetti D (2012) Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials. Otol Neurotol 33(5):724–729CrossRefPubMed Garavello W, Galluzzi F, Gaini RM, Zanetti D (2012) Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials. Otol Neurotol 33(5):724–729CrossRefPubMed
19.
go back to reference Li H, Feng G, Wang H, Feng Y (2015) Intratympanic steroid therapy as a salvage treatment for sudden sensorineural hearing loss after failure of conventional therapy: a meta-analysis of randomized, controlled trials. Clin Ther 37(1):178–187CrossRefPubMed Li H, Feng G, Wang H, Feng Y (2015) Intratympanic steroid therapy as a salvage treatment for sudden sensorineural hearing loss after failure of conventional therapy: a meta-analysis of randomized, controlled trials. Clin Ther 37(1):178–187CrossRefPubMed
20.
go back to reference Ng JH, Ho RC, Cheong CS, Ng A, Yuen HW, Ngo RY (2015) Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis. Eur Arch Otorhinolaryngol 272(10):2777–2782CrossRefPubMed Ng JH, Ho RC, Cheong CS, Ng A, Yuen HW, Ngo RY (2015) Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis. Eur Arch Otorhinolaryngol 272(10):2777–2782CrossRefPubMed
21.
go back to reference Gao Y, Liu D (2016) Combined intratympanic and systemic use of steroids for idiopathic sudden sensorineural hearing loss: a meta-analysis. Eur Arch Otorhinolaryngol 273(11):3699–3711CrossRefPubMed Gao Y, Liu D (2016) Combined intratympanic and systemic use of steroids for idiopathic sudden sensorineural hearing loss: a meta-analysis. Eur Arch Otorhinolaryngol 273(11):3699–3711CrossRefPubMed
22.
go back to reference Battaglia A, Lualhati A, Lin H, Burchette R, Cueva R (2014) A prospective, multi-centered study of the treatment of idiopathic sudden sensorineural hearing loss with combination therapy versus high-dose prednisone alone: a 139 patient follow-up. Otol Neurotol 35(6):1091–1098CrossRefPubMed Battaglia A, Lualhati A, Lin H, Burchette R, Cueva R (2014) A prospective, multi-centered study of the treatment of idiopathic sudden sensorineural hearing loss with combination therapy versus high-dose prednisone alone: a 139 patient follow-up. Otol Neurotol 35(6):1091–1098CrossRefPubMed
23.
go back to reference Günel C, Başal Y, Toka A, Eryılmaz A, Kurt Ömürlü I (2015) Efficacy of low-dose intratympanic dexamethasone for sudden hearing loss. Auris Nasus Larynx 42(4):284–287CrossRefPubMed Günel C, Başal Y, Toka A, Eryılmaz A, Kurt Ömürlü I (2015) Efficacy of low-dose intratympanic dexamethasone for sudden hearing loss. Auris Nasus Larynx 42(4):284–287CrossRefPubMed
24.
go back to reference Siegel LG (1975) The treatment of idiopathic sudden sensorineural hearing loss. Otolarynol Clin North Am 8(2):467–473 Siegel LG (1975) The treatment of idiopathic sudden sensorineural hearing loss. Otolarynol Clin North Am 8(2):467–473
26.
go back to reference Belhassen S, Saliba I (2014) Intratympanic steroid injection as a salvage treatment for sudden sensorineural hearing loss. J Laryngol Otol 128(12):1044–1049CrossRefPubMed Belhassen S, Saliba I (2014) Intratympanic steroid injection as a salvage treatment for sudden sensorineural hearing loss. J Laryngol Otol 128(12):1044–1049CrossRefPubMed
27.
go back to reference Liebau A, Pogorzelski P, Salt AN, Zenner HP, Plontke SK (2017) Dependence of hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Otol Neurotol 38(1):19–30CrossRefPubMedPubMedCentral Liebau A, Pogorzelski P, Salt AN, Zenner HP, Plontke SK (2017) Dependence of hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Otol Neurotol 38(1):19–30CrossRefPubMedPubMedCentral
28.
go back to reference Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT (2004) Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope 114(7):1184–1189CrossRefPubMed Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT (2004) Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope 114(7):1184–1189CrossRefPubMed
29.
go back to reference Lee JB, Choi SJ, Park K, Park HY, Choo OS, Choung YH (2011) The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 268:833–839CrossRefPubMed Lee JB, Choi SJ, Park K, Park HY, Choo OS, Choung YH (2011) The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 268:833–839CrossRefPubMed
30.
go back to reference Wu HP, Chou YF, Yu SH, Wang CP, Hsu CJ, Chen PR (2011) Intratympanic steroid injections as a salvage treatment for sudden sensorineural hearing loss: a randomized, double-blind, placebo-controlled study. Otol Neurotol 32(5):774–779CrossRefPubMed Wu HP, Chou YF, Yu SH, Wang CP, Hsu CJ, Chen PR (2011) Intratympanic steroid injections as a salvage treatment for sudden sensorineural hearing loss: a randomized, double-blind, placebo-controlled study. Otol Neurotol 32(5):774–779CrossRefPubMed
31.
go back to reference Xenellis J, Papadimitriou N, Nikolopoulos T, Maragoudakis P, Segas J, Tzagaroulakis A et al (2006) Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg 134(6):940–945CrossRefPubMed Xenellis J, Papadimitriou N, Nikolopoulos T, Maragoudakis P, Segas J, Tzagaroulakis A et al (2006) Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg 134(6):940–945CrossRefPubMed
32.
go back to reference Zhao D, Tong B, Wang Q, Hellstrom S, Duan M (2016) A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss: A meta-analysis. J Otol 11(1):18–23CrossRef Zhao D, Tong B, Wang Q, Hellstrom S, Duan M (2016) A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss: A meta-analysis. J Otol 11(1):18–23CrossRef
33.
go back to reference Kosyakov S, Atanesyan A, Gunenkov A, Ashkhatunyan E, Kurlova A (2011) Intratympanic steroids for sudden sensorineural hearing loss. J Int Adv Otol 7(3):323–332 Kosyakov S, Atanesyan A, Gunenkov A, Ashkhatunyan E, Kurlova A (2011) Intratympanic steroids for sudden sensorineural hearing loss. J Int Adv Otol 7(3):323–332
34.
go back to reference Bird PA, Begg EJ, Zhang M, Keast AT, Murray DP, Balkany TJ (2007) Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 28(8):1124–1130CrossRefPubMed Bird PA, Begg EJ, Zhang M, Keast AT, Murray DP, Balkany TJ (2007) Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 28(8):1124–1130CrossRefPubMed
35.
go back to reference Bird PA, Murray DP, Zhang M, Begg EJ (2011) Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otol Neurotol 32(6):933–936CrossRefPubMed Bird PA, Murray DP, Zhang M, Begg EJ (2011) Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otol Neurotol 32(6):933–936CrossRefPubMed
36.
go back to reference Salt AN, Hartsock JJ, Gill RM, Piu F, Plontke SK (2012) Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal. J Assoc Res Otolaryngol 13(6):771–783CrossRefPubMedPubMedCentral Salt AN, Hartsock JJ, Gill RM, Piu F, Plontke SK (2012) Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal. J Assoc Res Otolaryngol 13(6):771–783CrossRefPubMedPubMedCentral
38.
go back to reference Plontke SK, Glien A, Rahne T, Mäder K, Salt AN (2014) Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol 35(7):1168–1171PubMedPubMedCentral Plontke SK, Glien A, Rahne T, Mäder K, Salt AN (2014) Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol 35(7):1168–1171PubMedPubMedCentral
Metadata
Title
Intratympanic steroid use for idiopathic sudden sensorineural hearing loss: current otolaryngology practice in Germany and Austria
Authors
L. Sutton
V. Schartinger
C. Url
J. Schmutzhard
D. Lechner
C. Kavasogullari
J. S. Sandhu
A. Shaida
R. Laszig
J. Loehler
S. Plontke
H. Riechelmann
M. Lechner
Publication date
01-05-2018
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 5/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-018-4958-8

Other articles of this Issue 5/2018

European Archives of Oto-Rhino-Laryngology 5/2018 Go to the issue